Projects funded by the NCN
Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents targeting cholinesterases and beta-secretase.
2016/21/N/NZ7/03288
Keywords:
β-secretase acetylcholinesterase butyrylcholinesterase Alzheimer Disease organic synthesis inhibition of β-amyloid agregation
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 11 - announced on 2016-03-15
Amount awarded: 49 990 PLN
Project start date (Y-m-d): 2017-04-13
Project end date (Y-m-d): 2018-08-12
Project duration:: 16 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3- Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer AgentsAuthors:Dawid Panek, Anna Więckowska, Anna Pasieka, Justyna Godyń, Jakub Jończyk, Marek Bajda, Damijan Knez, Stanislav Gobec, Barbara MalawskaAcademic press:Molecules (rok: 2018, tom: 23(2), strony: 45306), Wydawca: MDPIStatus:PublishedDOI:10.3390/molecules23020347. - link to the publication
- Design, Synthesis, and Biological Evaluation of 1‑Benzylamino-2- hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's AgentsAuthors:Dawid Panek, Anna Więckowska, Jakub Jończyk, Justyna Godyn, Marek Bajda, Tomasz Wichur, Anna Pasieka, Damijan Knez, Anja Pislar, Jan Korabecny, Ondrej Soukup, Vendula Sepsova, Raimon Sabate, Janko Kos, Stanislav Gobec, Barbara Malawska*Academic press:ACS Chemical Neuroscience (rok: 2018, tom: 9 (5), strony: 1074–1094), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acschemneuro.7b00461 - link to the publication