Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The study of synergistic inhibition of tumor cell proliferation by CK2 casein kinase inhibitors and inhibitors of thymidylate synthase

2014/13/B/NZ7/02273

Keywords:

casein kinase CK2 thymidylate synthase anticancer agents

Descriptors:

  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bretner 

Number of co-investigators in the project: 10

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 093 450 PLN

Project start date (Y-m-d): 2015-02-02

Project end date (Y-m-d): 2019-02-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. inkubator z wytrząsaniem (40 000 PLN)
  2. Termocykler gradientowy (32 000 PLN)
  3. komora laminarna.
  4. komputer z drukarką i oprogramowaniem (2 szt.) (6 000 PLN)
  5. spektrofotometr UV/VIS z oprogramowaniem i przystawką do badania kinetyki (65 000 PLN)
  6. zamrażarka głębokiego mrożenia (-86oC) (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Human dihydrofolate reductase is a substrate of protein kinase CK2α
    Authors:
    Katarzyna Skierka; Paweł Wilamowski; Monika Wielechowska; Dominik Cysewski, Elżbieta Senkara; Patrycja Wińska; Maria Bretner; Joanna Cieśla
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2019, tom: 513, strony: 368-373), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2019.03.186 - link to the publication
  2. Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
    Authors:
    Wińska P, Skierka K, Łukowska-Chojnacka E, Koronkiewicz M, Cieśla J, Bretner M.
    Academic press:
    Anticancer Reserch (rok: 2018, tom: 38, strony: 4617-4627), Wydawca: International Institute of Anticancer Research
    Status:
    Published
    DOI:
    10.21873/anticanres.12766 - link to the publication
  3. Synthesis, in vitro antiproliferative activity and kinase profile of new benzimidazole and benzotriazole derivatives
    Authors:
    Konrad Chojnacki, Patrycja Winska, Katarzyna Skierka, Monika Wielechowska, Maria Bretner
    Academic press:
    Bioorganic Chemistry (rok: 2017, tom: 72, strony: 45301), Wydawca: elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Study of the physicochemical properties of protein kinase CK2 inhibitors -TBBt, TBBi and 2-Me-TBBi
    Authors:
    Edyta Łukowska-Chojnacka, Aneta Pobudkowska, Maria Bretner
    Academic press:
    Fluid Phase Equilibria (rok: 2019, tom: 479, strony: 52-62), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fluid.2018.09.015 - link to the publication
  5. Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity
    Authors:
    Paweł Borowiecki, Patrycja Winska, Maria Bretner, Małgorzata Gizinska, Mirosława Koronkiewicz, Monika Staniszewska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 150, strony: 307-333), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.02.077 - link to the publication
  6. Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases
    Authors:
    K. Chojnacki, P. Wińska, M. Wielechowska, E. Łukowska-Chojnacka, C. Tölzer, K. Niefind, M. Bretner
    Academic press:
    Bioorganic Chemistry (rok: 2018, tom: 80, strony: 266-275), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2018.06.022 - link to the publication
  7. Simultaneous inhibition of protein kinase CK2 and dihydrofolate reductase results in synergistic effect in acute lymphoblastic leukemia
    Authors:
    Patrycja Wińska, Łukasz Widło, Katarzyna Skierka, Alicja Krzyśko, Mirosława Koronkiewicz, Jarosław Cieśla, Joanna Cieśla, Maria Bretner
    Academic press:
    Anticancer Research (rok: 2019, tom: 39, strony: 3531-3542), Wydawca: Anticancer research
    Status:
    Published
    DOI:
    10.21873/anticanres.13499 - link to the publication

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