Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functional dissection of three alpha(1)-adrenergic receptor subtypes in the effects of antidepressant drugs: exploitation of in vitro and in vivo genetic models.

2015/17/B/NZ7/03018

Keywords:

antidepressant drugs noradrenergic system depression KO mice cell lines gene ablation signaling pathways

Descriptors:

  • NZ7_14:
  • NZ3_7:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Irena Maria Nalepa 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 160 000 PLN

Project start date (Y-m-d): 2016-02-12

Project end date (Y-m-d): 2021-02-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (12)
  1. Antidepressants differentially regulate intracellular signaling from α1-adrenergic receptor subtypes in vitro
    Authors:
    Piotr Chmielarz, Justyna Kuśmierczyk, Katarzyna Rafa-Zabłocka, Katarzyna Chorązka, Marta Kowalska, Grzegorz Satała and Irena Nalepa
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4817 (1-18)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094817 - link to the publication
  2. The Differential Involvement of α1-Adrenoceptor Subtypes in the Molecular Effects of Antidepressant Drugs.
    Authors:
    Irena Nalepa, Katarzyna Chorązka, Grzegorz Kreiner, Agnieszka Zelek-Molik, Anna Haduch, Władysława Anna Daniel, Piotr Chmielarz, Katarzyna Maziarz, Justyna Kuśmierczyk, Michał Wilczkowski, Adam Bielawski, Marta Kowalska
    Academic press:
    International Journal of Molecular Sciences (rok: 2025, tom: 26 (21), strony: 10488 (1-37)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms262110488 - link to the publication
  1. The glycogen synthase kinase-3 phosphorylation is differently affected by chronic treatment with desipramine or milnacipran: study in alpha(1A)-adrenergic receptor knockout mice.
    Authors:
    Nalepa I., Chorązka K., Kuśmierczyk J., Zelek-Molik A, Kowalska K.
    Conference:
    The 7th Mediterranean Neuroscience Society Conference, MNS 2019, Marrakech, Morrocco (rok: 2019, ), Wydawca: Proceedings of MNS 2019, IUBMB Focused Meeting
    Data:
    konferencja 2019-06-23 / 27
    Status:
    Published
  2. Expression of selected signaling proteins in hippocampus of knock-out mice devoid of alpha1A- or alpha1B-adrenergic receptor subtypes.
    Authors:
    Chorązka K., Kuśmierczyk J., Zelek-Molik A., Kreiner G., Bagińska M., Nalepa I.
    Conference:
    30th ECNP Congress, Paryż, Francja (rok: 2017, ), Wydawca: Elsevier, Eur. Neuropsychopharmacol.
    Data:
    konferencja 2-5 September 2017
    Status:
    Published
  3. Knockout of alpha(1D)-adrenergic receptor affects the BDNF-ERK pathway in prefrontal cortex of mice brain: modulation by antidepressant drugs.
    Authors:
    Nalepa I., Chorązka K., Kuśmierczyk J., Śmiałek J., Kowalska M.
    Conference:
    19th WPA World Congress of Psychiatry Psychiatry and Mental Health: Global Inspirations, Locally Relevant Action, Lisbon, Portugal (rok: 2019, ), Wydawca: World Psychiatric Association, Lisbon
    Data:
    konferencja 2019-08-21 / 24
    Status:
    Published
  4. Importance of α1A-adrenergic receptor subtype for desipramine-evoked CaMKII phosphorylation in mice.
    Authors:
    Chorązka K., Zelek-Molik A., Kuśmierczyk J., Kreiner G., Bagińska M., Nalepa I.
    Conference:
    3rd Central European Biomedical Congress (CEBC) News on biomarker discovery and research innovations in medicine and biomedical sciences, Krakow, Poland (rok: 2018, ), Wydawca: 3rd CEBC, Kraków
    Data:
    konferencja 15 - 18 September
    Status:
    Published
  5. Changes in phentolamine binding potency in mice with α1A– or α1B–adrenergic receptors knock-out.
    Authors:
    Kusmierczyk K., Kowalska M., Chorązka K., Nalepa I.
    Conference:
    3rd Central European Biomedical Congress (CEBC) News on biomarker discovery and research innovations in medicine and biomedical sciences, Krakow. Poland (rok: 2018, ), Wydawca: 3rd CEBC, Krakow
    Data:
    konferencja 15 - 18 September
    Status:
    Published
  6. The difference in reactiveness of alpha(1)-adrenergic receptor subtypes after 24 twenty four hours exposure to antidepressant drugs
    Authors:
    Kusmierczyk J., Chmielarz P., Rafa-Zablocka K., Kowalska M., Nalepa I.
    Conference:
    The 6th Mediterranean Neuroscience Society (MNS) Meeting, St. Julian's, Malta (rok: 2017, ), Wydawca: Xjenza - Journal of Malta Chamber of Scientists
    Data:
    konferencja 12 – 15 .07
    Status:
    Published
  7. Differential susceptibility of the alpha(1)-adrenergic receptor subtypes to antidepressant drugs action: in vitro study.
    Authors:
    Kuśmierczyk J., Chmielarz P., Rafa-Zablocka K., Kowalska M., Nalepa I.
    Conference:
    30th ECNP Congress, Paryż, Francja (rok: 2017, ), Wydawca: Elsevier, Eur. Neuropsychopharmacol.
    Data:
    konferencja 2-5.09 s
    Status:
    Published
  8. Antidepressant-induced changes in phosphorylation of calcium/calmodulin-dependent protein kinase II in prefrontal cortex of alpha1B-adrenergic receptor knockout mice.
    Authors:
    Chorązka K., Zelek-Molik A., Kuśmierczyk J., Kreiner G., Bagińska M., Nalepa I.
    Conference:
    Federation of European Neuroscience Societies (FENS), 11th FENS Forum of Neuroscience, Berlin, Germany (rok: 2018, ), Wydawca: 11th FENS Forum, Berlin
    Data:
    konferencja 7 – 11 July
    Status:
    Published
  9. Effect of chronic treatment with desipramine or milnacipran on the glycogen synthase kinase-3 phosphorylation in cerebral prefrontal cortex: study in alpha1B-adrenergic receptor knockout mice.
    Authors:
    Nalepa I., Chorazka K., Zelek-Molik A., Kusmierczyk A., Kreiner G., Baginska M., Kowalska M.
    Conference:
    Collegium Internationale Neuro-Psychopharmacologicum (CINP) 31st World Congress of Neuropsychopharmacology, Vienna, Austria (rok: 2018, ), Wydawca: CINP 2018 Vienna World Congress
    Data:
    konferencja 16 - 19 June
    Status:
    Published
  10. Effect of desipramine on ERK1/2 protein expression and differential role of alpha1-adrenergic receptor subtypes in modulation of the ERK1/2 phosphorylation.
    Authors:
    Kuśmierczyk J., Chorązka K., Śmiałek J., Nalepa I.
    Conference:
    The 44th FEBS Congress - From Molecules to Living Systems, Krakow, Poland (rok: 2019, ), Wydawca: Wiley FEBS Press, FEBS Open Bio
    Data:
    konferencja 2019-07-06 / 11
    Status:
    Published
  11. Alpha1-adrenergic receptor subtypes modulate the ERK1/2 phosphorylation and differently participate in effect of chronically administered desipramine: study in knockout mice.
    Authors:
    Nalepa I., Chorązka K., Kuśmierczyk J., Zelek-Molik A., Sawa K., Kowalska M.
    Conference:
    The 32nd European College of Neuropsychopharmacology (ECNP) Congress, Copenhagen, Denmark (rok: 2019, ), Wydawca: Elsevier, Eur. Neuropsychopharmacol.
    Data:
    konferencja 2019-09-07 / 09
    Status:
    Published
  12. The difference in reactiveness of alpha(1)-adrenergic receptor subtypes after 24 prolonged incubation with antidepressant drugs.
    Authors:
    Kuśmierczyk J, Chmielarz P, Rafa-Zabłocka K, Kowalska M, Nalepa I
    Conference:
    Interdisciplinary Junior Scientists Workshop on Neuropharmacology and Molecular Biology, Białka Tatrzańska, Polska (rok: 2017, ), Wydawca: Instytut Farmakologii PAN, Kraków
    Data:
    konferencja 29.03-1.04.
    Status:
    Published

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