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Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate release (mGlu2, mGlu4 or GABAB) as the new target in the search for effective antipsychotic drugs.The role of special drug combinations in the context of positive, negative and cognitive symptoms of schizophrenia.

2015/17/B/NZ7/02984

Keywords:

schizophrenia mGlu2 mGlu4 GABAB muscarinic M4

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Wierońska 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 629 400 PLN

Project start date (Y-m-d): 2016-02-15

Project end date (Y-m-d): 2020-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (3)
  1. Negative Allosteric Modulators of mGlu7 Receptor as Putative Antipsychotic Drugs.
    Authors:
    Cieślik P, Woźniak M, Kaczorowska K, Brański P, Burnat G, Chocyk A, Bobula B, Gruca P, Litwa E, Pałucha-Poniewiera A, Wąsik A, Pilc A, Wierońska J.
    Academic press:
    Front Mol Neurosci (rok: 2018, tom: 11, strony: 316), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2018.00316 - link to the publication
  2. Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychotic.
    Authors:
    Cieślik P, Woźniak M, Tokarski K, Kusek M, Pilc A, Płoska A, Radulska A, Pelikant-Małecka I, Żołnowska B, Sławiński J, Kalinowski L, Wierońska JM.
    Academic press:
    Behavioral Brain Research (rok: 2019, tom: 359, strony: 671-685), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2018.09.01 - link to the publication
  3. Simultaneous activation of mGlu2 and muscarinic receptors reverses MK-801-induced cognitive decline in rodents
    Authors:
    Paulina Cieślik, Helena Domin, Agnieszka Chocyk, Piotr Gruca, Ewa Litwa, Agata Płoska, Adrianna Radulska, Iwona Pelikant-Małecka, Piotr Brański, Leszek Kalinowski, Joanna M Wierońska
    Academic press:
    Neuropharmacology (rok: 2019, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2019.107866 - link to the publication
  4. Depression and schizophrenia viewed from the perspective of amino acidergic neurotransmission: Antipodes of psychiatric disorders.
    Authors:
    Wierońska JM, Pilc A.
    Academic press:
    Pharmacol Ther (rok: 2019, tom: 193, strony: 75-82), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharmthera.2018.08.010 - link to the publication
  5. Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents.
    Authors:
    Cieślik P, Woźniak M, Rook JM, Tantawy MN, Conn PJ, Acher F, Tokarski K, Kusek M, Pilc A, Wierońska JM.
    Academic press:
    Psychoparmacology (rok: 2018, tom: 235, strony: 2897-2913), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-018-4980-y - link to the publication
  6. Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice.
    Authors:
    Woźniak M, Cieślik P, Marciniak M, Lenda T, Pilc A, Wieronska JM.
    Academic press:
    Pharmacol Biochem Behav. (rok: 2018, tom: 172, strony: 50-58), Wydawca: Eksevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2018.06.003 - link to the publication
  7. Reversal of MK-801-induced disruptions in social behavior and working memory with LY487379 and VU152100 administered simultaneously in mice.
    Authors:
    Paulina Cieślika, Adrianna Radulska, Iwona Pelikant-Małecka, Agata Płoska, Leszek Kalinowski, Joanna M Wierońska
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(11), strony: brak), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20112781 - link to the publication
  1. Antipsychotic-like action of combined administration of mGlu4 receptor activators.
    Authors:
    Wierońska JM, Woźniak M, Cieślik P, Acher F, Pilc A
    Conference:
    Australasian Neuroscience Society 36th Annual Scientific Meeting (rok: 2016, ), Wydawca: ANS
    Data:
    konferencja 4-8 December
    Status:
    Published
  2. THE INFLUENCE OF POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC AND MGLU4 RECEPTORS ON DOPAMINERGIC DYSFUNCTION IN THE RAT BRAIN. IMPLICATION TO ANTIPSYCHOTIC EFFICACY
    Authors:
    Wierońska Joanna M., Cieślik Paulina, Acher Francine, Conn Peter J., Michelle Jerri R., Tantawy Mohammad N., Pilc Andrzej
    Conference:
    European Behavioral Pharmacological Society (rok: 2017, ), Wydawca: EBPS
    Data:
    konferencja 31.08-3.09. 2017
    Status:
    Published
  3. The antipsychotic-like activity of VU152100, a muscarinic M4 receptor positive allosteric modulator, in animal models of schizophrenia.
    Authors:
    Wieronska JM, Wozniak M, Cieślik P, Pilc A
    Conference:
    29th ECNP Congress, , Vienna, Austria (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 17-20 September
    Status:
    Published

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