Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effect of PKC epsilon modification on autophagy in cancer cells.

2011/03/B/NZ7/06244

Keywords:

Protein kinase C epsilon regulation of gene expression cell death - apoptosis autophagy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Rybczyńska 

Number of co-investigators in the project: 4

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 270 000 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2015-08-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat LightCycler96 firmy Roche.
  2. Zestaw pipet automatycznych (7 000 PLN)
  3. Kaseta do wizualizacji klisz (4 500 PLN)
  4. Komputer z systemem antyprzepięciowym (8 000 PLN)
  5. Aparat SNAP do przeprowadzenia analizy western blot (5 000 PLN)
  6. Inkubator z dozownikiem.
  7. Kołyska horyzontalna (3 500 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. Beclin-1 and its role as a target for anticancer therapy
    Authors:
    Ewa Totoń, Natalia Lisiak, Paulina Sawicka, Maria Rybczyńska
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2014, tom: 65, strony: 459-467), Wydawca: Department of Physiology Jagiellonian University Medical College 16 Grzegórzecka Str., 31-531 Kraków, Poland
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Impact of PKCε downregulation at autophagy in glioblastoma cells.
    Authors:
    Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski, Maria Rybczynska
    Academic press:
    BMC Cancer (rok: 2018, tom: 0,878472222222222, strony: 45308), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12885-018-4095-1 - link to the publication
  3. Zapotin (5,6,2',6'-tetramethoxyflavone) Modulates the Crosstalk Between Autophagy and Apoptosis Pathways in Cancer Cells with Overexpressed Constitutively Active PKCε
    Authors:
    Ewa Toton, Aleksandra Romaniuk, Jaromir Budzianowski, Johann Hofmann, Maria Rybczynska
    Academic press:
    Nutrition and Cancer: An International Journal (rok: 2016, tom: Vol. 68, nr 2, strony: 290-304), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    nie - link to the publication
  1. Expression of the autophagy genes in cancer cells overexpressed constitutively active PKC epsilon.
    Authors:
    Ewa Totoń, Natalia Lisiak, Johann Hofmann, Maria Rybczyńska
    Conference:
    FEBS EMBO Conference. Paris, France (rok: 2014, ), Wydawca: FEBS Journal
    Data:
    konferencja 30 August-4 September
    Status:
    Published
  2. Influence of zapotin on mechanism of autophagy in cancer cells over-expressed constitutively active PKCε
    Authors:
    Ewa Totoń, Aleksandra Romaniuk, Natalia Lisiak, Johann Hofmann, Jaromir Budzianowski, Maria Rybczyńska
    Conference:
    BIO 2014 Congress. Warsaw, Poland (rok: 2014, ), Wydawca: Czasopismo: Acta Bioch. Pol.
    Data:
    konferencja September 9th-12th
    Status:
    Published
    DOI:
    link to the publication
  3. Rola bekliny 1 w autofagii komórek HeLa z nadekspresją PKCε.
    Authors:
    Paulina Sawicka, Ewa Totoń, Maria Rybczyńska.
    Conference:
    XVIII Zjazd Naukowy Polskiego Towarzystwa Diagnostyki Laboratoryjnej, Warszawa (rok: 2013, ), Wydawca: czasopismo: Diagnostyka Laboratoryjna (Journal of Laboratory Diagnostics), Fundacja Rozwoju Diagnostyki Laboratoryjnej
    Data:
    konferencja 15-18 IX 2013 r.
    Status:
    Published
    DOI:
    link to the publication
  4. The level and localization of LC3 protein in cancer cells with overexpressed PKCεA/E.
    Authors:
    Ewa Totoń, Zuzanna Kanduła, Maria Rybczyńska.
    Conference:
    48th Congress of the Polish Biochemical Society, Toruń, Poland (rok: 2013, ), Wydawca: Czasopismo: Acta Biochimica Polonica
    Data:
    konferencja September 2-5,
    Status:
    Published
  5. Zapotin (5,6,2',6'-tetramethoxy-flavone) modulates the crosstalk between autophagy and apoptosis pathways in cancer cells with overexpressed constitutively active PKCε. - ustna prezentacja wyników (dr Ewa Totoń)
    Authors:
    Ewa Totoń, Aleksandra Romaniuk, Jaromir Budzianowski, Johann Hofmann, Maria Rybczyńska
    Conference:
    Frontiers in Cancer Prevention: Fulfilled Promises, Translational Challenges and Future Directions, Gdańsk, Poland (rok: 2015, ), Wydawca: Czasopismo: Acta Bioch. Pol.
    Data:
    konferencja June 24th-27th,
    Status:
    Published
    DOI:
    link to the publication

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