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Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

2020/39/B/NZ7/00558

Keywords:

Quinoxalino-2,3-diones glutamate ionotropic receptors kainate receptors AMPA receptors competitive anatgonists anticonvulsant agents homology modeling

Descriptors:

  • NZ7_014:
  • ST4_008:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Collegium Medicum

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Monika Szymańska 

Number of co-investigators in the project: 11

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 1 479 520 PLN

Project start date (Y-m-d): 2021-07-15

Project end date (Y-m-d): 2026-07-14

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
    Authors:
    Chałupnik, P.; Vialko, A.; Pickering, D.S.; Hinkkanen, M.; Donbosco, S.; Møller, T.C.; Jensen, A.A.; Nielsen, B.; Bay, Y.; Kristensen, A.S.; Johansen, T.N.; Łątka, K.; Bajda. M.; Szymańska, E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 8797), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158797 - link to the publication
  2. Structure-Activity Relationship and Solubility Studies of N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists
    Authors:
    Chałupnik, P.; Vialko, A.; Pickering, D.S.; Nielsen, B.; Bay, Y.; Kristensen, A.S.; Hinkkanen, M.; Szczepańska, K.; Karcz, T.; Latacz, G.; Johansen, T.N.; Szymańska, E.
    Academic press:
    ChemMedChem (rok: 2023, tom: 18, strony: e202300278), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/cmdc.202300278 - link to the publication
  3. Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective
    Authors:
    Chałupnik, P.; Szymańska, E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 1908), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24031908 - link to the publication
  4. Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype
    Authors:
    Chałupnik, P.; Vialko, A.; Pickering, D.S.; Hinkkanen, M.; Donbosco, S.; Møller, T.C.; Jensen, A.A.; Nielsen, B.; Bay, Y.; Kristensen, A.S.; Johansen, T.N.; Łątka, K.; Bajda. M.; Szymańska, E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 8797), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158797 - link to the publication

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