Projects funded by the NCN
The role of halogen bonding in interaction of ligands with SERT.
2016/21/D/NZ7/00620
Keywords:
haloden bonds SERT serotonin 5-HT6 5-HT7 depression
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
- ST5_16:
- NZ2_7: Bioinformatics
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 11 - announced on 2016-03-15
Amount awarded: 383 500 PLN
Project start date (Y-m-d): 2017-03-31
Project end date (Y-m-d): 2020-03-30
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamineAuthors:Jakub Staron*, Wojciech Pietrus, Ryszard Bugno, RafałKurczab, Grzegorz Satała, Dawid Warszycki, Tomasz Lenda, Anna Wantuch, Adam S. Hogendorf, Agata Hogendorf, Beata Duszynska, Andrzej J. BojarskiAcademic press:European Journal of Medicinal Chemistry (rok: 2021, tom: 220, strony: 113533), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2021.113533 - link to the publication