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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Search for novel mechanisms underlining inhibition of cancer cell proliferation by plant-derived nutraceuticals

2013/11/D/NZ7/00939

Keywords:

nutraceuticals cancer cells inhibition of cell proliferation

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Rzeszowski, Wydział Biotechnologii

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Lewińska 

Number of co-investigators in the project: 4

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 488 402 PLN

Project start date (Y-m-d): 2014-07-10

Project end date (Y-m-d): 2018-07-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Analizator komórek (ilość komórek, przeżywalność, cykl komórkowy) (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (7)
  1. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.
    Authors:
    Lewinska A, Jarosz P, Czech J, Rzeszutek I, Bielak-Zmijewska A, Grabowska W, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (rok: 2015, tom: 779, strony: 23-34), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2015.02.003 - link to the publication
  2. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Toxicology Letters (rok: 2017, tom: 265, strony: 117–130), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2016.11.018 - link to the publication
  3. Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Deregowska A, Wnuk M.
    Academic press:
    Theranostics (rok: 2017, tom: 7, strony: 3461-3477), Wydawca: Ivyspring International Publisher
    Status:
    Published
    DOI:
    10.7150/thno.20657 - link to the publication
  4. Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.
    Authors:
    Lewinska A, Bednarz D, Adamczyk-Grochala J, Wnuk M.
    Academic press:
    Redox Biology (rok: 2017, tom: 12, strony: 469-482), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2017.03.014 - link to the publication
  5. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
    Authors:
    Lewinska A, Siwak J, Rzeszutek I, Wnuk M.
    Academic press:
    Toxicology in Vitro (rok: 2015, tom: 29, strony: 417-425), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2014.12.005 - link to the publication
  6. Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells.
    Authors:
    Lewinska A, Adamczyk J, Pajak J, Stoklosa S, Kubis B, Pastuszek P, Slota E, Wnuk M.
    Academic press:
    Mutation Research - Genetic Toxicology and Environmental Mutagenesis (rok: 2014, tom: 771, strony: 43–52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrgentox.2014.07.001 - link to the publication
  7. Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide.
    Authors:
    Lewinska A, Chochrek P, Smolag K, Rawska E, Wnuk M.
    Academic press:
    Redox Report: Communications in Free Radical Research (rok: 2015, tom: 20, strony: 116-125), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1179/1351000214Y.0000000113 - link to the publication
  8. Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells.
    Authors:
    Lewinska A, Adamczyk-Grochala J, Kwasniewicz E, Deregowska A, Wnuk M.
    Academic press:
    Apoptosis (rok: 2017, tom: 22, strony: 800-815), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-017-1353-7 - link to the publication
  1. CYTOSTATIC AND PRO-SENESCENT ACTIVITY OF SULFORAPHANE IS MEDIATED BY DNA HYPOMETHYLATION AND CHANGES IN MICRORNA PROFILE IN BREAST CANCER CELLS
    Authors:
    Anna Lewinska, Jagoda Adamczyk-Grochala, Anna Deregowska, Maciej Wnuk.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (rok: 2017, ), Wydawca: National Hellenic Research Foundation
    Data:
    konferencja 16-19.10.2017
    Status:
    Published
  2. Pleiotropic anticancer activity of selected nutraceuticals against MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.
    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Maciej Wnuk.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (rok: 2016, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published
  3. Nutraceuticals induce ribotoxic stress in breast cancer cells MCF-7, MDA-MB-231 and SK-BR-3.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    Cell Fate Diversity in Aging Conference, Dubrovnik, Croatia (rok: 2016, ), Wydawca: Zing Conferences
    Data:
    konferencja 25-28.09.2016
    Status:
    Published
  4. A complex response to nutraceutical stimulation in phenotypically different breast cancer cell lines.
    Authors:
    Anna Lewinska, Jagoda Adamczyk, Anna Deregowska, Ewa Kwasniewicz, Maciej Wnuk.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (rok: 2016, ), Wydawca: Nencki Institute
    Data:
    konferencja 23-24.09.2016
    Status:
    Published
  5. Nutraceutical-induced ribotoxic stress in MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cell lines.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Anna Lewinska.
    Conference:
    41st FEBS Congress, Molecular and Systems Biology for a Better Life, Ephesus/Kuşadasi, Turkey (rok: 2016, ), Wydawca: John Wiley & Sons, Inc.
    Data:
    konferencja 3-8.09.2016 (planowana, ale odwołana; suplement jednak upowszechniono w FEBS Journal)
    Status:
    Published
  6. PHYTOCHEMICALS AFFECT NUCLEOLUS STATE AND INDUCE CELL CYCLE ARREST AND SENESCENCE IN BREAST CANCER CELLS
    Authors:
    Maciej Wnuk, Diana Bednarz, Jagoda Adamczyk-Grochala, Anna Lewinska.
    Conference:
    IUBMB Focused Meeting on Molecular aspects of aging and longevity, Athens, Greece (rok: 2017, ), Wydawca: National Hellenic Research Foundation
    Data:
    konferencja 16-19.10.2017
    Status:
    Published
  7. Ribotoxic stress and shifts in glycolytic pathway-based cytostatic action of selected nutraceuticals in breast cancer cells of different receptor status.
    Authors:
    Maciej Wnuk, Jagoda Adamczyk, Anna Deregowska, Diana Bednarz, Ewa Kwasniewicz, Anna Lewinska.
    Conference:
    FUTURE OF AGING, 10th European Congress of Biogerontology and 6th Biogerontological Meeting of the Polish Academy of Sciences, Nencki Institute, Warsaw, Poland (rok: 2016, ), Wydawca: Nencki Institute
    Data:
    konferencja 23-24.09.2016
    Status:
    Published

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