Projects funded by the NCN
Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1 pathway
2015/19/N/ST5/00347
Keywords:
PD-1 PD-L1 NMR spectroscopy chemical probe multicomponent reactions
Descriptors:
- ST5_16:
- NZ1_2: Biochemistry
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Uniwersytet Jagielloński, Wydział Chemii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 10 - announced on 2015-09-15
Amount awarded: 50 000 PLN
Project start date (Y-m-d): 2016-07-21
Project end date (Y-m-d): 2017-07-20
Project duration:: 12 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cellsAuthors:Lukasz Skalniak , Krzysztof Zak , Katarzyna Guzik , Katarzyna Magiera , Bogdan Musielak , Magdalena Pachota , Bozena Szelazek , Justyna Kocik , Przemyslaw Grudnik , Marcin Tomala , Sylwia Krzanik , Krzysztof Pyrc , Alexander Dömling , Grzegorz DubinAcademic press:Oncotarget (rok: 2017, tom: -, strony: 45305), Wydawca: Impact JournalsStatus:PublishedDOI:10.18632/oncotarget.20050 - link to the publication
- Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1Authors:Katarzyna Guzik, Krzysztof M. Zak, Przemyslaw Grudnik, Katarzyna Magiera, Bogdan Musielak, Ricarda Törner, Lukasz Skalniak, Alexander Dömling, Grzegorz Dubin, Tad A. HolakAcademic press:Journal of Medicinal Chemistry (rok: 2017, tom: 60, strony: 5857–5867), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.jmedchem.7b00293 - link to the publication