Synthesis and Struktural Characterization of Small-Molecule Probes for the Progr

Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1 pathway

2015/19/N/ST5/00347

Keywords

Descriptors

ST5_16: Chemia biologiczna
NZ1_2: Biochemia

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Jagielloński, Wydział Chemii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Katarzyna Agnieszka Guzik

Number of co-investigators in the project: 2

Call

PRELUDIUM 10 – announced on 2015-09-15

Amount awarded: 50 000 PLN
Project start date: 2016-07-21
Project end date: 2017-07-20
Project duration: 12 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Authors:
Katarzyna Guzik, Krzysztof M. Zak, Przemyslaw Grudnik, Katarzyna Magiera, Bogdan Musielak, Ricarda Törner, Lukasz Skalniak, Alexander Dömling, Grzegorz Dubin, Tad A. Holak

Academic press:
Journal of Medicinal Chemistry (year: 2017, volume: 60, pages: 5857–5867), Publisher: American Chemical Society

Status:
Published

DOI:
10.1021/acs.jmedchem.7b00293 – link to the publication
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Authors:
Lukasz Skalniak , Krzysztof Zak , Katarzyna Guzik , Katarzyna Magiera , Bogdan Musielak , Magdalena Pachota , Bozena Szelazek , Justyna Kocik , Przemyslaw Grudnik , Marcin Tomala , Sylwia Krzanik , Krzysztof Pyrc , Alexander Dömling , Grzegorz Dubin

Academic press:
Oncotarget (year: 2017, volume: -, pages: 46036), Publisher: Impact Journals

Status:
Published

DOI:
10.18632/oncotarget.20050 – link to the publication

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