Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Pharmacokinetics and organ distribution of treosulfan and its biologically active epoxy-transformers in rats

2014/13/D/NZ7/00278

Keywords:

hematopoietic stem cell transplantation tissues toxicity HPLC-MS/MS

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Romański 

Number of co-investigators in the project: 4

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 187 500 PLN

Project start date (Y-m-d): 2015-01-28

Project end date (Y-m-d): 2018-01-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator tkankowy (2 szt.) (25 000 PLN)
  2. Spektrofotometr.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method
    Authors:
    M. Romański, A. Kasprzyk, A. Teżyk, A. Widerowska, C. Żaba, F.K. Główka
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2017, tom: 140, strony: 122-129), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2017.03.023 - link to the publication
  2. Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: studies in a rat model with clinical relevance
    Authors:
    M. Romański, A. Kasprzyk, M. Walczak, A. Ziółkowska, F. Główka.
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2017, tom: 109, strony: 616-623), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.09.011 - link to the publication
  3. In Vivo Red Blood Cells/Plasma Partition Coefficient of Treosulfan and Its Active Monoepoxide in Rats
    Authors:
    M. Romański, A. Zacharzewska, A. Teżyk, F.K. Główka
    Academic press:
    European Journal of Drug Metabolism and Pharmacokinetics (rok: 2018, tom: 43, strony: 565-571), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13318-018-0469-7 - link to the publication
  4. Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives
    Authors:
    M. Romański, J. Wachowiak, F.K. Główka
    Academic press:
    Clinical Pharmacokinetics (rok: 2018, tom: 57, strony: 1255-1265), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/ - link to the publication
  5. Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results
    Authors:
    M. Romański, F. Główka
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2018, tom: 153, strony: 199-203), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jpba.2018.02.049 - link to the publication
  1. Distribution of treosulfan and its active monoepoxide into liver, lungs, femoral muscle, and brain in a rat model
    Authors:
    M. Romański, A. Kasprzyk, M. Walczak, F.K. Główka
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences "Towards novel concepts in pharmaceutical sciences" (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27 maja
    Status:
    Published
  2. Organ distribution of treosulfan and its biologically active monoepoxy-transformer in rats
    Authors:
    Anna Kasprzyk, Michał Romański, Franciszek Główka
    Conference:
    8th Polish-German Symposium on Pharmaceutical Sciences "Retrospects, insights and prospects" (rok: 2015, ), Wydawca: Kiel University (Christian-Albrechts-Universität zu Kiel)
    Data:
    konferencja 29-30 maja
    Status:
    Published
  3. Metoda HPLC-MS/MS oznaczania treosulfanu i jego monoepoksypochodnej w tkankach u szczurów
    Authors:
    Anna Kasprzyk, Michał Romański, Agnieszka Widerowska, Franciszek Główka
    Conference:
    Współczesna analityka farmaceutyczna i biomedyczna w ochronie zdrowia (rok: 2015, ), Wydawca: Komitet Terapii i Nauk o Leku PAN, Komisja Analizy Leku Polskie Towarzystwo Farmaceutyczne Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu
    Data:
    konferencja 17-18 września
    Status:
    Published
  4. HPLC-ESI-MS/MS analysis of prodrug treosulfan and its active monoepoxide in rat plasma, bone marrow, liver, lungs, brain, kidneys, and muscle
    Authors:
    M. Romański, A. Kasprzyk, A. Teżyk, C. Żaba, F. Główka.
    Conference:
    XXVIII International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017) (rok: 2017, ), Wydawca: Scientific Committee and Local Organizing Committee of the XXVIII International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017)
    Data:
    konferencja 2-5 lipca
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy