Chemopreventive properties of polysaccharides isolated from edible Basidiomycete mushroom (Boletus edulis). In vitro and molecular studies in colon carcinoma cell culture model

2011/01/M/NZ7/02691

Keywords

Descriptors

  • NZ7_4: Prewencja populacyjna
  • NZ4_11: Biologia nowotworów
  • NZ5_9: Prewencja chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Wojciech Rzeski

Number of co-investigators in the project: 6

Call

HARMONIA 1 – announced on 2011-03-15

Amount awarded
223 600 PLN
Project start date
2011-12-20
Project end date
2013-12-19
Project duration
24 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (2)

  1. Boletus edulis biological active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells.

    Authors:
    Lemieszek MK, Cardoso C, Nunes FHFM, Barros AIRNA, Marques G, Pożarowski P, Rzeski W
    Academic press:
    Food and Function (year: 2013, volume: 4, pages: 575-585), Publisher: RSCPublishing
    Status:
    Published
    DOI:
    10.1039/c2fo30324h – link to the publication
  2. Boletus edulis ribonucleic acid – a potent apoptosis inducer in human colon adenocarcinoma cells.

    Authors:
    Lemieszek MK, Ribeiro M, Alves HG, Marques G, Nunes FM, Rzeski W
    Academic press:
    Food and Function (year: 2016, volume: 7, pages: 3163-3175), Publisher: RSCPublishing
    Status:
    Published
    DOI:
    10.1039/c6fo00132g – link to the publication

Articles in post-conference publications (2)

  1. Biopolymers isolated from Boletus edulis as an potent inhibitor of MAPK/ERK pathway in colon cancer cells.

    Authors:
    Lemieszek MK, Nunes FHFM, Rzeski W
    Conference:
    Cancer and Metabolism, Amsterdam, The Netherlands (year: 2013, pages: 60), Publisher: Abcam plc
    Date:
    conference 24-25.06.2013
    Status:
    Published
  2. Boletus edulis fraction exibitts antiproliferative and proapoptotic properties against colon cancer cell lines LS180 and HT-29.

    Authors:
    Lemieszek MK, Cardoso C, Barros AIRNA, Nunes FHFM, , Marques G, Pożarowski P, Rzeski W
    Conference:
    The 1st Symposium of the Cancer Research Center of Lyon, Lyon, France (year: 2013, pages: 101), Publisher: CRCL
    Date:
    conference 13-15.02.2013
    Status:
    Published

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