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The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

2016/23/B/NZ7/01131

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Agnieszka Anna Nikiforuk

Number of co-investigators in the project: 7

Call

OPUS 12 – announced on 2016-09-15

Amount awarded
937 600 PLN
Project start date
2017-07-25
Project end date
2022-07-24
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zestaw do nagrywania i analizy wokalizacji ultradżwiękowych Avisoft Bioacoustics. Cost: 70 000 PLN
  2. zestaw do nagrywania i analizy zachowań zwierząt EthoVision XT (Noldus). Cost: 85 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. Astroglia in Autism Spectrum Disorder

    Authors:
    Kinga Gzielo, Agnieszka Nikiforuk
    Academic press:
    Int J Mol Sci (year: 2021, volume: 22, pages: 11544), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111544 – link to the publication

  2. The Effect of Maternal Immune Activation on Social Play-Induced Ultrasonic Vocalization in Rats

    Authors:
    Kinga Gzielo, Agnieszka Potasiewicz , Ewa Litwa, Diana Piotrowska, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    Brain Sci (year: 2021, volume: 11(3), pages: 344), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci11030344 – link to the publication

  3. Effects of prenatal exposure to valproic acid or poly(I:C) on ultrasonic vocalizations in rat pups: The role of social cues

    Authors:
    Agnieszka Potasiewicz, Kinga Gzielo , Piotr Popik , Agnieszka Nikiforuk
    Academic press:
    Physiology & Behavior (year: 2020, volume: 225, pages: 113113), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.physbeh.2020.113113 – link to the publication

  4. Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats

    Authors:
    Kinga Gzielo, Agnieszka Potasiewicz, Małgorzata Hołuj, Ewa Litwa, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    European Neuropsychopharmacology (year: 2020, volume: 41, pages: 52-62), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.euroneuro.2020.09.006 – link to the publication

  5. Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies

    Authors:
    Agnieszka Potasiewicz, Malgorzata Holuj, Ewa Litwa, Kinga Gzielo, Lucyna Socha, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    Neuropharmacology (year: 2020, volume: 170, pages: 108040), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2020.108040 – link to the publication

  6. Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats.

    Authors:
    Agnieszka Nikiforuk, Ewa Litwa, Martyna Krawczyk, Piotr Popik, Hugo Arias
    Academic press:
    Pharmacological Reports (year: 2020, volume: 72(3), pages: 589-599), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00092-4 – link to the publication

  7. Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats

    Authors:
    Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik , Agnieszka Nikiforuk
    Academic press:
    Behav Brain Res (year: 2021, volume: 409, pages: 113338), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2021.113338 – link to the publication

  8. Procognitive effects of varenicline in the animal model of schizophrenia depend on α4β2- and α 7-nicotinic acetylcholine receptors.

    Authors:
    Potasiewicz A, Golebiowska J, Popik P, Nikiforuk A
    Academic press:
    J Psychopharmacol (year: 2019, volume: brak, pages: brak), Publisher: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/0269881118812097. – link to the publication

Articles in post-conference publications (2)

  1. Social play behavior of rats in the model of autism induced by prenatal exposure to polyinosinic: polycytidylic acid

    Authors:
    K Gzielo, M Holuj, P Popik, A Nikiforuk
    Conference:
    14 th International Congress of the Polish Neuroscience Society, Katowice (year: 2019, pages: 79 (Suppl. 1): XLVI-XLVII), Publisher: Acta Neurobiologiae Experimentalis 79 (Suppl. 1)
    Date:
    conference 43705
    Status:
    Published

  2. Pups' altered ultrasonic vocalisation in the poly I: C rat model of autism spectrum disorder: results from the mother isolation test

    Authors:
    D Piotrowska, J Sopel, A Potasiewicz, P Popik, A Nikiforuk
    Conference:
    14 th International Congress of the Polish Neuroscience Society, Katowice (year: 2019, pages: 79 (Suppl. 1):LXXIV-LXXV), Publisher: Acta Neurobiologiae Experimentalis 79 (Suppl. 1)
    Date:
    conference 43705
    Status:
    Published

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