Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

2016/23/B/NZ7/01131

Keywords:

autism animal models nicotinic receptors allosteric modulation social deficits ultrasonic communication cognition

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Nikiforuk 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 937 600 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2022-07-24

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zestaw do nagrywania i analizy zachowań zwierząt EthoVision XT (Noldus) (85 000 PLN)
  2. zestaw do nagrywania i analizy wokalizacji ultradżwiękowych Avisoft Bioacoustics (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (2)
  1. Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats.
    Authors:
    Agnieszka Nikiforuk, Ewa Litwa, Martyna Krawczyk, Piotr Popik, Hugo Arias
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72(3), strony: 589-599), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00092-4 - link to the publication
  2. Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies
    Authors:
    Agnieszka Potasiewicz, Malgorzata Holuj, Ewa Litwa, Kinga Gzielo, Lucyna Socha, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    Neuropharmacology (rok: 2020, tom: 170, strony: 108040), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2020.108040 - link to the publication
  3. Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats
    Authors:
    Kinga Gzielo, Agnieszka Potasiewicz, Małgorzata Hołuj, Ewa Litwa, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    European Neuropsychopharmacology (rok: 2020, tom: 41, strony: 52-62), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.euroneuro.2020.09.006 - link to the publication
  4. Astroglia in Autism Spectrum Disorder
    Authors:
    Kinga Gzielo, Agnieszka Nikiforuk
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22, strony: 11544), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111544 - link to the publication
  5. Effects of prenatal exposure to valproic acid or poly(I:C) on ultrasonic vocalizations in rat pups: The role of social cues
    Authors:
    Agnieszka Potasiewicz, Kinga Gzielo , Piotr Popik , Agnieszka Nikiforuk
    Academic press:
    Physiology & Behavior (rok: 2020, tom: 225, strony: 113113), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.physbeh.2020.113113 - link to the publication
  6. Procognitive effects of varenicline in the animal model of schizophrenia depend on α4β2- and α 7-nicotinic acetylcholine receptors.
    Authors:
    Potasiewicz A, Golebiowska J, Popik P, Nikiforuk A
    Academic press:
    J Psychopharmacol (rok: 2019, tom: brak, strony: brak), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/0269881118812097. - link to the publication
  7. Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats
    Authors:
    Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik , Agnieszka Nikiforuk
    Academic press:
    Behav Brain Res (rok: 2021, tom: 409, strony: 113338), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2021.113338 - link to the publication
  8. The Effect of Maternal Immune Activation on Social Play-Induced Ultrasonic Vocalization in Rats
    Authors:
    Kinga Gzielo, Agnieszka Potasiewicz , Ewa Litwa, Diana Piotrowska, Piotr Popik, Agnieszka Nikiforuk
    Academic press:
    Brain Sci (rok: 2021, tom: 11(3), strony: 344), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci11030344 - link to the publication
  1. Pups' altered ultrasonic vocalisation in the poly I: C rat model of autism spectrum disorder: results from the mother isolation test
    Authors:
    D Piotrowska, J Sopel, A Potasiewicz, P Popik, A Nikiforuk
    Conference:
    14 th International Congress of the Polish Neuroscience Society, Katowice (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis 79 (Suppl. 1)
    Data:
    konferencja 43705
    Status:
    Published
  2. Social play behavior of rats in the model of autism induced by prenatal exposure to polyinosinic: polycytidylic acid
    Authors:
    K Gzielo, M Holuj, P Popik, A Nikiforuk
    Conference:
    14 th International Congress of the Polish Neuroscience Society, Katowice (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis 79 (Suppl. 1)
    Data:
    konferencja 43705
    Status:
    Published

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