Synthesis and biological evaluation of novel, drug-like multifunctional ligands,

Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents targeting cholinesterases and beta-secretase.

2016/21/N/NZ7/03288

Keywords

Descriptors

NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Dawid Marcin Panek

Number of co-investigators in the project: 2

Call

PRELUDIUM 11 – announced on 2016-03-15

Amount awarded: 49 990 PLN
Project start date: 2017-04-13
Project end date: 2018-08-12
Project duration: 16 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3- Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

Authors:
Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara Malawska

Academic press:
Molecules (year: 2018, volume: 23(2), pages: 46037), Publisher: MDPI

Status:
Published

DOI:
10.3390/molecules23020347. – link to the publication
Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2- hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents

Authors:
Dawid Panek, Anna Więckowska, Jakub Jończyk, Justyna Godyn, Marek Bajda, Tomasz Wichur, Anna Pasieka, Damijan Knez, Anja Pislar, Jan Korabecny, Ondrej Soukup, Vendula Sepsova, Raimon Sabate, Janko Kos, Stanislav Gobec, Barbara Malawska*

Academic press:
ACS Chemical Neuroscience (year: 2018, volume: 9 (5), pages: 1074–1094), Publisher: American Chemical Society

Status:
Published

DOI:
10.1021/acschemneuro.7b00461 – link to the publication

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