Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural, neurochemical and molecular studies in rats

2013/11/B/NZ4/04565

Keywords:

thalamic nuclei essential tremor parkinsonian tremor adenosine A1 and A2A receptors glutamate GABA

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jadwiga Wardas 

Number of co-investigators in the project: 7

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 875 450 PLN

Project start date (Y-m-d): 2014-08-21

Project end date (Y-m-d): 2018-08-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer stacjonarny Dell Vostro 3268 SFFz klawiaturą, myszą i monitorem (3 872 PLN)
  2. Homogenizator o wysokiej przepustowości umożliwiający lizę tkanek przeznaczonych do badań molekularnych (37 500 PLN)
  3. Urządzenie do krojenia mózgu ma skrawki o grubości 1 mm (3 500 PLN)
  4. System MCID slużący do zaawansowanej analizy obrazu (107 500 PLN)
  5. Spektrofotometr UV/Vis wraz z oprogramowaniem do analizy kwasów DNA, RNA oraz białek (42 500 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (6)
  1. Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor
    Authors:
    Kosmowska B, Ossowska K, Konieczny J, Lenda T, Berghauzen-Maciejewska K, Wardas J.
    Academic press:
    Neuroscience (rok: 2020, tom: 429, strony: 106-118), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2019.12.045 - link to the publication
  2. Tremorolytic effect of 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline-induced model in rats
    Authors:
    Kosmowska B., Ossowska K., Głowacka U., Wardas J.
    Academic press:
    CNS Neuroscience & Therapeutics (rok: 2017, tom: Vol. 23 No. 5, strony: 438-446), Wydawca: Wiley Online Library – John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/cns.12692 - link to the publication
  3. Pramipexole reduces zif-268 mRNA expression in brain structures involved in the generation of harmaline-induced tremor
    Authors:
    Kosmowska B., Ossowska K. and Wardas J.
    Academic press:
    Neurochemical Research (rok: 2020, ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s11064-020-03010-5 - link to the publication
  4. Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats
    Authors:
    Kosmowska B, Wardas J, Głowacka U, Ananatham S, Ossowska K
    Academic press:
    CNS Neuroscience & Therapeutics (rok: 2016, tom: Vol. 22, No. 1, strony: 53-62), Wydawca: Wiley Online Library - John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/cns.12467 - link to the publication
  1. 5'-chloror-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, inhibits the harmaline-induced tremor and zif-268 mRNA expression in rats.
    Authors:
    Kosmowska B., Ossowska K., Głowacka U., Wardas J.
    Conference:
    11th World Controversies in Neurology (CONy) Athens, Grecja (rok: 2017, ), Wydawca: HELLENIC NEUROLOGICAL SOCIETY, Athens, Greece
    Data:
    konferencja Marzec 23-26
    Status:
    Published
  2. Differential involvement of adenosine receptors in rodent models of parkinsonian and essential tremors
    Authors:
    Kosmowska B., Zelek-Molik A., Lenda T., Głowacka U., Ossowska K., Wardas J.
    Conference:
    DOPAMINE 2016 (rok: 2016, ), Wydawca: Intrinsic Activity, published by Austrian Pharmacological Society (APHAR)
    Data:
    konferencja 5 - 8.09 Wiedeń, Austria
    Status:
    Published
  3. Pramipexole at a low dose induces beneficial effects in the harmaline-induced model of essential tremor in rats
    Authors:
    Kosmowska B, Wardas J, Glowacka U, Ananthan S
    Conference:
    12th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology Polish Neuroscience Society, Warszawa Polska
    Data:
    konferencja 6-8 września 2015
    Status:
    Published
  4. The Involvement Of Dopamine Receptors In The Regulation Of Harmaline‐Induced Tremor Measured By Force Plate Actimeters
    Authors:
    Kosmowska B, Glowacka U, Wardas J, Ossowska K
    Conference:
    MDS 19th International Congress of Parkinson's Disease and Movement Disorders (rok: 2015, ), Wydawca: Wiley Online Library - John Wiley & Sons Ltd
    Data:
    konferencja 14-18 czerwca 2015
    Status:
    Published
    DOI:
    link to the publication
  5. Role of adenosine A1 and A2A receptors in rodent models of parkinsonian and essential tremors.
    Authors:
    Kosmowska B., Zelek-Molik A., Lenda T., Głowacka U., Ossowska K., Wardas J.
    Conference:
    2nd CENTRAL EUROPEAN BIOMEDICAL CONGRESS, (rok: 2016, ), Wydawca: Abstract Book
    Data:
    konferencja 15-18.06.2016 Kraków
    Status:
    Published
  6. 5'-chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A1 receptor agonist, inhibits harmaline-induced tremor in rats by reducing the release of glutamate in ventral motor thalamic nuclei
    Authors:
    Barbara Kosmowska, Jolanta Konieczny, Tomasz Lenda, Klemencja Berghauzen-Maciejewska, Krystyna Ossowska, Jadwiga Wardas
    Conference:
    11th FENS Forum of Neuroscience 2018 (rok: 2018, ), Wydawca: FENS, Forum of European Neuroscience Societies
    Data:
    konferencja 7-11 czerwiec, 2018
    Status:
    Published
    DOI:
    link to the publication

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