Projects funded by the NCN
New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychiatric diseases
2022/45/B/NZ7/00598
Keywords:
EAAT2 transporter positive allosteric modulators (PAMs) synthesis in vivo studies in vitro studies anti-seizure activity neuroprotective activity
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
prof. Krzysztof Tomasz Kamiński
Number of co-investigators in the project: 20
Call: OPUS 23 - announced on 2022-03-28
Amount awarded: 2 884 054 PLN
Project start date (Y-m-d): 2023-02-07
Project end date (Y-m-d): 2027-02-06
Project duration:: 48 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of ConceptAuthors:Krzysztof Kamiński, Katarzyna Socała, Michał Abram, Marcin Jakubiec, Katelyn L. Reeb, Rhea Temmermand, Mirosław Zagaja, Maciej Maj, Magdalena Kolasa, Agata Faron-Górecka, Marta Andres-Mach, Aleksandra Szewczyk, Mustafa Q. Hameed, Andréia C. K. Fontana, Alexander Rotenberg, Rafał M. KamińskiAcademic press:Annals of Neurology (rok: 2025, tom: 97, strony: 344–357), Wydawca: Wiley Periodicals LLCStatus:PublishedDOI:10.1002/ana.27124 - link to the publication