Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Selected antidepressants toxicity assessment based on in vitro studies of rat spermatocytes and mouse cell lines.

2014/15/N/NZ7/04097

Keywords:

antidepressants toxicity mejotic division spindle apparatus synaptonemal complex DNA methylation.

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ1_1: Molecular biology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Rzeszowski, Wydział Biotechnologii

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Przemysław Sołek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 149 940 PLN

Project start date (Y-m-d): 2015-07-23

Project end date (Y-m-d): 2019-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Klotho-mediated changes in shelterin complex promote cytotoxic autophagy and apoptosis in amitriptyline-treated hippocampal neuronal cells
    Authors:
    Jennifer Mytych, Przemyslaw Solek, Anna Tabecka-Lonczynska, Marek Koziorowski
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56, strony: 6952-6963), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-019-1575-5 - link to the publication
  2. Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies
    Authors:
    Przemyslaw Solek, Oliwia Koszla, Jennifer Mytych, Joanna Badura, Zaneta Chelminiak, Magdalena Cuprys, Joanna Fraczek, Anna Tabecka-Lonczynska, Marek Koziorowski
    Academic press:
    Apoptosis (rok: 2019, tom: 24, strony: 773-784), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-019-01557-5 - link to the publication
  3. Molecular consequences of depression treatment: a potential mechanism for antidepressants-induced reprotoxic side effects
    Authors:
    Przemyslaw Solek, Jennifer Mytych, Anna Tabecka-Lonczynska, Marek Koziorowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, ), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  4. Toxic effect of antidepressants on male reproductive system cells: evaluation of possible fertility reduction mechanism
    Authors:
    Przemyslaw Solek, Jennifer Mytych, Anna Tabecka-Lonczynska, Magdalena Sowa-Kucma, Marek Koziorowski
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2021, tom: 72, strony: ), Wydawca: Polish Physiological Society
    Status:
    Accepted for publication
    DOI:
    10.26402/jpp.2021.3.xx - link to the publication
  1. OCENA FARMAKOTOKSYCZNYCH WŁAŚCIWOŚCI LEKÓW PRZECIWDEPRESYJNYCH W UKŁADZIE IN VITRO KOMÓREK MYSICH NEURONÓW HIPOKAMPA (HT-22)
    Authors:
    Oliwia Koszla, Joanna Badura, Jennifer Mytych, Marek Koziorowski, Przemyslaw Solek*
    Conference:
    Człowiek – Żywność – Środowisko (rok: 2017, ), Wydawca: Uniwersytet Rzeszowski
    Data:
    konferencja 27-28.04
    Status:
    Published

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