Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide binding protein

2016/21/N/ST4/03750

Keywords:

high-throughput method fluorescence polarization inhibitors enzyme 7-methylguanine

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_4: Theoretical and computational chemistry
  • NZ1_3: Biophysics

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Wojtczak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2017-02-02

Project end date (Y-m-d): 2019-02-01

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy
    Authors:
    Anna Wojtczak, Renata Kasprzyk, Marcin Warmiński, Krystian Ubych, Dorota Kubacka, Pawel J. Sikorski, Jacek Jemielity, Joanna Kowalska
    Academic press:
    Scientific Reports , Wydawca: Nature Publishing Group
    Status:
    Accepted for publication
    DOI:
    10.1038/s41598-021-87306-8 - link to the publication
  1. PODEJŚCIE WYSOKOPRZEPUSTOWE DO POSZUKIWANIA LIGANDÓW BIAŁKA eIF4E JAKO INHIBITORÓW BIOSYNTEZY BIAŁKA
    Authors:
    Anna Nowicka, Renata Kasprzyk, Marcin Warmiński, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity
    Conference:
    60 Zjazd naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17-21 września
    Status:
    Published
  2. Fluorescently labelled m7GpppG analogs as probes for fluorescence polarization studies – structure optimization and application
    Authors:
    Anna Nowicka, Marcin Warmiński, Renata Kasprzyk, Błażej Wojtczak, Dorota Kubacka, Joanna Kowalska, Jacek Jemielity
    Conference:
    XXIII INTERNATIONAL ROUNDTABLE ON NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS (rok: 2018, ), Wydawca: University of California, San Diego
    Data:
    konferencja 26-30.08.2018
    Status:
    Published
  3. Zastosowanie metody polaryzacji fluorescencji do poszukiwania silnych ligandów białek wiążących kap
    Authors:
    Anna Wojtczak, Renata kasprzyk, Dorota Kubacka, Radosław Wójcik, Marek R. Baranowski, Joanna Kowalska, Jacek Jemielity
    Conference:
    61. Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2018, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 17-21.09.2018
    Status:
    Published