Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Induction of human colon cancer cells apoptosis in vitro and in vivo by Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) produced and secreted by Lactococcus lactis bacteria

2014/15/B/NZ5/03484

Keywords:

apoptosis hsTRAIL colon cancer vector plasmid cancer immunotherapy Lactococcus lactis

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_3: Apoptosis
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jarosław Baran 

Number of co-investigators in the project: 7

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 770 225 PLN

Project start date (Y-m-d): 2015-09-09

Project end date (Y-m-d): 2020-03-08

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zamrażarka model GTL4905.
  2. System do rozdziału i transferu białek - Turbo blot.
  3. System do elektroporacji komórek eukariotycznych i prokariotycznych - Gene Pulser Xcell Total System (52 319 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Secretion of tumoricidal human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by recombinant Lactococcus lactis: optimization of in vitro synthesis conditions".
    Authors:
    K.Ciaćma, J.Więckiewicz, S.Kędracka-Krok, M.Kurtyka, M.Stec, M.Siedlar, J.Baran
    Academic press:
    Microbial Cell Factories (rok: 2018, tom: 0,83125, strony: 45307), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12934-018-1028-2 - link to the publication
  2. "The Anti-Tumor Effect of Lactococcus lactis Bacteria-Secreting Human Soluble TRAIL Can Be Enhanced by Metformin Both In Vitro and In Vivo in a Mouse Model of Human Colorectal Cancer".
    Authors:
    K.Kaczmarek, J.Więckiewicz, K.Węglarczyk, M.Siedlar, J.Baran
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13(12):3004, strony: 45316), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13123004 - link to the publication
  1. "Lactococcus lactis producing human tumor necrosis factor-related apoptosis-inducing ligand"
    Authors:
    Ciacma K., Wieckiewicz J., Weglarczyk K., Siedlar M., Baran J
    Conference:
    17th International Congress of Immunology (rok: 2019, ), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Data:
    konferencja 19-23.X.2019
    Status:
    Published
    DOI:
    link to the publication

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