Projects funded by the NCN

Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr Michał Andrzej Abram

Uniwersytet Jagielloński

Uncovering the Molecular Basis of Carbon and Nitrogen Metabolic Integration via the Glutamate Pathway in Yarrowia lipoly...

Call: PRELUDIUM 24 , Panel: NZ9

Principal investigator: Kacper Patryk Szymański

Uniwersytet Przyrodniczy we Wrocławiu

Determination of the effect of volume regulated anion channels (VRACs) on the neurovascular unit under ischemic conditio...

Call: OPUS 27 , Panel: NZ5

Principal investigator: prof. Joanna Maria Pera

Uniwersytet Jagielloński

Role of Astrocytes in Chronic Stress Resilience

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr Piotr Marian Michaluk

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Potential pharmacological strategies aimed at alleviating cognitive dysfunctions accompanying oncological therapy while ...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński, Collegium Medicum

Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Ewa Monika Szymańska

Uniwersytet Jagielloński, Collegium Medicum

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

The role of nitric oxide-dependent pathways in the procognitive effects of muscarinic and metabotropic glutamate recepto...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Genesis of dendritic spine head protrusion (SHP) formation

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: Ewa Blanka Bączyńska

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

Interdisciplinary approach to the role of the GABA-ergic and glutamatergic neurotransmission in the effects of mephedron...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Barbara Izabela Budzyńska

Uniwersytet Medyczny w Lublinie, Wydział Biomedyczny

Investigation of the mechanisms of the neuroprotective effect of group II metabotropic receptors (mGluR2/3) agonist in a...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: dr Ewelina Małgorzata Bratek

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Role of glutamine synthesis in the initial phase of temporal lobe epilepsy in the juvenile rat lithium-pilocarpine model...

Call: OPUS 12 , Panel: NZ4

Principal investigator: prof. Jan Albrecht

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

Call: OPUS 11 , Panel: NZ7

Principal investigator: dr hab. Magdalena Jolanta Sowa-Kućma

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

Pharmacological properties and neurotoxicity of novel NBOMe derivatives

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Krystyna Czesława Gołembiowska

Instytut Farmakologii PAN

The effect of the metabotropic glutamatergic receptor ligands on potentiating the antidepressant-like actvity of scopola...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Karolina Sylwia Podkowa

Instytut Farmakologii PAN

Effects of maternal high-fat or high-sugar diet on the impaired NMDA receptor composition and regulation in offspring in...

Call: SONATA 10 , Panel: NZ7

Principal investigator: dr hab. Lucyna Pomierny-Chamioło

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resist...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Study of SNAP-25 protein expression, NMR metabolomic analysis and behavioral characteristics in animal models of infanti...

Call: OPUS 8 , Panel: NZ4

Principal investigator: prof. Jerzy Wiesław Łazarewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Participation of transient receptor potential (TRP) channels premeable for calcium ions in memory formation and retrieva...

Call: OPUS 8 , Panel: NZ4

Principal investigator: dr hab. Elżbieta Jolanta Salińska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

New selective antagonists of ionotropic glutamate non-NMDA receptors

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Ewa Monika Szymańska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

The mechanism of neurotoxic action of benzophenone-3

Call: OPUS 8 , Panel: NZ7

Principal investigator: prof. Bogusława Budziszewska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

Searching for molecular basis of addiction-prone phenotype - a role of astrocyte biomarkers (xc-, EAAT2) and metabotropi...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Ewa Magdalena Niedzielska-Andres

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural,...

Call: OPUS 6 , Panel: NZ4

Principal investigator: dr hab. Jadwiga Wardas

Instytut Farmakologii PAN

New 1,3,4-thiadiazole derivatives as inhibitors of critical steps of the glutamine-glutamate cycle in glioblastoma cells...

Call: SONATA 6 , Panel: NZ7

Principal investigator: dr hab. Monika Paulina Szeliga

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Contribution of the glutamate-mediated transmission changes in pedunculopontine tegmental nucleus and nucleus accumbens ...

Call: PRELUDIUM 5 , Panel: NZ4

Principal investigator: Karolina Plucińska

Uniwersytet Gdański, Wydział Biologii

Role of astrocytic NMDA receptors in ammonia-induced brain edema associated with hepatic encephalopathy.

Call: HARMONIA 4 , Panel: NZ3

Principal investigator: prof. Jan Albrecht

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The group III metabotropic glutamate receptors as a target for future antypsychotic drugs

Call: MAESTRO 3 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii PAN

The role of the mGlu5-D2 heterodimeric receptor complexes in the extinction of drug seeking behavior associated with dep...

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Małgorzata Frankowska

Instytut Farmakologii PAN, Instytut Farmakologii Polskiej Akademii Nauk