Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacological properties and neurotoxicity of novel NBOMe derivatives

2016/21/B/NZ7/01131

Keywords:

dopamine serotonin glutamate acetylocholine in vivo microdialysis NBOMe neurotoxicity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krystyna Gołembiowska 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 480 370 PLN

Project start date (Y-m-d): 2017-01-27

Project end date (Y-m-d): 2021-01-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stolik sterotaktyczny z pojedynczym manipulatorem dla szczura (18 000 PLN)
  2. Komputer (3 000 PLN)
  3. System Alexis Antec (478 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (6)
  1. Hallucinogen-Like Action of the Novel Designer Drug 25I-NBOMe and Its Effect on Cortical Neurotransmitters in Rats
    Authors:
    Monika Herian, Adam Wojtas, Katarzyna Kamińska, Paweł Świt, Anna Wach, Krystyna Gołembiowska
    Academic press:
    Neurotoxicity Rsearch (rok: 2019, tom: 36, strony: 91-100), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-019-00033-x - link to the publication
  2. Tolerance to neurochemical and behavioral efects of the hallucinogen 25I‑NBOMe
    Authors:
    Monika Herian, Mateusz Skawski, Adam Wojtas, Małgorzata K. Sobocińska, Karolina Noworyta, Krystyna Gołembiowska
    Academic press:
    Psychopharmacology (rok: 2021, tom: 238, strony: 2349-2364), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00213-021-05860-5 - link to the publication
  3. Neurochemical and Behavioral Efects of a New Hallucinogenic Compound 25B‑NBOMe in Rats
    Authors:
    Adam Wojtas, Monika Herian, Mateusz Skawski, Małgorzata Sobocińska, Alejandro Gonzalez-Marin, Karolina Noworyta-Sokołowska, Krystyna Gołembiowska
    Academic press:
    Neurotoxicity Research (rok: 2021, tom: 39, strony: 305-326), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-020-00297-8 - link to the publication
  4. Hallucinogenic Activity, Neurotransmitters Release, Anxiolytic and Neurotoxic Effects in Rat's Brain Following Repeated Administration of Novel Psychoactive Compound 25BNBOMe.
    Authors:
    Adam Wojtas, Monika Herian, Marzena Maćkowiak, Anna Solarz, Agnieszka Wawrzczak-Bargiela, Agnieszka Bysiek, Karolina Noworyta, Krystyna Gołembiowska
    Academic press:
    Neuropharmacology (rok: 2022, ), Wydawca: Elsevier
    Status:
    Submitted
  5. Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission
    Authors:
    Monika Herian, Adam Wojtas, Małgorzata Katarzyna Sobocińska, Mateusz Skawski, Alejandro Gonzalez-Marin, Krystyna Gołembiowska
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 1593-1603), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00181-4 - link to the publication
  6. Neurotoxicological profle of the hallucinogenic compound 25I‑NBOMe
    Authors:
    Monika Herian, Adam Wojtas, Marzena Maćkowiak, Agnieszka Wawrzczak-Bargiela, Anna Solarz, Agnieszka Bysiek, Katarzyna Madej, Krystyna Gołembiowska
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 2939), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-022-07069-8 - link to the publication
  1. Acetylcholine determination in biological samples – new aspects of analytical calibration"
    Authors:
    Paweł Świt, Katarzyna Kamińska, Monika Herian, Adam Wojtas, Krystyna Gołembiowska
    Conference:
    3rd Central European Biomedical Congress 'News on biomarker discovery and research innovations in medicine and biomedical sciences (rok: 2018, ), Wydawca: CEBC Kraków
    Data:
    konferencja 15-18 September
    Status:
    Published
  2. Similarities and differences in neuropharmacology of two compounds representing indoleamine and N-benzylphenethylamine (NBOMe) hallucinogens.
    Authors:
    Gołembiowska K.
    Conference:
    Sinapsa Neuroscience Conference 2019, 20-21 Sept., 2019 Ljubliana, Slovenia. (rok: 2019, ), Wydawca: Sinapsa Neurosceince Conference
    Data:
    konferencja 43728
    Status:
    Published
  3. Pharmacological properties of the hallucinogenic compound 25B-NBOMe.
    Authors:
    Herian M., Świt P., Kamińska K., Wojtas A., Gołembiowska K.
    Conference:
    7th Conference of the Mediterranean Neuroscience Society (MNS) Atlas Medina @ Spa (rok: 2019, ), Wydawca: Mediterranean Neuroscience Society (MNS)
    Data:
    konferencja 23-27 June
    Status:
    Published
  4. The effect of 25-I-NBOMe on rat brain neurotransmission
    Authors:
    Kamińska Katarzyna, Wojtas Adam, Herian Monika, Świt Paweł, Gołembiowska Krystyna
    Conference:
    3rd Central European Biomedical Congress 'News on biomarker discovery and research innovations in medicine and biomedical sciences (rok: 2018, ), Wydawca: CEBC, Kraków 2018
    Data:
    konferencja 15-18 September
    Status:
    Published
  5. Effect of 4-iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine on brain neurotransmitters and rats' locomotor activity.
    Authors:
    Herian M., Kamińska K., Świt P., Skawski M., Wojtas A., Sobocińska M., Gołembiowska K.
    Conference:
    ECNP Workshop on Early Career Scientists in Europe (rok: 2020, ), Wydawca: Eur. Neuropsychopharmacol.
    Data:
    konferencja 12-15 September
    Status:
    Published
  6. The effect of 25-I-NBOMe on rat's brain neurotransmitters and motor activity
    Authors:
    Adam Wojtas, Katarzyna Kamińska, Monika Herian, Paweł Świt, Krystyna Gołembiowska
    Conference:
    3rd Central European Biomedical Congress 'News on biomarker discovery and research innovations in medicine and biomedical sciences (rok: 2018, ), Wydawca: CEBC Kraków
    Data:
    konferencja 15-18 September
    Status:
    Published

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