The determination of ADME-Tox in vitro for potential CNS-drug candidates acting as potent and selective ligands of serotonin receptors 5-HT6
2016/21/N/NZ7/03265
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_15: Toksykologia
- NZ4_11: Metabolizm
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
PRELUDIUM 11 – announced on 2016-03-15
- Amount awarded
- 99 260 PLN
- Project start date
- 2017-04-14
- Project end date
- 2019-10-13
- Project duration
- 30 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Rotor SR-32. Cost: 188 PLN
- Worteks Combi-Spin (OT/42/2019). Cost: 1 562 PLN
- Worteks V-1 Plus. Cost: 874 PLN
- wirówka laboratoryjna. Cost: 3 500 PLN
Information in the final report
Publication in academic press/journals (3)
-
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6
- Authors:
- Wesam Ali, Małgorzata Więcek, Dorota Łażewska, Rafał Kurczab, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Katarzyna Kucwaj-Brysz, Annamaria Lubelska, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Muhammad Jawad Nasim, Anna Partyka, Gniewomir Latacz, Anna Wesołowska, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
- Academic press:
- European Journal of Medicinal Chemistry (year: 2019, volume: 178, pages: 740-751), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejmech.2019.06.022 – link to the publication
-
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
- Authors:
- Rafał Kurczab, Wesam Ali, Dorota Łażewska, Magdalena Kotańska, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Małgorzata Więcek, Annamaria Lubelska, Gniewomir Latacz, Anna Partyka, Małgorzata Starek, Monika Dąbrowska, Anna Wesołowska, Claus Jacob, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
- Academic press:
- Molecules (year: 2018, volume: 23, pages: 2529), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules23102529 – link to the publication
-
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
- Authors:
- Gniewomir Latacz, Annamaria Lubelska, Magdalena Jastrzębska-Więsek, Anna Partyka, Małgorzata Anna Marć, Grzegorz Satała, Daria Wilczyńska, Magdalena Kotańska, Małgorzata Więcek, Katarzyna Kamińska, Anna Wesołowska, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik
- Academic press:
- International Journal of Molecular Sciences (year: 2019, volume: 20, pages: 46043), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms20143420 – link to the publication