Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Involvement of cyclooxygenase 2 in antidepressant-like effects of metabotropic glutamatergic receptors group I.

2014/13/D/NZ7/00292

Keywords:

Depression mGluR COX-2 second messengers

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Stachowicz 

Number of co-investigators in the project: 6

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 759 250 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2020-02-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kamera cyfrowa.
  2. Klatka do mierzenia interakcji socjalnych u myszy (10 000 PLN)
  3. pH-metr.
  4. Komputer stacjonarny z oprogramowaniem (3 000 PLN)
  5. Aparat do transferu pół-suchego (PIERCE POWER BLOTTER WELCOM PK).
  6. Druciana klatka - element wyposażenia do klatki do mierzenia interakcji socjalnych (4 000 PLN)
  7. Rota Rod dla myszy (26 000 PLN)
  8. Labirynt Barnes dla myszy, zestaw (37 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (12)
  1. Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Marcin Marciniak, Bartosz Bobula, Krzysztof Tokarski
    Academic press:
    Neuroscience Letters (rok: 2021, tom: 741, strony: 135435), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2020.135435 - link to the publication
  2. Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Magdalena Kusek, Tomasz Lenda, Krzysztof Tokarski
    Academic press:
    Brain Research (rok: 2021, tom: 1771, strony: 147660), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review
    Authors:
    Katarzyna Stachowicz
    Academic press:
    Biochemical Pharmacology (rok: 2021, tom: 192, strony: 114729), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bcp.2021.114729 - link to the publication
  4. Upregulation of the mGlu5 receptor and COX-2 protein in the mouse brain after imipramine and NS398, searching for mechanisms of regulation.
    Authors:
    Katarzyna Stachowicz, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Tomasz Lenda, Szymon Rzeźniczek, Magdalena Sowa-Kućma
    Academic press:
    Neurochemistry International (rok: 2021, tom: x, strony: x), Wydawca: ELSEVIER
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. NS398, a cyclooxygenase-2 inhibitor, reverses memory performance disrupted by imipramine in C57Bl/6J mice.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Krzysztof Tokarski
    Academic press:
    Brain Research (rok: 2020, tom: 146741, strony: in press), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.brainres.2020.146741 - link to the publication
  6. Evidence for the interaction of COX-2 with mGluR5 in the regulation of PSD95 and DSCAM proteins, but not mTOR in the mouse hippocampus. The influence of oxidative stress mechanisms.
    Authors:
    Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Magdalena Sowa-Kućma
    Academic press:
    Pharmacology Biochemistry and Behavior (rok: 2021, tom: x, strony: x), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Behavioral consequences of the co-administration of MTEP and the COX-2 inhibitor, NS398 in mice. Part 1
    Authors:
    Katarzyna Stachowicz
    Academic press:
    Behavioural Brain Research (rok: 2019, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  8. The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders. Review
    Authors:
    Stachowicz K.
    Academic press:
    Acta Neurobiol Exp (Wars). (rok: 2018, tom: 78, strony: 210-219), Wydawca: Polish Neuroscience Society/PTBUN/Poland
    Status:
    Published
    DOI:
    PMID: - link to the publication
  1. Changes in serotonin and noradrenaline level in C57Bl/6J mice brain after chronic co-treatment of imipramine with NS398 (COX-2 inhibitor)
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Tomasz Lenda, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Gabriel Nowak, Andrzej Pilc
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudnia 2017
    Status:
    Published
    DOI:
    link to the publication
  2. NS398 (COX-2 inhibitor) potentiates the antidepressant-like effects of MTEP (mGluR5 antagonist): Involvement of 5-HT system
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Tomasz Lenda, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Gabriel Nowak, Andrzej Pilc
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-31 sierpień 2017
    Status:
    Published
    DOI:
    link to the publication
  3. Synergism between mGluR5 and COX-2 in antidepressant-like action is associated with the alterations in NMDA receptors.
    Authors:
    Paulina Misztak, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Szymon Rzeźniczek, Gabriel Nowak, Andrzej Pilc, Katarzyna Stachowicz.
    Conference:
    16th International Forum on Mood and Anxiety Disorders, Rome, Italy (rok: 2016, ), Wydawca: IFMAD
    Data:
    konferencja 8-10.12.2016
    Status:
    Published
  4. The effects of co-administration of mGluR5 antagonist and COX-2 inhibitor on synaptic plasticity in the frontal cortex and hippocampus of mice
    Authors:
    Bobula Bartosz, Hess Grzegorz, Pańczyszyn-Trzewik Patrycja, Misztak Paulina, Nowak Gabriel, Pilc Andrzej, Stachowicz Katarzyna
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  5. Chronic co-administration of mGluR5 antagonist (MTEP) with COX-2 inhibitor (NS398) affects DSCAM expression in pFC and Hp in C57Bl/6J mice
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Szymon Rzeźniczek, Gabriel Nowak, Andrzej Pilc
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  6. Effect of chronic Imipramine with NS-398 (COX-2 inhibitor) injection on the level of BDNF in Hippocampus and Prefrontal Cortex of C57Bl/6J mice
    Authors:
    Paulina Misztak, Patrycja Panczyszyn-Trzewik, Magdalena Sowa-Kućma, Andrzej Pilc, Gabriel Nowak, Katarzyna Stachowicz
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudzień 2017
    Status:
    Published
    DOI:
    link to the publication
  7. Chronic co-treatment of NS398 (COX-2 inhibitor) with MTEP changes strategy of mice in Barnes Maze, through membrane resistance variation.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Magdalena Kusek, Krzysztof Tokarski, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Andrzej Pilc
    Conference:
    ECNP Congress Barcelona, Hiszpania, (rok: 2018, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 6-9 październik 2018
    Status:
    Published
    DOI:
    link to the publication
  8. Effects of acute mGluR7 PAM on changes in short-time plasticity and mGluR7 levels after chronic treatment with mGluR5 antagonist and COX-2 inhibitor
    Authors:
    Bartosz Bobula, , Krzysztof Tokarski, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Andrzej Pilc, Katarzyna Stachowicz
    Conference:
    31st ECNP Congress Barcelona (rok: 2018, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 6-9 październik 2018
    Status:
    Published
    DOI:
    link to the publication
  9. Co-administration of COX-2 inhibitor NS-398 enhances antidepressant effect of mGluR5 antagonist MTEP in mice
    Authors:
    P. Pańczyszyn-Trzewik, P. Misztak, M. Sowa-Kućma, B. Szewczyk, G. Nowak, A. Pilc, K. Stachowicz.
    Conference:
    ECNP Workshop on Neuropsychopharmacology for "Junior Scientists" in Europe, Nice, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 9-12 Marca 2017
    Status:
    Published
  10. Effects of repeated COX-2 inhibitor administration on synaptic transmission and plasticity in mice cortex and hippocampus
    Authors:
    Bobula Bartosz, Hess Grzegorz, Panczyszyn-Trzewik Patrycja, Misztak Paulina, Nowak Gabriel, Pilc Andrzej, Stachowicz Katarzyna
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudnia 2017
    Status:
    Published
    DOI:
    link to the publication
  11. NS-398 potentiates the antidepressant-like effect of MTEP in mice: Involvement of pro-inflammatory cytokine pathways in the brain
    Authors:
    M. Sowa-Kućma, P. Misztak, P. Pańczyszyn-Trzewik, A. Pilc, G. Nowak, K. Stachowicz
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  12. Behavioral consequences of chronic co-administration of mGluR5 antagonist (MTEP), and COX-2 inhibitor (NS398)
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak, Andrzej Pilc.
    Conference:
    16th International Forum on Mood and Anxiety Disorders, Rome, Italy (rok: 2016, ), Wydawca: IFMAD
    Data:
    konferencja 8-10.12.2016
    Status:
    Published

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