Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

2011/03/N/ST4/01293

Keywords:

cystatin C NMR structure inhibitor Ab SAA fibrilization

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_15: Colloid chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Martyna Maszota-Zieleniak 

Number of co-investigators in the project: 3

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 311 300 PLN

Project start date (Y-m-d): 2012-09-14

Project end date (Y-m-d): 2017-05-13

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw komputerowy (2 szt.) (8 000 PLN)
  2. Urządzenie wielofunkcyjne (2 000 PLN)
  3. Cieplarka.
  4. Waga mikroanalityczna (10 000 PLN)
  5. Notebook.
  6. Suszarka (5 000 PLN)
  7. pH metr oraz dwie elektrody, w tym jedna zwykła (5mm) oraz druga, przystosowana do kuwet NMR (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution
    Authors:
    Martyna Maszota -Zieleniak, Przemysław Jurczak, Marta Orlikowska, Igor Zhukov, Dominika Borek, Zbyszek Otwinowski, Piotr Skowron, Zuzanna Pietralik, Maciej Kozak, Aneta Szymańska, Sylwia Rodziewicz -Motowidło
    Academic press:
    The FEBS Jurnal (rok: 2019, ), Wydawca: WILEY-BLACKWELL
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Human cystatin C monomer, dimer, oligomer, and amyloid structures are related to health and disease
    Authors:
    Przemysław Jurczak, Patrick Groves, Aneta Szymańska, Sylwia Rodziewicz-Motowidło
    Academic press:
    FEBS Letters (rok: 2016, tom: 590, strony: 4192-4201), Wydawca: FEBS Press
    Status:
    Published
    DOI:
    10.1002/1873-3468.12463 - link to the publication
  1. NMR Studies of Human Cystatin C – Stable Isotope Labeling of Human Cystatin C
    Authors:
    Przemysław Jurczak, Martyna Maszota-Zieleniak
    Conference:
    CBSB14 Conference (rok: 2014, ), Wydawca: Academic Computer Centre in Gdansk
    Data:
    konferencja 25-27.05.2014
    Status:
    Published
    DOI:
    link to the publication

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