Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of tryptophan-derived AhR ligands in UVB-induced melanomagenesis - in vitro and in vivo studies

2015/17/D/NZ7/02170

Keywords:

AhR melanoma kynurenina kwas kynureninowy FICZ

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Nauk o Zdrowiu

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Walczak 

Number of co-investigators in the project: 5

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 752 800 PLN

Project start date (Y-m-d): 2016-03-17

Project end date (Y-m-d): 2020-12-16

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny system do naświetlania promieniowaniem UVB ze stałym pomiarem pochłoniętej dawki promieniowania (Bio-Sun, Vilber) (147 000 PLN)
  2. Inkubator CO2 do hodowli komórek w warunkach in vitro z podstawą na kółkach.
  3. chłodziarko-zamrażarka.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies
    Authors:
    Walczak K, Langner E, Makuch-Kocka A, Szelest M, Szalast K, Marciniak S, Plech T.
    Academic press:
    Internatiol Journal of Molecular Sciences (IJMS) (rok: 2020, tom: 21, strony: 7946), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217946 - link to the publication
  2. UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells
    Authors:
    Walczak K, Kazimierczak P, Szalast K, Plech T
    Academic press:
    International Journal of Molecular Sciences (IJMS) (rok: 2021, tom: 22, strony: 7500), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147500 - link to the publication
  3. A new insight into the potential role of tryptophan-derived AhR ligands in skin physiological and pathological processes
    Authors:
    Szelest M, Walczak K, Plech T
    Academic press:
    International Journal of Molecular Sciences (IJMS) (rok: 2021, tom: 22, strony: 1104), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22031104 - link to the publication
  4. Kynurenic acid and cancer: facts and controversies.
    Authors:
    Walczak K, Wnorowski A, Turski WA, Plech T.
    Academic press:
    Cellular and Molecular Life Sciences (CMLS) (rok: 2019, tom: 2019, strony: [Epub ahead of print]), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    10.1007/s00018-019-03332-w. - link to the publication
  1. The effect of tryptophan-derived AhR ligands on melanoma cell proliferation, migration and cell death
    Authors:
    Walczak K, Langner E, Marciniak S, Szalast K, Plech T
    Conference:
    ISCaM 2019 6th Annual Meeting, Cancer metabolic rewiring: Mapping the road to clinical translation (rok: 2019, ), Wydawca: ISCaM
    Data:
    konferencja 17-19.10.2019
    Status:
    Published
  2. Tryptophan-derived AhR ligands inhibit proliferation and induce cell death of A375 and RPMI7951 melanoma cells
    Authors:
    Walczak K, Langner E, Szalast K, Marciniak S, Plech T.
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 5-7.06.2019
    Status:
    Published

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