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Search for the mechanisms of the modulation of canonical Wnt signaling which effectively attenuate the survival of head and neck squamous cell carcinoma cells

2014/13/D/NZ7/00300

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Jarosław Jan Paluszczak

Number of co-investigators in the project: 3

Call

SONATA 7 – announced on 2014-03-17

Amount awarded
771 040 PLN
Project start date
2015-01-28
Project end date
2018-07-27
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Mikroskop fluorescencyjny z możliwością obserwacji wzrostu komórek w czasie rzeczywistym i wykonywania zdjęć. Cost: 42 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. Kanoniczna ścieżka sygnałowa Wnt – funkcjonalna struktura oraz znaczenie w płaskonabłonkowych nowotworach głowy i szyi

    Authors:
    Robert Kleszcz
    Academic press:
    Postępy Biochemii (year: 2019, volume: 65, pages: 183-192), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2019_268 – link to the publication

  2. The inhibition of CBP/β-catenin and Porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cell lines

    Authors:
    Robert Kleszcz, Anna Szymańska, Violetta Krajka-Kuźniak, Wanda Baer-Dubowska, Jarosław Paluszczak
    Academic press:
    Cellular Oncology (year: 2019, volume: 42, pages: 505-520), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13402-019-00440-4 – link to the publication

  3. The comparison of the effects of panobinostat and PKF118-310 on β-catenin-dependent transcription in head and neck squamous cell carcinoma cell lines

    Authors:
    Paluszczak Jarosław, Kleszcz Robert, Witczak Olga, Krajka-Kuźniak Violetta
    Status:
    Accepted for publication

Articles in post-conference publications (5)

  1. Modulation of Wnt signaling by natural and synthetic compounds in cancer cells

    Authors:
    Jarosław Paluszczak, Robert Kleszcz, Aleksandra Majchrzak-Celińska, Elżbieta Studzińska-Sroka, Violetta Krajka-Kuźniak, Wanda Baer-Dubowska
    Conference:
    Congress BIO2018 (year: 2018, pages: 164), Publisher: Acta Biochimica Polonica
    Date:
    conference 18-21 września
    Status:
    Published
    DOI:
    link to the publication

  2. Modulation of Wnt signaling target gene expression by decitabine, panobinostat, PKF118-310 and niclosamide in head and neck squamous cell carcinoma cell lines

    Authors:
    Paluszczak J, Kleszcz R, Krajka-Kuźniak V, Baer-Dubowska W.
    Conference:
    8th International Conference of Contemporary Oncology (year: 2016, pages: 51), Publisher: Contemporary Oncology , vol.19, Suppl.1
    Date:
    conference 16-18.03.2016
    Status:
    Published

  3. The comparison of the effects of Wnt pathway modulators - lithium chloride and PKF118-310 and epigenetic modulators - decitabine and panobinostat on Wnt target gene expression in normal, dysplastic and oral carcinoma cell lines

    Authors:
    Kleszcz R, Paluszczak J, Witczak O, Baer-Dubowska W.
    Conference:
    BIO 2016 Congress, 2nd Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics, 50th Meeting of the Polish Biochemical Society, 13th Conference of the Polish Society for Cell Biology (year: 2016, pages: vol. 63, S.2, s. 33), Publisher: Acta Biochimica Polonica
    Date:
    conference 13-16.09
    Status:
    Published
    DOI:
    link to the publication

  4. Targeted inhibition of Wnt pathway in cancer cell lines

    Authors:
    Paluszczak, Jarosław; Kleszcz, Robert; Baer-Dubowska, Wanda
    Conference:
    2nd European Cancer Epigenetics Conference (year: 2017, pages: 97), Publisher: X
    Date:
    conference 11-13.05
    Status:
    Published

  5. Wpływ wybranych inhibitorów kanonicznej ścieżki sygnałowej Wnt na przebieg cyklu komórkowego i apoptozę w liniach komórkowych płaskonabłonkowych nowotworów głowy i szyi

    Authors:
    Kleszcz R, Baer-Dubowska W, Paluszczak J.
    Conference:
    III Poznańskie Dni Cytometrii i Immunopatologii (year: 2018, pages: 24), Publisher: Wydawnictwo Naukowe Uniwersytetu Medycznego w Poznaniu
    Date:
    conference 24-25 maja
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski