Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Role of astrocytic NMDA receptors in ammonia-induced brain edema associated with hepatic encephalopathy.

2013/08/M/NZ3/00869

Keywords:

astrocyte ammonia NMDA receptor edema cytokines oxidative-nitrosative stress,glutamate potassium fluxes

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_2: Cell physiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Albrecht 

Number of co-investigators in the project: 7

Call: HARMONIA 4 - announced on 2012-12-15

Amount awarded: 935 000 PLN

Project start date (Y-m-d): 2013-08-29

Project end date (Y-m-d): 2017-02-28

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Book publications / chapters in book publications (1)
  1. Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure
    Authors:
    Marta Obara-Michlewska, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky,Maiken Nedergaard, Magdalena Zielinska, Jan Albrecht
    Academic press:
    Neurochemistry International (rok: 2018, tom: 118, strony: 286-291), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2018.05.007 - link to the publication
  2. NMDA Receptors in Astrocytes: In Search for Roles in Neurotransmission and Astrocytic Homeostasis.
    Authors:
    Katarzyna Skowrońska, Marta Obara-Michlewska, Magdalena Zielińska, Jan Albrecht
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 309), Wydawca: MDPI (Basel)
    Status:
    Published
    DOI:
    10.3390/ijms20020309 - link to the publication
  3. Persistentoverexposure to N-methyl-D-aspartate (NMDA) calcium-dependentlydownregulatesglutaminesynthetase, aquaporin 4 and Kir4.1 channel in mousecorticalastrocytes.
    Authors:
    Katarzyna Skowrońska, Marta Obara-Michlewska, Anna Czarnecka, Katarzyna Dąbrowska, Magdalena Zielińska, and Jan Albrecht
    Academic press:
    Neurotoxicity Research (rok: 2019, tom: 35, strony: 271–280), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-018-9958-3 - link to the publication
  4. Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure.
    Authors:
    Marta Obara-Michlewska, Joanna Ruszkiewicz, Magdalena Zielińska, Alexei Verkhratsky, Jan Albrecht
    Academic press:
    Neurochemistry International (rok: 2014, tom: xxx, strony: xxx), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.006 - link to the publication
  1. Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission
    Authors:
    Verkhratsky A. Parpura V
    Book:
    COLLOQUIUM SERIES ON NEUROGLIA IN BIOLOGY AND MEDICINE: FROM PHYSIOLOGY TO DISEASE (rok: 2015, tom: vol 1, strony: 1-155), Wydawca: Morgan & Claypool
    Status:
    Published

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