Role of tryptophan-derived AhR ligands in UVB-induced melanomagenesis - in vitro and in vivo studies
2015/17/D/NZ7/02170
Keywords
Descriptors
- NZ7_12: Prewencja chorób człowieka
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ5_3: Patogeneza chorób człowieka
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Medyczny w Lublinie, Wydział Nauk o Zdrowiu
Voivodeship: lubelskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
SONATA 9 – announced on 2015-03-16
- Amount awarded
- 752 800 PLN
- Project start date
- 2016-03-17
- Project end date
- 2020-12-16
- Project duration
- 57 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Automatyczny system do naświetlania promieniowaniem UVB ze stałym pomiarem pochłoniętej dawki promieniowania (Bio-Sun, Vilber). Cost: 147 000 PLN
- Inkubator CO2 do hodowli komórek w warunkach in vitro z podstawą na kółkach.
- chłodziarko-zamrażarka.
Information in the final report
Publication in academic press/journals (4)
-
Kynurenic acid and cancer: facts and controversies.
- Authors:
- Walczak K, Wnorowski A, Turski WA, Plech T.
- Academic press:
- Cellular and Molecular Life Sciences (CMLS) (year: 2019, volume: 2019, pages: [Epub ahead of print]), Publisher: Springer International Publishing
- Status:
- Published
- DOI:
- 10.1007/s00018-019-03332-w. – link to the publication
-
Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies
- Authors:
- Walczak K, Langner E, Makuch-Kocka A, Szelest M, Szalast K, Marciniak S, Plech T.
- Academic press:
- Internatiol Journal of Molecular Sciences (IJMS) (year: 2020, volume: 21, pages: 7946), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms21217946 – link to the publication
-
UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells
- Authors:
- Walczak K, Kazimierczak P, Szalast K, Plech T
- Academic press:
- International Journal of Molecular Sciences (IJMS) (year: 2021, volume: 22, pages: 7500), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22147500 – link to the publication
-
A new insight into the potential role of tryptophan-derived AhR ligands in skin physiological and pathological processes
- Authors:
- Szelest M, Walczak K, Plech T
- Academic press:
- International Journal of Molecular Sciences (IJMS) (year: 2021, volume: 22, pages: 1104), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22031104 – link to the publication
Articles in post-conference publications (2)
-
Tryptophan-derived AhR ligands inhibit proliferation and induce cell death of A375 and RPMI7951 melanoma cells
- Authors:
- Walczak K, Langner E, Szalast K, Marciniak S, Plech T.
- Conference:
- 20th International Congress of the Polish Pharmacological Society (year: 2019, pages: 125), Publisher: Polish Pharmacological Society
- Date:
- conference 5-7.06.2019
- Status:
- Published
-
The effect of tryptophan-derived AhR ligands on melanoma cell proliferation, migration and cell death
- Authors:
- Walczak K, Langner E, Marciniak S, Szalast K, Plech T
- Conference:
- ISCaM 2019 6th Annual Meeting, Cancer metabolic rewiring: Mapping the road to clinical translation (year: 2019, pages: 131), Publisher: ISCaM
- Date:
- conference 17-19.10.2019
- Status:
- Published