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In vitro assessment of selected protumorigenic effects favoring breast cancer development after exposure to silver nanoparticles in combination with common cosmetic constituents: aluminium salts, parabens, and phthalates

2012/07/B/NZ7/04197

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ1_1: Biologia molekularna
  • NZ6_8: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

INSTYTUT MEDYCYNY PRACY IM.PROF.DR MED.JERZEGO NOFERA W ŁODZI

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maciej Marek Stępnik

Number of co-investigators in the project: 10

Call

OPUS 4 – announced on 2012-09-15

Amount awarded
598 780 PLN
Project start date
2013-08-13
Project end date
2017-05-12
Project duration
45 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. System do oceny przenikalności substancji przez skórę (komory dyfuzyjne Franza). Cost: 50 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminium chloride, methyl paraben or di-n-butyl phthalate.

    Authors:
    Domeradzka-Gajda K, Nocuń M, Roszak J, Janasik B, Quarles CD Jr, Wąsowicz W, Grobelny J, Tomaszewska E, Celichowski G, Ranoszek-Soliwoda K, Cieślak M, Puchowicz D, Gonzalez JJ, Russo RE, Stępnik M.
    Academic press:
    Toxicology Letters (year: 2017, volume: 272, pages: 38–48), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2017.03.006 – link to the publication

  2. Genotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminium chloride, butylparaben or di-n-butylphthalate

    Authors:
    Roszak J., Domeradzka-Gajda K, Smok-Pieniążek A, Kozajda A, Spryszyńska S, Grobelny J, Tomaszewska E, Ranoszek-Soliwoda K, Cieślak M, Puchowicz D, Stępnik M
    Academic press:
    Toxicology in vitro (year: 2017, volume: 45, pages: 181-193), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2017.09.003 – link to the publication

  3. Inhibitory effect of silver nanoparticles on proliferation of estrogen-dependent MCF-7/BUS human breast cancer cells induced by butyl paraben or di-n-butyl phthalate

    Authors:
    Joanna Roszaka, Anna Smok-Pieniążek, Katarzyna Domeradzka-Gajda, Jarosław Grobelny, Emilia Tomaszewska, Katarzyna Ranoszek-Soliwoda, Grzegorz Celichowski, Maciej Stępnik
    Academic press:
    Toxicology and Applied Pharmacology (year: 2017, volume: 337, pages: 46377), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.taap.2017.10.014 – link to the publication

Articles in post-conference publications (5)

  1. Effect of selected cosmetic ingredients on the in vitro percutaneous absorption of silver nanoparticles

    Authors:
    Stępnik M, Nocuń M, Domeradzka K, Roszak J, Janasik B, Wąsowicz W, Grobelny J, Tomaszewska E, Soliwoda K, Cieślak M, Puchowicz D
    Conference:
    EUROTOX 2015 Porto-Portugal (year: 2015, pages: S207), Publisher: Toxicology Letters, Abstracts / Toxicology Letters 238S (2015) S56–S383
    Date:
    conference 13-16 września
    Status:
    Published
    DOI:
    link to the publication

  2. Polaryzation of phorbol myristate acetate-induced THP-1 macrophages following exposure to silver nanoparticles alone or in combination with aluminum chloride, butylparaben or dibutylphthalate

    Authors:
    J. Roszak, K. Domeradzka-Gajda, A. Smok-Pieniążek, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz, M. Stępnik
    Conference:
    NanoSafe2016 (year: 2016, pages: 272), Publisher: Minatec, Grenoble
    Date:
    conference 7-10 listopada 2016
    Status:
    Published

  3. Combined effect of silver nanoparticles and other cosmetic additives on viability of human breast cell lines

    Authors:
    J. Roszak, S. Spryszynska, A. Smok-Pieniążek, M. Nocuń, K. Domeradzka, W. Wasowicz, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz, M. Stępnik
    Conference:
    EUROTOX 2015 Porto-Portugal (year: 2015, pages: S207), Publisher: Toxicology Letters, Abstracts / Toxicology Letters 238S (2015) S56–S383
    Date:
    conference 13-16 września
    Status:
    Published
    DOI:
    link to the publication

  4. Mutagenicity testing in non-transformed and transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminum chloride, butylparaben, or dibutylphthalate

    Authors:
    Stępnik M, Domeradzka-Gajda K, Roszak J, Kozajda A, Smok-Pieniążek A, Grobelny J, Tomaszewska E, Celichowski G, Cieślak M, Puchowicz D
    Conference:
    ICONAN2016 (year: 2016, pages: 167), Publisher: University Pierre and Marie Curie, Paris
    Date:
    conference 28-30 września 2016
    Status:
    Published
    DOI:
    link to the publication

  5. EFFECT OF SILVER NANOPARTICLES AND SELECTED COSMETIC INGREDIENTS ON ESTROGEN-DEPENDENT PROLIFERATION OF HUMAN CANCER BREAST CELL LINE

    Authors:
    J. Roszak, S. Spryszyńska, A. Smok-Pieniążek, M. Nocuń, W. Wąsowicz, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz and M. Stępnik
    Conference:
    7th POLISH CONFERENCE ON NANOTECHNOLOGY (year: 2015, pages: Book of Abstracts 215), Publisher: Centrum NanoBiomedyczne, Uniwersytet im. Adama Mickiewicza w Poznaniu
    Date:
    conference 24-27, czerwca
    Status:
    Published

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