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The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and its enantiomers.

2017/27/B/NZ7/01873

Keywords:

chronic unpredictable mild stress ketamine antidepressant drugs mice mGlu2 receptor mGlu5 receptor

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Pałucha-Poniewiera 

Number of co-investigators in the project: 8

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 106 660 PLN

Project start date (Y-m-d): 2018-08-08

Project end date (Y-m-d): 2023-08-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. The Antidepressant-like Activity and Cognitive Enhancing Effects of the Combined Administration of (R)-Ketamine and LY341495 in the CUMS Model of Depression in Mice Are Related to the Modulation of Excitatory Synaptic Transmission and LTP in the PFC.
    Authors:
    Agnieszka Pałucha-Poniewiera, Bartosz Bobula, Anna Rafao-Ulińska
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16(2), strony: 288), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16020288 - link to the publication
  2. The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice
    Authors:
    Agnieszka Pałucha-Poniewiera *, Karolina Podkowa, Anna Rafało-Ulińska, Piotr Brański, Grzegorz Burnat
    Academic press:
    Behavioural Pharmacology (rok: 2020, tom: 31, strony: 574-582), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/FBP.0000000000000564 - link to the publication
  3. The role of mGlu2/3 receptor antagonists in the enhancement of the antidepressant-like effect of ketamine.
    Authors:
    Agnieszka Pałucha-Poniewiera
    Academic press:
    Pharmacology Biochemistry and Behavior (rok: 2022, tom: 220, strony: 173454), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2022.173454 - link to the publication
  4. The group II mGlu receptor antagonist LY341495 induces a rapid antidepressant-like effect and enhances the effect of ketamine in the chronic unpredictable mild stress model of depression in C57BL/6J mice.
    Authors:
    Agnieszka Pałucha-Poniewiera, Karolina Podkowa, Anna Rafało-Ulińska
    Academic press:
    Prog Neuropsychopharmacol Biol Psychiatry (rok: 2021, tom: 109, strony: brak), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2020.110239 - link to the publication
  5. Combined administration of (R)-Ketamine and the mGlu2/3 receptor antagonist LY341495 induces rapid and sustained effects in the CUMS model of depression via a TrkB/BDNF-dependent mechanism.
    Authors:
    Anna Rafało-Ulińska, Piotr Brański, Agnieszka Pałucha-Poniewiera
    Academic press:
    Pharmaceuticals (rok: 2022, tom: 15, strony: 125), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph15020125 - link to the publication
  6. The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice
    Authors:
    Anna Rafało-Ulińska, Agnieszka Pałucha-Poniewiera
    Academic press:
    Behavioural Brain Research (rok: 2022, tom: 418, strony: 113633), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2021.113633 - link to the publication

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