Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Epigentic regulation of angiogenesis induced by changes in methylation of histone proteins as a chance for new therapies in tumor disease

2012/05/B/NZ2/01663

Keywords:

endothelium angiogenesis postranslational modification of histones

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aneta Balcerczyk 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 789 100 PLN

Project start date (Y-m-d): 2013-01-24

Project end date (Y-m-d): 2016-11-23

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Sonikator - Diagenode Bioruptor Plus UCD-300 (60 000 PLN)
  2. MultiNa MCE-202 (Mikrochipowy system elektroforezy do analizy DNA i RNA) Shimadzu (150 000 PLN)
  3. Eco Real-Time PCR, Illumina (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells
    Authors:
    Aneta Balcerczyk, Dorota Rybaczek, Martyna Wojtala, Luciano Pirola, Jun Okabe, Assam El-Osta
    Academic press:
    Biochemical Pharmacology (rok: 2016, tom: 121, strony: 18-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2016.09.013 - link to the publication
  2. Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells
    Authors:
    Wojtala M, Dąbek A, Rybaczek D, Śliwińska A, Świderska E, Słapek K, El-Osta A, Balcerczyk A.
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 1212-1233), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8101212 - link to the publication
  3. The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting
    Authors:
    Luciano Pirola, Oskar Ciesielski, Aneta Balcerczyk
    Academic press:
    Cancers (rok: 2018, tom: 10, strony: 268-293), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers10080268 - link to the publication
  1. Angiostatic abilities of arginine/lysine histone methyltransferase inhibitors, AMI-1 and A(K)MI-5
    Authors:
    Aneta Balcerczyk, Dorota Rybaczek, Jun Okabe, Karolina Fornalczyk, Grzegorz Bartosz, Assam El-Osta
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics BIO 2014" (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12 września
    Status:
    Published
  2. Epigenetyczna regulacja procesu angiogenezy komórek śródbłonka mikrowaskularnego, warunkowana aktywnością metylotransferazy Set7/9
    Authors:
    Salamon A, Wojtala M, Dąbek A, Balcerczyk A.
    Conference:
    III Ogólnopolskiej Konferencji Naukowo-Szkoleniowej "Medycyna Personalizowana - GENOM, CZŁOWIEK, ŚWIAT, ZAGROŻENIA" (rok: 2016, ), Wydawca: Organizatorzy konferencji, wydawnictwo "Polihymnia"
    Data:
    konferencja 23-25 Listopada 2016
    Status:
    Published
    DOI:
    link to the publication
  3. The role of lysine-specific demethylase-1 (LSD-1) in the regulation of nitric oxide production of the microvascular endothelial cells
    Authors:
    Fornalczyk KP, Jung M, Bartosz G, Balcerczyk A
    Conference:
    International Cardiovascular Research Meeting (rok: 2015, ), Wydawca: Folia Medica Copernicana
    Data:
    konferencja 11-13.03.2015
    Status:
    Published
    DOI:
    link to the publication

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