Projects funded by the NCN

Selected antidepressants toxicity assessment based on in vitro studies of rat spermatocytes and mouse cell lines.

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Przemysław Paweł Sołek

Uniwersytet Rzeszowski, Wydział Biotechnologii

Evaluation of anticancer properties of thiosugars

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Joanna Katarzyna Sarnik

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Role of the selected anti-tumor agents transported by electropermeabilization to the drug-sensitive and drug-resistant c...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: dr Joanna Barbara Weżgowiec

Politechnika Wrocławska, Wydział Podstawowych Problemów Techniki

The influence of whole body cryotherapy on the level of certain cytokines, oxidative stress indicators and carbohydrate ...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: dr Justyna Maria Sproull

AKADEMIA WYCHOWANIA FIZYCZNEGO IM. BRONISŁAWA CZECHA W KRAKOWIE, Wydział Wychowania Fizycznego i Sportu

The study of synergistic inhibition of tumor cell proliferation by CK2 casein kinase inhibitors and inhibitors of thymid...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Pharmacokinetics and organ distribution of treosulfan and its biologically active epoxy-transformers in rats

Call: SONATA 7 , Panel: NZ7

Principal investigator: dr Michał Romański

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Effect of parabens and their mixtures on selected parameters related to the development of breast cancer in models og ho...

Call: PRELUDIUM 1 , Panel: NZ7

Principal investigator: Anna Maria Wróbel

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi; Instytut Zoologii

Search for the mechanisms of the modulation of canonical Wnt signaling which effectively attenuate the survival of head ...

Call: SONATA 7 , Panel: NZ7

Principal investigator: dr Jarosław Jan Paluszczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Synthesis and biological examination new functionalized of acridine/acridone derivatived as potential anticancer compoun...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Krystyna Jolanta Dzierzbicka

Politechnika Gdańska, Wydział Chemiczny

Search for novel mechanisms underlining inhibition of cancer cell proliferation by plant-derived nutraceuticals

Call: SONATA 6 , Panel: NZ7

Principal investigator: dr hab. Anna Lewińska

Uniwersytet Rzeszowski

Searching for natural substances with antitubercular activity and their influence on the cell wall synthesis process in ...

Call: SONATA 6 , Panel: NZ7

Principal investigator: dr Elwira Zofia Sieniawska

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Risk factors for subependymal giant cell astrocytoma in tuberous sclerosis complex.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Julita Borkowska

INSTYTUT - POMNIK - CENTRUM ZDROWIA DZIECKA

Study of the effect of naphthoflavone structure on aromatase inhibition and cytotoxicity against normal and cancer cell ...

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Jarosław Tomasz Popłoński

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Nauk o Żywności

Proapoptotic activity of dried leaf blade aqueouos extract from Vilcacora (Uncaria tomentosa) in selected cancer cell li...

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: Anita Halina Kośmider

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Effects of ethylene glycol ethers on oxidative stress and key enzymes of glucose metabolism in some regions of the brain...

Call: OPUS 1 , Panel: NZ7

Principal investigator: prof. Bogusława Budziszewska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Evaluation of peroxiredoxins 1 and 2 along with the thioredoxin-thioredoxin reductase system as new therapeutic targets ...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Chemopreventive properties of polysaccharides isolated from edible Basidiomycete mushroom (Boletus edulis). In vitro and...

Call: HARMONIA 1 , Panel: NZ7

Principal investigator: prof. Wojciech Rzeski

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

The role of cell wall polysaccharides isolated from probiotic Lactobacilus casei and Lactobacillus paracasei strains in ...

Call: SONATA 3 , Panel: NZ7

Principal investigator: dr Sabina Barbara Górska

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Combination therapy with naphthoquinones and paclitaxel in the pharmacological induction of cell death in breast cancer ...

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr Anna Kawiak

Uniwersytet Gdański

Defining The Role of Microbiome Mimicry in Type 1 Diabetes (T1D): a pilot study for Single-Cell Strain-characterisation ...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr Marcin Lukasz Pekalski

Wojskowy Instytut Medyczny

Canonical and non-canonical roles of DDK in oncogenesis: a cornerstone for the development of novel, potent anticancer t...

Call: SONATA BIS 14 , Panel: NZ3

Principal investigator: dr Jan Marian Suski

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Biological activity of AmB: Are the dynamics of interaction with the cell membrane the key?

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Sebastian Janik

Uniwersytet Marii Curie-Skłodowskiej w Lublinie

Restoring Endothelial Cell Mechanostimulation by Shear Stress in Chronic Wounds Models Using Glycocalyx-Mimicking Nanopa...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Mateusz Krzysztof Wierzbicki

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Evaluation of the relationship between doxorubicin resistance, epithelial-mesenchymal plasticity, and effects of selecte...

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Dominika Kunachowicz

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej

Platelet-derived growth factor (PDGF-BB) and its peptide derivative as factors increasing cell activity for use in diabe...

Call: SONATA 19 , Panel: NZ3

Principal investigator: dr Milena Deptuła

Gdański Uniwersytet Medyczny, Wydział Lekarski

Is metformin having a cardioprotective role in mouse model of autoimmune myocarditis. Evaluation of the mechanism of act...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Monika Marta Stefańska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

Call: OPUS 26 (LAP) , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

The Impact of Undernutrition on Host Microbiome: the Messenger Role of Bacterial Extracellular Vesicles.

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Agnieszka Maria Razim

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

A new generation of scaffolds based on curdlan and whey protein isolate obtained by electrospinning for the treatment of...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Katarzyna Klimek

Uniwersytet Medyczny w Lublinie

Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Anna Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

Myeloid cell subpopulations as a source of effector cells for anticancer therapies using CAR chimeric receptors

Call: OPUS 25 , Panel: NZ6

Principal investigator: dr hab. Angelika Muchowicz

Warszawski Uniwersytet Medyczny, Wydział Lekarski

The effect of PKC epsilon modification on autophagy in cancer cells.

Call: OPUS 2 , Panel: NZ7

Principal investigator: prof. Maria Jolenta Rybczyńska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Angelika Pietrzak-Wawrzyńska

Instytut Farmakologii PAN

Unveiling the molecular signature underlying resistance to CD19 CAR-T therapy in malignant cells.

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marta Krawczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Potential of TH cell profiling in personalized multiple sclerosis treatmentplanning.

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Donskow-Łysoniewska

Uczelnia Łazarskiego

Precise molecular characterization of circulating tumour cells in patients with triple negative breast cancer using high...

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Stefano Volinia

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Dawid Dariusz Dorna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Smart tissue engineering to change the paradigm of diabetes treatment

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Marek Arkadiusz Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Bioabsorbable hydroxyapatite/polymer nanocomposite granules with enhanced osteoconductivity and anti-inflammatory proper...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: dr Vladyslav Vivcharenko

Uniwersytet Medyczny w Lublinie

Benchmarking Human Tissue Culture Systems that Mimic the Tumor Microenvironment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Matthias Nees

Uniwersytet Medyczny w Lublinie

An innovative method of treating acute liver failure using amniotic stem cells isolated from the human placenta.

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: dr Patrycja Lukrecja Wieczorek

Śląski Uniwersytet Medyczny w Katowicach, Centrum Medycyny Doświadczalnej

A novel approach based on the optimized multidrug combination for glioblastoma treatment.

Call: SONATA 16 , Panel: NZ7

Principal investigator: prof. Małgorzata Kucińska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Identification of potential markers aiming early diagnostics of progression and tailoring metastasis-oriented therapies ...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Natalia Bednarz-Knoll

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego