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The effects of ligands of the alpha7 nicotinic acetylcholine receptors on complex cognitive processes and social behaviour in the neurodevelopmental schizophrenia-like model.

2014/15/N/NZ7/02978

Keywords:

schizophrenia cognition social bahaviour nicotinic receptors allosteric modulation animal models

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Potasiewicz 

Number of co-investigators in the project: 3

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 99 966 PLN

Project start date (Y-m-d): 2015-09-10

Project end date (Y-m-d): 2018-06-09

Project duration:: 33 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (12)
  1. Evaluation of ultrasonic vocalisations in a neurodevelopmental model of schizophrenia at early life stages in rats
    Authors:
    Agnieszka Potasiewicz, Małgorzata Hołuj, Diana Piotrowska, Katarzyna Zajda, Michał Wójcik, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    Neuropharmacology (rok: 2019, tom: 146, strony: 28-38), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2018.11.023 - link to the publication
  2. Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
    Academic press:
    Journal of Psychopharmacology (rok: 2017, tom: 31, strony: 260-271), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/0269881116675509 - link to the publication
  1. Prenatal exposure to methylazoxymethanol acetate: effect on pups' ultrasound vocalisations and homing behaviour.
    Authors:
    Potasiewicz Agnieszka, Piotrowska Diana, Zajda Katarzyna, Popik Piotr, Nikiforuk Agnieszka
    Conference:
    FENS-SFN SUMMER SCHOOL 2017 Chemical Neuromodulation: Neurobiological, Neurocomputational, Behavioural And Clinical Aspects" (rok: 2017, ), Wydawca: FENS - Federation of European Neuroscience Societies
    Data:
    konferencja 14-24 czerwiec
    Status:
    Published
    DOI:
    link to the publication
  2. The ligands of alpha7 nicotinic acetylcholine receptors improve memory processes and social behaviours in the neurodevelopmental model of schizophrenia
    Authors:
    Agnieszka Potasiewicz, Małgorzata Hołuj, Piotr Popik, Agnieszka Nikiforuk
    Conference:
    Neuronus 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 20-22 kwiecień
    Status:
    Published
  3. Reduced social interaction and ultrasound vocalisations in neurodevelopmental model of schizophrenia
    Authors:
    Potasiewicz Agnieszka, Hołuj Malgorzata, Piotrowska Diana, Zajda Katarzyna, Popik Piotr, Nikiforuk Agnieszka
    Conference:
    EBPS Biennial Meeting (rok: 2017, ), Wydawca: EBPS (European Behavioural Pharmacology Society)
    Data:
    konferencja 31 sierpień-3 wrzesień
    Status:
    Published
  4. Sex differences in animal model of schizophrenia.
    Authors:
    Potasiewicz Agnieszka, Nikiforuk Agnieszka, Hołuj Małgorzata, Popik Piotr
    Conference:
    Interdisciplinary Junior Scientists Workshop On Neuropharmacology And Molecular Biology (rok: 2017, ), Wydawca: IFPAN
    Data:
    konferencja 29 marzec-01 kwiecień
    Status:
    Published
  5. The effects of ligands of the alpha7 nicotinic acetylcholine receptors on impaired memory and social behaviours in the neurodevelopmental model of schizophrenia.
    Authors:
    Agnieszka Potasiewicz , Małgorzata Hołuj, Piotr Popik, Agnieszka Nikiforuk
    Conference:
    ECNP Congresses (rok: 2019, ), Wydawca: Elsevier; European Neuropsychopharmacology
    Data:
    konferencja 06-09 październik
    Status:
    Published
    DOI:
    link to the publication
  6. The effects of positive allosteric modulator of α7 nicotinic receptors on cognitive and sensorimotor gating deficits in a schizophrenia-like model in rats.
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
    Conference:
    5th Biennial Schizophrenia International Research Society Conference (rok: 2016, ), Wydawca: npj Schizophrenia
    Data:
    konferencja 02-04 kwiecień
    Status:
    Published
  7. The role of alpha 7 nicotinic acetylcholine receptors in the modulation of attention in rats.
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Piotr Popik
    Conference:
    NEURONUS 2016 IBRO & IRUN (rok: 2016, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 22-24 kwiecień
    Status:
    Published
  8. Effect of prenatal exposure to methylazoxymethanol acetate on pups' ultrasound vocalisations.
    Authors:
    Piotrowska D., Potasiewicz A., Popik P., Nikiforuk A.
    Conference:
    7th International Conference Aspects of Neuroscience (rok: 2017, ), Wydawca: Aspects of Neuroscience Conference materials
    Data:
    konferencja 24-26 listopad
    Status:
    Published
  9. Effects of prenatal exposure to methylazoxymethanol acetate on the juvenile social play behavior and ultrasonic communication in male and female rats
    Authors:
    Małgorzata Hołuj, Agnieszka Potasiewicz, Michał Wójcik and Piotr Popik
    Conference:
    ECNP Congress (rok: 2019, ), Wydawca: Elsevier; European Neuropsychopharmacology
    Data:
    konferencja 06-09 październik
    Status:
    Published
    DOI:
    link to the publication
  10. Positive allosteric modulators of alpha7 nicotinic acetylcholine receptor enhance memory processes.
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Martyna Krawczyk, Tomasz Kos, Piotr Popik
    Conference:
    2nd Central European Biomedical Congress (rok: 2016, ), Wydawca: Central European Biomedical Congress
    Data:
    konferencja 15-18 czerwiec
    Status:
    Published
    DOI:
    link to the publication
  11. The evaluation of the animal model of schizophrenia in female and male rats.
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
    Conference:
    TRANSLATIONAL NEUROSCIENCE AND MENTAL DISORDERS: Bridging the gap between animal models and human condition. (rok: 2016, ), Wydawca: brak
    Data:
    konferencja 4-9 listopad
    Status:
    Published
  12. Prenatal exposure to methylazoxymetanol acetate alters pups' ultrasonic vocalisation
    Authors:
    Diana Piotrowska, Agnieszka Potasiewicz, Agnieszka Nikiforuk, Piotr Popik
    Conference:
    Neuronus 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 22-25 kwiecień
    Status:
    Published

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