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The role of nitric oxide-dependent pathways in the procognitive effects of muscarinic and metabotropic glutamate receptors activators.

2019/33/B/NZ7/02699

Keywords:

muscarinic receptors metabotropic glutamate receptors schizophrenia dementia nitric oxide

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Monika Wierońska 

Number of co-investigators in the project: 7

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 838 200 PLN

Project start date (Y-m-d): 2020-01-29

Project end date (Y-m-d): 2025-01-28

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets.
    Authors:
    Janaszak-Jasiecka A, Płoska A, Wierońska JM, Dobrucki LW, Kalinowski L.
    Academic press:
    Cell Mol Biol Lett (rok: 2023, tom: 28(1), strony: 21), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s11658-023-00423-2 - link to the publication
  2. Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
    Authors:
    Wierońska JM, Cieślik P, Kalinowski L
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1097-1126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11081097 - link to the publication
  3. Procognitive activity of nitric oxide inhibitors and donors in animal models.
    Authors:
    Paulina Cieślik, Leszek Kalinowski, Joanna M Wierońska
    Academic press:
    Nitric Oxide (rok: 2022, tom: 119, strony: 29-40), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.niox.2021.12.003 - link to the publication
  4. Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis.
    Authors:
    Wierońska JM, Cieślik P, Burnat G, Kalinowski L
    Academic press:
    Biomolecules (rok: 2023, tom: 13 (7), strony: 1064), Wydawca: MDPI
    Status:
    Published
    DOI:
    2218-273X/13/7/1064 - link to the publication
  5. Neurochemical changes underlying cognitive impairment in olfactory bulbectomized rats and the impact of the mGlu5-positive allosteric modulator CDPPB.
    Authors:
    Płoska A, Cieślik P, Siekierzycka A, Kalinowski L, Wierońska JM.
    Academic press:
    Brain Res (rok: 2021, tom: 1768, strony: 147577), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainres.2021.147577 - link to the publication
  6. Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
    Authors:
    Wierońska JM, Cieślik P, Kalinowski L
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1097-1126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11081097 - link to the publication
  7. Nitric Oxide-Dependent Mechanisms Underlying MK-801- or Scopolamine-Induced Memory Dysfunction in Animals: Mechanistic Studies.
    Authors:
    Cieślik P, Siekierzycka A, Radulska A, Płoska A, Burnat G, Brański P, Kalinowski L, Wierońska JM.
    Academic press:
    Int J Mol Sci (rok: 2021, tom: 22, strony: 12282), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222212282 - link to the publication
  8. Prevention of MK-801-induced amnestic effect with combined activation of 5-HT1A and muscarinic receptors in mice.
    Authors:
    Cieślik P, Rafało-Ulińska A, Wierońska JM
    Academic press:
    Pharmacology Biochemistry and Behaviour (rok: 2024, tom: 238, strony: 173749), Wydawca: Elsevier
    Status:
    Published
    DOI:
    article/pii/S0091305724000431?via%3Dihub - link to the publication
  9. Procognitive activity of nitric oxide inhibitors and donors in animal models.
    Authors:
    Paulina Cieślik, Leszek Kalinowski, Joanna M Wierońska
    Academic press:
    Nitric Oxide (rok: 2022, tom: 119, strony: 29-40), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.niox.2021.12.003 - link to the publication
  10. A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze
    Authors:
    Paulina Cieślik, Magdalena Borska, Joanna M Wieronska
    Academic press:
    Brain Sciences (rok: 2023, tom: 13, strony: 410), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci13030410 - link to the publication
  11. The Impact of LY487379 or CDPPB on eNOS Expression in the Mouse Brain and the Effect of Joint Administration of Compounds with NO• Releasers on MK-801- or Scopolamine-Driven Cognitive Dysfunction in Mice
    Authors:
    Płoska A, Siekierzycka A, Cieślik P, Dobrucki LW, Kalinowski L, Wierońska JM
    Academic press:
    Molecules (rok: 2024, tom: 29(3), strony: 627), Wydawca: MDPI
    Status:
    Published
    DOI:
    1420-3049/29/3/627 - link to the publication

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