Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Involvement of cyclooxygenase 2 in antidepressant-like effects of metabotropic glutamatergic receptors group I.

2014/13/D/NZ7/00292

Keywords:

Depression mGluR COX-2 second messengers

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Stachowicz 

Number of co-investigators in the project: 6

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 759 250 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2020-02-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do transferu pół-suchego (PIERCE POWER BLOTTER WELCOM PK).
  2. pH-metr.
  3. Kamera cyfrowa.
  4. Komputer stacjonarny z oprogramowaniem (3 000 PLN)
  5. Rota Rod dla myszy (26 000 PLN)
  6. Klatka do mierzenia interakcji socjalnych u myszy (10 000 PLN)
  7. Druciana klatka - element wyposażenia do klatki do mierzenia interakcji socjalnych (4 000 PLN)
  8. Labirynt Barnes dla myszy, zestaw (37 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (12)
  1. Evidence for the interaction of COX-2 with mGluR5 in the regulation of PSD95 and DSCAM proteins, but not mTOR in the mouse hippocampus. The influence of oxidative stress mechanisms.
    Authors:
    Katarzyna Stachowicz, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Magdalena Sowa-Kućma
    Academic press:
    Pharmacology Biochemistry and Behavior (rok: 2021, tom: x, strony: x), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Magdalena Kusek, Tomasz Lenda, Krzysztof Tokarski
    Academic press:
    Brain Research (rok: 2021, tom: 1771, strony: 147660), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Behavioral consequences of the co-administration of MTEP and the COX-2 inhibitor, NS398 in mice. Part 1
    Authors:
    Katarzyna Stachowicz
    Academic press:
    Behavioural Brain Research (rok: 2019, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Upregulation of the mGlu5 receptor and COX-2 protein in the mouse brain after imipramine and NS398, searching for mechanisms of regulation.
    Authors:
    Katarzyna Stachowicz, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Tomasz Lenda, Szymon Rzeźniczek, Magdalena Sowa-Kućma
    Academic press:
    Neurochemistry International (rok: 2021, tom: x, strony: x), Wydawca: ELSEVIER
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Marcin Marciniak, Bartosz Bobula, Krzysztof Tokarski
    Academic press:
    Neuroscience Letters (rok: 2021, tom: 741, strony: 135435), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2020.135435 - link to the publication
  6. Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review
    Authors:
    Katarzyna Stachowicz
    Academic press:
    Biochemical Pharmacology (rok: 2021, tom: 192, strony: 114729), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bcp.2021.114729 - link to the publication
  7. NS398, a cyclooxygenase-2 inhibitor, reverses memory performance disrupted by imipramine in C57Bl/6J mice.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Krzysztof Tokarski
    Academic press:
    Brain Research (rok: 2020, tom: 146741, strony: in press), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.brainres.2020.146741 - link to the publication
  8. The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders. Review
    Authors:
    Stachowicz K.
    Academic press:
    Acta Neurobiol Exp (Wars). (rok: 2018, tom: 78, strony: 210-219), Wydawca: Polish Neuroscience Society/PTBUN/Poland
    Status:
    Published
    DOI:
    PMID: - link to the publication
  1. Effects of acute mGluR7 PAM on changes in short-time plasticity and mGluR7 levels after chronic treatment with mGluR5 antagonist and COX-2 inhibitor
    Authors:
    Bartosz Bobula, , Krzysztof Tokarski, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Andrzej Pilc, Katarzyna Stachowicz
    Conference:
    31st ECNP Congress Barcelona (rok: 2018, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 6-9 październik 2018
    Status:
    Published
    DOI:
    link to the publication
  2. NS-398 potentiates the antidepressant-like effect of MTEP in mice: Involvement of pro-inflammatory cytokine pathways in the brain
    Authors:
    M. Sowa-Kućma, P. Misztak, P. Pańczyszyn-Trzewik, A. Pilc, G. Nowak, K. Stachowicz
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  3. Synergism between mGluR5 and COX-2 in antidepressant-like action is associated with the alterations in NMDA receptors.
    Authors:
    Paulina Misztak, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Szymon Rzeźniczek, Gabriel Nowak, Andrzej Pilc, Katarzyna Stachowicz.
    Conference:
    16th International Forum on Mood and Anxiety Disorders, Rome, Italy (rok: 2016, ), Wydawca: IFMAD
    Data:
    konferencja 8-10.12.2016
    Status:
    Published
  4. The effects of co-administration of mGluR5 antagonist and COX-2 inhibitor on synaptic plasticity in the frontal cortex and hippocampus of mice
    Authors:
    Bobula Bartosz, Hess Grzegorz, Pańczyszyn-Trzewik Patrycja, Misztak Paulina, Nowak Gabriel, Pilc Andrzej, Stachowicz Katarzyna
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  5. Changes in serotonin and noradrenaline level in C57Bl/6J mice brain after chronic co-treatment of imipramine with NS398 (COX-2 inhibitor)
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Tomasz Lenda, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Gabriel Nowak, Andrzej Pilc
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudnia 2017
    Status:
    Published
    DOI:
    link to the publication
  6. Effect of chronic Imipramine with NS-398 (COX-2 inhibitor) injection on the level of BDNF in Hippocampus and Prefrontal Cortex of C57Bl/6J mice
    Authors:
    Paulina Misztak, Patrycja Panczyszyn-Trzewik, Magdalena Sowa-Kućma, Andrzej Pilc, Gabriel Nowak, Katarzyna Stachowicz
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudzień 2017
    Status:
    Published
    DOI:
    link to the publication
  7. Effects of repeated COX-2 inhibitor administration on synaptic transmission and plasticity in mice cortex and hippocampus
    Authors:
    Bobula Bartosz, Hess Grzegorz, Panczyszyn-Trzewik Patrycja, Misztak Paulina, Nowak Gabriel, Pilc Andrzej, Stachowicz Katarzyna
    Conference:
    17th International Forum on Mood and Anxiety Disorders, Madrid, Spain (rok: 2017, ), Wydawca: IFMAD
    Data:
    konferencja 14-17 grudnia 2017
    Status:
    Published
    DOI:
    link to the publication
  8. Chronic co-administration of mGluR5 antagonist (MTEP) with COX-2 inhibitor (NS398) affects DSCAM expression in pFC and Hp in C57Bl/6J mice
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Szymon Rzeźniczek, Gabriel Nowak, Andrzej Pilc
    Conference:
    30th ECNP Congress Paris, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 2-5 września 2017
    Status:
    Published
    DOI:
    link to the publication
  9. Chronic co-treatment of NS398 (COX-2 inhibitor) with MTEP changes strategy of mice in Barnes Maze, through membrane resistance variation.
    Authors:
    Katarzyna Stachowicz, Bartosz Bobula, Magdalena Kusek, Krzysztof Tokarski, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Andrzej Pilc
    Conference:
    ECNP Congress Barcelona, Hiszpania, (rok: 2018, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 6-9 październik 2018
    Status:
    Published
    DOI:
    link to the publication
  10. Co-administration of COX-2 inhibitor NS-398 enhances antidepressant effect of mGluR5 antagonist MTEP in mice
    Authors:
    P. Pańczyszyn-Trzewik, P. Misztak, M. Sowa-Kućma, B. Szewczyk, G. Nowak, A. Pilc, K. Stachowicz.
    Conference:
    ECNP Workshop on Neuropsychopharmacology for "Junior Scientists" in Europe, Nice, France (rok: 2017, ), Wydawca: European Neuropsychopharmacology
    Data:
    konferencja 9-12 Marca 2017
    Status:
    Published
  11. NS398 (COX-2 inhibitor) potentiates the antidepressant-like effects of MTEP (mGluR5 antagonist): Involvement of 5-HT system
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Tomasz Lenda, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Gabriel Nowak, Andrzej Pilc
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-31 sierpień 2017
    Status:
    Published
    DOI:
    link to the publication
  12. Behavioral consequences of chronic co-administration of mGluR5 antagonist (MTEP), and COX-2 inhibitor (NS398)
    Authors:
    Katarzyna Stachowicz, Magdalena Sowa-Kućma, Paulina Misztak, Patrycja Pańczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak, Andrzej Pilc.
    Conference:
    16th International Forum on Mood and Anxiety Disorders, Rome, Italy (rok: 2016, ), Wydawca: IFMAD
    Data:
    konferencja 8-10.12.2016
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy