Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Study of SNAP-25 protein expression, NMR metabolomic analysis and behavioral characteristics in animal models of infantile autism: reference to glutamate hypothesis

2014/15/B/NZ4/04490

Keywords:

animal models autism biomarkers glutamatergic neurotransmission metabolomics NMR spectroscopy SNARE proteins,

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_4: Pathophysiology
  • NZ2_4: Metabolomics

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Łazarewicz 

Number of co-investigators in the project: 7

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 913 192 PLN

Project start date (Y-m-d): 2015-07-09

Project end date (Y-m-d): 2019-07-08

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Licencja jednostanowiskowa na program SIMCA P+ (20 000 PLN)
  2. Pompa próżniowa z wyposażeniem (7 000 PLN)
  3. Zestaw komputerowy z wyposażeniem i oprogramowaniem do wstępnej analizy danych (2 szt.) (10 000 PLN)
  4. Aparatura do rejestracji i analizy ultradźwięków (32 000 PLN)
  5. Licencja jednostanowiskowa na program Borland Delphi/C# (6 000 PLN)
  6. Termocykler do analiz w czasie rzeczywistym z wyposażeniem (100 000 PLN)
  7. Worteks MSV-3500.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (7)
  1. Glutamate, Glutamine and GABA Levels in Rat Brain Measured Using MRS, HPLC and NMR Methods in Study of Two Models of Autism.
    Authors:
    Zieminska E, Toczylowska B, Diamandakis D, Hilgier W, Filipkowski RK, Polowy R, Orzel J, Gorka M and Lazarewicz JW
    Academic press:
    Front. Mol. Neurosci. (rok: 2018, tom: 11, strony: 418), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fnmol.2018.00418 - link to the publication
  2. Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells
    Authors:
    Zieminska E, Lenart J, Lazarewicz JW.
    Academic press:
    Toxicology (rok: 2016, tom: 370, strony: 86-93), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.tox.2016.09.013. - link to the publication
  3. Changes in the expression of genes in the brain involved in synaptic vesicle trafficking in juvenile male rats in two models of autism
    Authors:
    Jacek Lenart, Ewelina Bratek, Jerzy W. Łazarewicz, Elżbieta Ziemińska
    Academic press:
    Journal of Molecular Neuroscience (rok: 2020, tom: 70, strony: 1313-1320), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12031-020-01543-6 - link to the publication
  4. Altered expression of glutamatergic and GABAergic genes in the valproic acid-induced rat model of autism: a screening test
    Authors:
    Jacek Lenart, Justyna Augustyniak, Jerzy W. Łazarewicz, Elżbieta Ziemińska
    Academic press:
    Toxicology (rok: 2020, tom: 440, strony: 152500), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2020.152500 - link to the publication
  5. Zinc and copper brain levels and expression of neurotransmitter receptors in two rat ASD models
    Authors:
    Elżbieta Ziemińska, Anna Ruszczyńska, Justyna Augustyniak, Beata Toczyłowska, Jerzy W. Łazarewicz
    Academic press:
    Frontiers in Molecular Neuroscience , Wydawca: Frontiers Media SA
    Status:
    Submitted
    DOI:
    Brak - link to the publication
  6. Hippocampal metabolite profiles in two rat models of autism: NMR-based metabolomics studies
    Authors:
    B. Toczyłowska, E. Zieminska, P. Senator, J.W. Łazarewicz
    Academic press:
    Molecular Neurobiology (rok: 2020, tom: 57, strony: 3089-3105), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-020-01935-0 - link to the publication
  1. Glutamate, Glutamine and GABA levels in the rat hippocampus in the pharmacological models of autism: a microdialysis study
    Authors:
    Dominik Diamandakis, Elżbieta Ziemińska, Wojciech Hilgier, Robert K. Filipkowski, Rafał Polowy, Beata Toczyłowska, Jerzy W. Łazarewicz
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis, 77 (Sup. 1), IBD im. Nenckiego PAN
    Data:
    konferencja 26-31 August 2017
    Status:
    Published
  2. Glutamate, glutamine and GABA levels in the rat hippocampus in the pharmacological models of autism: MRS and NMR study
    Authors:
    Elżbieta Ziemińska, Robert K. Filipkowski, Rafał Polowy, Jarosław Orzeł, Beata Toczyłowska, Michał J. Górka, Jerzy W. Łazarewicz
    Conference:
    13th International Congress of Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiologiae Experimentalis, 77 (Sup. 1), IBD im. Nenckiego PAN
    Data:
    konferencja 26-31 August 2017
    Status:
    Published
  3. Comparison of two animal models of autism using 13C NMR spectroscopy of rat urine hydrophilic compounds
    Authors:
    P. Senator, B. Toczyłowska, E. Ziemińska, J.W. Łazarewicz
    Conference:
    XXI Polish Conference on Biocybernetics and Biomedical Engineering (rok: 2019, ), Wydawca: PCBBE
    Data:
    konferencja 25-27.08.2019
    Status:
    Published
  4. Glutamate, glutamine and GABA levels in the rat hippocampus in two models of autism measured by MRS, NMR and HPLC methods
    Authors:
    D. Diamandakis, E. Zieminska, W. Hilgier, J. Orzel, B. Toczylowska and J.W. Lazarewicz
    Conference:
    22nd Biennale Meeting of the International Society for Developmental Neuroscience ISDN2018 (rok: 2018, ), Wydawca: Program Booklet ISDN and ELSEVIER
    Data:
    konferencja 22 – 22 May 2018
    Status:
    Published
  5. SNAP-25: potential link between genetic and environmental causes of autism.
    Authors:
    Ziemińska E., Lenatr J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders", Warsaw Poland. (rok: 2016, ), Wydawca: Folia Neuropathologica, 54(3), wydawca: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  6. Total Glu, Gln and GABA content in the hippocampus in two rat models of autism: in vivo and ex vivo magnetic resonance study
    Authors:
    Elzbieta Zieminska, Robert Filipkowski, Rafal Polowy, Jaroslaw Orzel, Beata Toczylowska, Michal Gorka, Jerzy W. Lazarewicz
    Conference:
    Neurochemical Conference 2017: Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (rok: 2017, ), Wydawca: Folia Neuropathologica 55 (3), wydawca: Termedia
    Data:
    konferencja October 19-20, 2017
    Status:
    Published
  7. Measurements of rat hippocampus Glu, Gln and GABA using NMR, MRS and HPLC in animal models of autism
    Authors:
    Pawel Senator, Elzbieta Zieminska, Wojciech Hilgier, Jaroslaw Orzel, and Beata Toczylowska
    Conference:
    Joint Annual Meeting ISMRM-ESMRMB (rok: 2018, ), Wydawca: Proc. Intl. Soc. Mag. Reson. Med.
    Data:
    konferencja 16-21 June, 2018
    Status:
    Published

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