The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and its enantiomers.
2017/27/B/NZ7/01873
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Farmakologii PAN
Voivodeship: małopolskie
Principal investigator (from the host institution)
dr hab. Agnieszka Pałucha-Poniewiera
Number of co-investigators in the project: 8
Call
OPUS 14 – announced on 2017-09-15
- Amount awarded
- 1 106 660 PLN
- Project start date
- 2018-08-08
- Project end date
- 2023-08-07
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (6)
-
The role of mGlu2/3 receptor antagonists in the enhancement of the antidepressant-like effect of ketamine.
- Authors:
- Agnieszka Pałucha-Poniewiera
- Academic press:
- Pharmacology Biochemistry and Behavior (year: 2022, volume: 220, pages: 173454), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pbb.2022.173454 – link to the publication
-
Combined administration of (R)-Ketamine and the mGlu2/3 receptor antagonist LY341495 induces rapid and sustained effects in the CUMS model of depression via a TrkB/BDNF-dependent mechanism.
- Authors:
- Anna Rafało-Ulińska, Piotr Brański, Agnieszka Pałucha-Poniewiera
- Academic press:
- Pharmaceuticals (year: 2022, volume: 15, pages: 125), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ph15020125 – link to the publication
-
The Antidepressant-like Activity and Cognitive Enhancing Effects of the Combined Administration of (R)-Ketamine and LY341495 in the CUMS Model of Depression in Mice Are Related to the Modulation of Excitatory Synaptic Transmission and LTP in the PFC.
- Authors:
- Agnieszka Pałucha-Poniewiera, Bartosz Bobula, Anna Rafao-Ulińska
- Academic press:
- Pharmaceuticals (year: 2023, volume: 16(2), pages: 288), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ph16020288 – link to the publication
-
The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice
- Authors:
- Anna Rafało-Ulińska, Agnieszka Pałucha-Poniewiera
- Academic press:
- Behavioural Brain Research (year: 2022, volume: 418, pages: 113633), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbr.2021.113633 – link to the publication
-
The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice
- Authors:
- Agnieszka Pałucha-Poniewiera *, Karolina Podkowa, Anna Rafało-Ulińska, Piotr Brański, Grzegorz Burnat
- Academic press:
- Behavioural Pharmacology (year: 2020, volume: 31, pages: 574-582), Publisher: Wolters Kluwer
- Status:
- Published
- DOI:
- 10.1097/FBP.0000000000000564 – link to the publication
-
The group II mGlu receptor antagonist LY341495 induces a rapid antidepressant-like effect and enhances the effect of ketamine in the chronic unpredictable mild stress model of depression in C57BL/6J mice.
- Authors:
- Agnieszka Pałucha-Poniewiera, Karolina Podkowa, Anna Rafało-Ulińska
- Academic press:
- Prog Neuropsychopharmacol Biol Psychiatry (year: 2021, volume: 109, pages: brak), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pnpbp.2020.110239 – link to the publication