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Information of the project and the call

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An association of KIR, LILRB genes polymorphism and their ligands - HLA-C and HLA-G with recurrent implantation failure after in vitro fertilization.

2014/13/B/NZ5/00273

Keywords:

killer cell immunoglobulin-like receptor (KIR) (LILRB) human leucocyte antigen (HLA) recurrent implantation failure (RIF)

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ6_2: Clinical immunology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Izabela Nowak 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 002 600 PLN

Project start date (Y-m-d): 2015-02-18

Project end date (Y-m-d): 2020-02-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  1. KIR, LILRB and their ligands' genes as potential biomarkers in recurrent implantation failure
    Authors:
    Izabela Nowak, Karolina Wilczyńska, Jacek R. Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2017, tom: 65 (5), strony: 391-399), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-017-0474-6 - link to the publication
  2. Association of Soluble HLA-G Plasma Level and HLA-G Genetic Polymorphism With Pregnancy Outcome of Patients Undergoing in vitro Fertilization Embryo Transfer
    Authors:
    Nowak I, Wilczyńska K, Radwan P, Wiśniewski A, Krasiński R, Radwan M, Wilczyński JR, Malinowski A, Kuśnierczyk P.
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 10, strony: 2982), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02982. - link to the publication
  3. KIR and HLA-C genes in male infertility
    Authors:
    Karolina Wilczyńska, Paweł Radwan, Rafał Krasiński, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Ewa Barcz, Izabela Nowak
    Academic press:
    Journal of Assisted Reproduction and Genetics (rok: 2020, tom: 45432, strony: Online ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10815-020-01814-6 - link to the publication
  4. The methylenetetrahydrofolate reductase c.c.677 C>T and c.c.1298 A>C polymorphisms in reproductive failures: Experience from an RSA and RIF study on a Polish population.
    Authors:
    Nowak I, Bylińska A, Wilczyńska K, Wiśniewski A, Malinowski A, Wilczyński JR, Radwan P, Radwan M, Barcz E, Płoski R, Motak-Pochrzęst H, Banasik M, Sobczyński M, Kuśnierczyk P.
    Academic press:
    PLoS ONE (rok: 2017, tom: Oct 26;12(10), strony: e0186022), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0186022 - link to the publication
  1. New insights into HLA-G promoter genotyping
    Authors:
    Andrzej Wiśniewski, Marta Wagner, Andrzej Malinowski, Jacek R. Wilczyński, Michał Radwan, Paweł Radwan, Piotr Kuśnierczyk, Izabela Nowak
    Conference:
    10th East-West Immunogenetics Conference (EWIC) Wrocław 2016 (rok: 2016, ), Wydawca: Springer
    Data:
    konferencja 21.04.-23.04.2016
    Status:
    Published
  2. The study of genetic polyrnorphisrns for KIR2DL4, LILRB1, LILRB2 receptors and their ligand - HLA-G in recurrent implantation failure
    Authors:
    K. Wilczyńska, M. Jasek, M. Wagner, W. Niepiekło-Miniewska, A. Wiśniewski, P. Radwan, M. Radwan, J.R. Wilczyński, A. Malinowski, P. Kuśnierczyk, I. Nowak
    Conference:
    14th Conference of the European Society for Reproductive Immunology, Kos Greece 2017 (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 29.09-2.10.
    Status:
    Published
  3. Killer cell immunoglobulin-like receptor and HLA-C polymorphisms in recurrent implantation failure
    Authors:
    Karolina Wilczyńska, Paweł Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Ewa Barcz, Rafał Płoski, Piotr Kuśnierczyk, Izabela Nowak
    Conference:
    32nd European Immunogenetics and Histocompatibility Conference, Venice Lido Italy 2018 (rok: 2018, ), Wydawca: Willey, HLA. 2018;91:354–474.
    Data:
    konferencja 9.05.-12.05
    Status:
    Published
  4. Methylenetetrahydrofolate reductase polymorphisms and a risk of reproductive failures in Polish population
    Authors:
    Izabela Nowak, Aleksandra Bylińska, Andrzej Malinowski, Jacek R. Wilczyński, Paweł Radwan, Michał Radwan, Ewa Barcz, Piotr Kuśnierczyk
    Conference:
    The XVIth Congress of the Polish Society of Experimental and Clinical Immunology, Warszawa 2017 (rok: 2017, ), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 8-10.06.
    Status:
    Published
  5. Killer cell immunoglobulin-like receptor genes polymorphism in recurrent implantation failure following in vitro fertilization – a preliminary study
    Authors:
    Izabela Nowak, Karolina Wilczyńska, Adriana Jakubowska, Andrzej Malinowski, Jacek R. Wilczyński, Michał Radwan, Paweł Radwan, Piotr Kuśnierczyk
    Conference:
    V Polski Kongres Genetyki Łodź 2016 (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne, Polskie Towarzystwo Genetyki Człowieka
    Data:
    konferencja 19-22.09.
    Status:
    Published
  6. Recurrent implantation failure and soluble HLA-G plasma levels
    Authors:
    Andrzej Wiśniewski, Karolina Wilczyńska, Rafał Krasiński, Paweł Radwan, Michał Radwan, Jacek R. Wilczyński,Andrzej Malinowski, Piotr Kuśnierczyk, Izabela Nowak
    Conference:
    The XVIth Congress of the Polish Society of Experimenthal and Clinical Immunology, Warszawa 2017 (rok: 2017, ), Wydawca: Termedia Publishing House Ltd.
    Data:
    konferencja 8-10.06.
    Status:
    Published
  7. Recurrent implantation failure and soluble HLA-G plasma levels
    Authors:
    Wilczyńska K, Wiśniewski W, Krasiński R, Radwan P, Radwan M, Wilczyński JR, Malinowski A, Kuśnierczyk P, Nowak I.
    Conference:
    14th Conference of the European Society for Reproductive Immunology, Kos Greece 2017 (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja 29.09-2.10.
    Status:
    Published

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