Projects funded by the NCN

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234 projects found matching your search criteria :

  1. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  2. Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  3. Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: prof. Sławomir Hubert Filipek

    Uniwersytet Warszawski, Wydział Chemii

  4. Metallosupramolecular architectures based on flexidentate pyridyl-β-diketonate ligands - synthesis, properties and catal...

    Call: PRELUDIUM 21 , Panel: ST4

    Principal investigator: Gracjan Piotr Kurpik

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

  5. Novel tricyclic glycomimetics as DC-SIGN receptor ligands.

    Call: OPUS 22 , Panel: ST4

    Principal investigator: dr Mykhaylo Potopnyk

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  6. Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

    Call: SONATA 17 , Panel: NZ3

    Principal investigator: dr Ewelina Barbara Honkisz-Orzechowska

    Uniwersytet Jagielloński, Collegium Medicum

  7. Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards prec...

    Call: OPUS 22 , Panel: NZ1

    Principal investigator: dr hab. Łukasz Opaliński

    Uniwersytet Wrocławski, Wydział Biotechnologii

  8. Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

    Uniwersytet Jagielloński, Collegium Medicum

  9. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Aleksandra Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  10. Reversible modulation of G-quadruplex functions using photoresponsive ligands - in vitro and cellular studies

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Marta Maria Dudek

    Politechnika Wrocławska

  11. The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

    Uniwersytet Jagielloński, Collegium Medicum

  12. True Bioisosteres - Structural and Thermodynamic Classification of Molecular Fragments for Ligand Design

    Call: SONATA BIS 11 , Panel: ST4

    Principal investigator: dr Maura Dagmara Malińska

    Uniwersytet Warszawski, Wydział Chemii

  13. Combating addiction by targeting α3β4*-nicotinic acetylcholine receptors

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: dr Ákos Nemecz

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

  14. Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

    Call: OPUS 21 , Panel: NZ1

    Principal investigator: prof. Elżbieta Beata Kierzek

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  15. First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Marcin Roman Kołaczkowski

    Uniwersytet Jagielloński, Collegium Medicum

  16. Wood from pine family (Pinaceae) native to Poland as a potent source of pharmacologically active lignans

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Andrzej Patyra

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  17. Advanced coordination materials designed on the basis of functional silsesquioxanes

    Call: OPUS 21 , Panel: ST5

    Principal investigator: dr hab. Beata Dudziec

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

  18. Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

    Call: OPUS 20 , Panel: ST4

    Principal investigator: dr hab. Paweł Aleksander Siedlecki

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  19. AXL receptor signaling in cancer cell growth and drug resistance

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: prof. Marta Elżbieta Miączyńska

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  20. Photodynamics of metal complexes with 2,6-bis(thiazol-2-yl)pyridine derivatives functionalized by aryls and N-donors as ...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Anna Maria Maroń

    Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

  21. Multifunctional character of copper(II) macrocyclic complexes – utilization in atom transfer radical polymerization (ATR...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Adam Paweł Gorczyński

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  22. The new methodology for better understanding of ligand-RNA interactions.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr Filip Artur Stefaniak

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  23. Silsesquioxanes as Multifunctional Ligands in Coordination Chemistry and Nano-Building Blocks for Hybrid Materials

    Call: OPUS 20 , Panel: ST4

    Principal investigator: dr hab. Łukasz John

    Uniwersytet Wrocławski, Wydział Chemii

  24. New therapies of opioid use disorder

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr Wojciech Barnaba Solecki

    Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

  25. Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Dorota Gudanis-Sobocińska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  26. Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small...

    Call: OPUS 20 , Panel: NZ1

    Principal investigator: prof. Elżbieta Beata Kierzek

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  27. The influence of environment on biomolecular function, structure and interactions.

    Call: SONATA BIS 10 , Panel: ST4

    Principal investigator: dr hab. Piotr Mikołaj Setny

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  28. New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: dr Przemysław Patryk Zaręba

    Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

  29. Investigation into the mechanism of regulation of nicotinic acetylcholine receptors

    Call: POLS , Panel: NZ3

    Principal investigator: dr Ákos Nemecz

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

  30. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Marta Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  31. Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Alicja Aleksandra Gawalska

    Uniwersytet Jagielloński, Collegium Medicum

  32. Interconversions of supramolecular architectures based on Schiff base ligands and transition metal ions as potential pro...

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: Martyna Szymańska

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  33. Structure-function relationship in fibroblast growth factor signaling

    Call: CEUS-UNISONO , Panel: NZ3

    Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

    Uniwersytet Wrocławski

  34. Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Andrzej Mikołaj Pilc

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  35. Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

    Call: SONATINA 4 , Panel: NZ7

    Principal investigator: Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  36. Role of the Intersubunit and Interdomain Interactions in the GABAA Receptor Modulation by Protons.

    Call: ETIUDA 8 , Panel: NZ1

    Principal investigator: Michał Adam Michałowski

    Uniwersytet Wrocławski, Wydział Nauk Biologicznych

  37. Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

    Call: SONATINA 4 , Panel: NZ1

    Principal investigator: dr Aleksandra Anna Twarda-Cłapa

    Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

  38. Do potential new MRGPRX2 ligands induce mastocytes degranulation in human?

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr hab. Grzegorz Porębski

    Uniwersytet Jagielloński, Collegium Medicum

  39. Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Adam Stasiulewicz

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  40. Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

    Call: MAESTRO 1 , Panel: NZ4

    Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  41. MXO2-ISOMER: in search of colour-changing photoswitchable materials based on 4th-row transition-metal complexes with sim...

    Call: PRELUDIUM BIS 1 , Panel: ST4

    Principal investigator: dr hab. Katarzyna Natalia Jarzembska

    Uniwersytet Warszawski, Wydział Chemii

  42. Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Kaja Urszula Karaś

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  43. Analysis of the conformations of organic compounds in macromolecular structures

    Call: PRELUDIUM 18 , Panel: ST6

    Principal investigator: Joanna Magdalena Macnar

    Uniwersytet Warszawski, Wydział Chemii

  44. Binding isotope effects as new, unique tool for studies of receptor - ligand interactions

    Call: MAESTRO 1 , Panel: ST4

    Principal investigator: prof. Piotr Paneth

    Politechnika Łódzka

  45. In search of new metalloporphyrinoid catalysts for functionalization of C(sp3)-H bonds

    Call: SONATA 15 , Panel: ST4

    Principal investigator: dr Karolina Dorota Hurej

    Uniwersytet Wrocławski, Wydział Chemii

  46. Bioconjugates labeled with alpha- and beta-particle emitting radionuclides as potential radiopharmaceuticals in Targeted...

    Call: SONATA BIS 9 , Panel: ST4

    Principal investigator: dr hab. Marek Pruszyński

    Instytut Chemii i Techniki Jądrowej

  47. Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  48. Study on the structure related dielectric properties and molecular dynamics of poly(dimethylsiloxane) crosslinked by met...

    Call: PRELUDIUM 17 , Panel: ST3

    Principal investigator: Angelika Kinga Wrzesińska

    Politechnika Łódzka, Wydział Chemiczny

  49. Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur...

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: Marcin Józef Drop

    Uniwersytet Jagielloński, Collegium Medicum

  50. Therapeutic potential of biased 5-HT7 receptor ligands in the treatment of depression

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: prof. Paweł Maria Zajdel

    Uniwersytet Jagielloński, Collegium Medicum

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