Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Role of glutamine synthesis in the initial phase of temporal lobe epilepsy in the juvenile rat lithium-pilocarpine model: mechanism of activation of glutamine synthetase

2016/23/B/NZ4/03678

Keywords:

temporal lobe epilepsy glutamate glutamine astrocyte neuron

Descriptors:

  • NZ4_7:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Albrecht 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 089 200 PLN

Project start date (Y-m-d): 2017-07-27

Project end date (Y-m-d): 2022-07-26

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of the extracellular taurine in the hippocampus
    Authors:
    Marek Pawlik, Anna Maria Czarnecka, Marcin Kołodziej, Katarzyna Skowrońska, Michał Węgrzynowicz, Martyna Podgajna, Stanisław Jerzy Czuczwar, Jan Albrecht
    Academic press:
    Epilepsia (rok: 2023, tom: unknown, "accepted article" status, strony: first published: 17.03.2023), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/epi.17554 - link to the publication
  2. Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose
    Authors:
    Pawlik, M.J.; Aldana, B.I.; Belfiori-Carrasco, L.F.; Obara-Michlewska, M.; Popek, M.P.; Czarnecka, A.M.; Albrecht, J.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22, strony: 11127), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011127 - link to the publication
  3. Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats
    Authors:
    Marek J. Pawlik, Marta Obara-Michlewska, Mariusz P. Popek, Anna Maria Czarnecka, Stanisław J. Czuczwar, Jarogniew Łuszczki, Marcin Kołodziej, Albert Acewicz, Teresa Wierzba-Bobrowicz, Jan Albrecht
    Academic press:
    Brain Research (rok: 2021, tom: 1753, strony: 147253), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainres.2020.147253253 - link to the publication
  4. Selected Molecular Targets for Antiepileptogenesis
    Authors:
    Marek J. Pawlik, Barbara Miziak, Aleksandra Walczak, Agnieszka Konarzewska, Magdalena Chrościńska-Krawczyk, Jan Albrecht , Stanisław J. Czuczwar
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(18), strony: 9737), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189737 - link to the publication
  1. Rapid MSO-sensitive extracellular accumulation of taurine in hippocampus of young rats during initial pilocarpine-induced seizures
    Authors:
    Marek Pawlik, Anna Maria Czarnecka, Katarzyna Skowrońska, Marcin Kołodziej, Krystyna Gołembiowska, Jan Albrecht
    Conference:
    ISN-APSN 2022 Meeting (rok: 2022, ), Wydawca: Wiley
    Data:
    konferencja 44801
    Status:
    Published
  2. Pretreatment with MSO attenuates behavioral but not electrographic seizures elicited by pilocarpine in juvenile rats
    Authors:
    M. Pawlik, M. Obara-Michlewska, S. J. Czuczwar, J. Łuszczki, A. Acewicz, T. Wierzba-Bobrowicz, M. Kołodziej, M. Popek, J. Albrecht
    Conference:
    ISN-ASN 2019 Meeting (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 43681
    Status:
    Published
  3. Dysregulated astrocytic glutamine transport in acute hyperammonemic brain edema
    Authors:
    Mariusz Popek, Jan Albrecht, Magdalena Zielińska
    Conference:
    2022 Cold Spring Harbor meeting: Glia in Health & Disease (rok: 2022, ), Wydawca: Cold Spring Harbor laboratory
    Data:
    konferencja 21-25 lipiec
    Status:
    Published

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