Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Effect of parabens and their mixtures on selected parameters related to the development of breast cancer in models og hormon-dependent human breast cancer MCF-7 cell lines and nontumorigenic human mammary epithelial MCF-10A cell lines.

2011/01/N/NZ7/00015

Keywords:

parabens breast cancer cosmetics

Descriptors:

  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

UNIWERSYTET JAGIELLOŃSKI, Wydział Biologii i Nauk o Ziemi, Instytut Zoologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Wróbel 

Number of co-investigators in the project: 2

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 250 680 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2014-06-06

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Precyzyjna mikrowaga analityczna (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Actions of methyl-, propyl- and butylparaben on estrogen receptor-α and -β and the progesterone receptor in MCF-7 cancer cells and non-cancerous MCF-10A cells
    Authors:
    Wróbel A., Gregoraszczuk EŁ
    Academic press:
    Toxicology Letters (rok: 2014, tom: 230, strony: 375–381), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1002/jat.2978 - link to the publication
  2. Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells.
    Authors:
    Anna Wróbel, Ewa Ł. Gregoraszczuk
    Academic press:
    Toxicology Letters (rok: 2015, tom: 238, strony: 110-116), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2015.08.001 - link to the publication
  3. Differential effect of methyl-, butyl- and propylparaben and 17β-estradiol on selected cell cycle and apoptosis gene and protein expression in MCF-7 breast cancer cells and MCF-10A non-malignant cells.
    Authors:
    Anna Maria Wróbel, Ewa Łucja Gregoraszczuk
    Academic press:
    Journal of Applied Toxicology (rok: 2014, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jat.2978. - link to the publication
  4. Effects of single and repeated in vitro exposure of three forms of parabens, methyl-, butyl- and propylparabens on the proliferation and estradiol secretion in MCF-7 and MCF-10A cells
    Authors:
    Anna Wróbel, Ewa Ł. Gregoraszczuk
    Academic press:
    Pharmacological Reports (rok: 2013, tom: 65, strony: 484-493), Wydawca: Institute of Pharmacology Polish Academy of Sciences
    Status:
    Published
    DOI:
    nie - link to the publication
  1. Effect of parabens on estradiol secretion and CYP19 gene and protein expression in MCF-7 breast cancer and MCF-10A breast epithelial cells
    Authors:
    Anna Wróbel, Ewa Ł. Gregoraszczuk
    Conference:
    The 3rd Winter Workshop of the Society for Biology of Reproduction "Central and Local Regulations of Reproductive Processes" (rok: 2013, ), Wydawca: Reproductive Biology
    Data:
    konferencja 30.01- 01.02
    Status:
    Published
    DOI:
    link to the publication

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