Searching for molecular basis of addiction-prone phenotype - a role of astrocyte biomarkers (xc-, EAAT2) and metabotropic glutamate receptors mGluR1, mGluR5 and mGluR2/3 in the mechanism of vulnerabiility to addiction.
2013/11/N/NZ7/01617
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_2: Zagrożenia środowiskowe
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny
Voivodeship: małopolskie
Principal investigator (from the host institution)
Ewa Magdalena Niedzielska-Andres
Number of co-investigators in the project: 2
Call
PRELUDIUM 6 – announced on 2013-09-16
- Amount awarded
- 149 240 PLN
- Project start date
- 2014-08-27
- Project end date
- 2017-11-26
- Project duration
- 39 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (1)
-
Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone
- Authors:
- Ewa Niedzielska-Andres, Józef Mizera, Anna Sadakierska-Chudy, Lucyna Pomierny-Chamioło, Małgorzata Filip
- Status:
- Accepted for publication
Articles in post-conference publications (3)
-
Ceftriaxone as an anti - relapse drug for cocaine use disorder – preclinical evaluation
- Authors:
- Niedzielska - Andres E, Pomierny - Chamioło L, Filip M
- Conference:
- 2nd Central European Biomedical Congress (year: 2016, pages: 79), Publisher: IF PAN
- Date:
- conference 15-18.06.2016
- Status:
- Published
- DOI:
- link to the publication
-
Could antibiotics cure the addiction? Preclinical evaluation of efficacy of an antibiotic-ceftriaxone in cocaine addiction treatment
- Authors:
- Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Maria Walczak, Małgorzata Filip
- Conference:
- Aspects of Neuroscience (year: 2017, pages: 54-55), Publisher: Aspects of Neuroscience
- Date:
- conference 24-26.11
- Status:
- Published
-
DIFFERENCES IN BRAIN GLUTAMATE MGLUR2/3, MGLUR1 AND MGLUR5 RECEPTORS EXPRESSION AFTER COCAINE ADMINISTRATION IN RATS SHOWING ADDICTION-VULNERABLE OR ADDICTION-RESISTANT PHENOTYPE.
- Authors:
- Niedzielska-Andres E, Filip M, Pomierny-Chamiolo L
- Conference:
- FENS-SFN SUMMER SCHOOL 2016 CELLULAR MECHANISMS AND NETWORKS IN ADDICTION (year: 2016, pages: 35-36), Publisher: FENS - Federation of European Neuroscience Societies, SFN- Society for Neuroscience
- Date:
- conference 29 maj – 4 czerwiec
- Status:
- Published