Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Searching for natural substances with antitubercular activity and their influence on the cell wall synthesis process in Mycobacterium tuberculosis H37Ra

2013/11/D/NZ7/01613

Keywords:

Mycobacterium tuberculossis H37Ra essentials oil Mutellina purpurea decaprenylphosphoryl-D-ribose oxidase DprE1,

Descriptors:

  • NZ7_1: Epidemiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Elwira Sieniawska 

Number of co-investigators in the project: 3

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 379 361 PLN

Project start date (Y-m-d): 2014-07-10

Project end date (Y-m-d): 2018-01-09

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer przenośny LENOVO IP B51-80 z wyposażeniem.
  2. Lampa UV (540 PLN)
  3. Mieszadło rolkowe hematologiczne.
  4. Rozbudowa autosamplera.
  5. Autosampler do chromatografu gazowego - System automatycznego dozowania próbek (34 250 PLN)
  6. Program epBlue - edytor do stacji pipetującej epMotion (11 000 PLN)
  7. Waga analityczna Pioneer (1 727 PLN)
  8. Wirówka Mini-6K/7K/10K z dodatkowymi rotorami (3 szt.) (3 159 PLN)
  9. Zielony filtr do systemu archiwizacji żeli (800 PLN)
  10. Homogenizator FastPrep24 Instrument (45 000 PLN)
  11. Program EndNote X7 downloading (1 550 PLN)
  12. Wyparka rotacyjna.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (5)
  1. Antimycobacterial activity of cinnamaldehyde in a Mycobacterium tuberculosis (H37Ra) model.
    Authors:
    Rafal Sawicki, Joanna Golus, Agata Przekora, Agnieszka Ludwiczuk, Elwira Sieniawska and Grazyna Ginalska
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2381), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23092381 - link to the publication
  2. Carrot seed essential oil—Source of carotol and cytotoxicity study
    Authors:
    Elwira Sieniawska, Łukasz´Swiatek, Barbara Rajtar, Ewelina Kozioł,Małgorzata Polz-Dacewicz, Krystyna Skalicka-Wozniak
    Academic press:
    Industrial Crops and Products (rok: 2016, tom: 92, strony: 109-115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.indcrop.2016.08.001 - link to the publication
  3. The Effect of Combining Natural Terpenes and Antituberculous Agents against Reference and Clinical Mycobacterium tuberculosis Strains
    Authors:
    Elwira Sieniawska, Rafal Sawicki, Marta Swatko-Ossor, Agnieszka Napiorkowska, Agata Przekora, Grazyna Ginalska and Ewa Augustynowicz-Kopec
    Academic press:
    Molecules (rok: 2018, tom: 23, 176, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23010176 - link to the publication
  4. Natural Terpenes Influence the Activity of Antibiotics against Isolated Mycobacterium tuberculosis
    Authors:
    Elwira Sieniawska, Marta Swatko-Ossor, Rafał Sawick, Krystyna Skalicka-Woźniak, Grazyna Ginalska
    Academic press:
    Medical Principles and Practise (rok: 2017, tom: 26, strony: 45308), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000454680 - link to the publication
  5. Nigella damascena L. Essential Oil—A Valuable Source of -Elemene for Antimicrobial Testing
    Authors:
    Elwira Sieniawska , Rafal Sawicki, Joanna Golus, Marta Swatko-Ossor, Grazyna Ginalska and Krystyna Skalicka-Wozniak
    Academic press:
    Molecules (rok: 2018, tom: 23, 256, strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23020256 - link to the publication
  6. The frequently occurring components of essential oils beta elemene and Rlimonene alter expression of dprE1 and clgR genes of Mycobacterium tuberculosis H37Ra
    Authors:
    Rafal Sawicki, Elwira Sieniawska, Marta Swatko-Ossor, Joanna Golus, Grazyna Ginalska
    Academic press:
    Food and Chemical Toxicology (rok: 2018, tom: 112, strony: 145-149), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fct.2017.12.052 - link to the publication
  7. Morphological Changes in the Overall Mycobacterium tuberculosis H 37 Ra Cell Shape and Cytoplasm Homogeneity due to Mutellina purpurea L. Essential Oil and Its Main Constituents
    Authors:
    Elwira Sieniawska, Marta Swatko-Ossor, Rafał Sawicki, Grażyna Ginalska
    Academic press:
    Medical Principles and Practice (rok: 2015, tom: 24, strony: 527-532), Wydawca: Karger AG, Basel
    Status:
    Published
    DOI:
    10.1159/000439351 - link to the publication
  1. How natural terpenes influence mycobacterial cell integrity?
    Authors:
    ELWIRA SIENIAWSKA, MARTA SWATKO-OSSOR, RAFAŁ SAWICKI, AGNIESZKA NAPIORKOWSKA, EWA AUGUSTYNOWICZ-KOPEĆ, GRAŻYNA GINALSKA
    Conference:
    3rd International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf. (rok: 2017, ), Wydawca: Organizing Committee of 3rd ICNPU
    Data:
    konferencja 18-21 October
    Status:
    Published
  2. METHOD DEVELOPMENT FOR EFFICIENT SEPARATION OF SABINENE FOR ANTIMYCOBACTERIAL TESTING
    Authors:
    SIENIAWSKA E, KOZIOŁ E, SWATKO-OSSOR M, SAWICKI R, GINALSKA G, SKALICKA-WOŹNIAK K
    Conference:
    International Symposium on Chromatography of Natural Products (rok: 2016, ), Wydawca: Chair and Dept. of Pharmacognosy with Medicinal Plant Unit of Medical University of Lublin
    Data:
    konferencja 6-9 czerwiec
    Status:
    Published
  3. The influence of natural terpenoids on the activity of tuberculostatic antibiotics.
    Authors:
    Elwira Sieniawska1*, Marta Swatko-Ossor2, Rafał Sawicki2, Grażyna Ginalska2
    Conference:
    International Symposioum on Essential Oils (rok: 2016, ), Wydawca: Badebio Ltd. Turkey
    Data:
    konferencja 11-14 wrzesień
    Status:
    Published
  4. DEVELOPMENT OF GC-MS METHOD FOR QUANTIFICATION OF SUGARS IN MYCOBACTERIAL BROTH
    Authors:
    SIENIAWSKA E, SWATKO-OSSOR M, SAWICKI R, GINALSKA G, LUDWICZUK A
    Conference:
    International Symposium on Chromatography of Natural Products (rok: 2016, ), Wydawca: Chair and Dept. of Pharmacognosy with Medicinal Plant Unit of Medical University of Lublin
    Data:
    konferencja 6-9 czerwiec
    Status:
    Published
  5. Nigella damascena L. essential oil - a source of β-elemene for antimycobacterial testing.
    Authors:
    ELWIRA SIENIAWSKA*, RAFAŁ SAWICKI, MARTA SWATKO-OSSOR, GRAŻYNA GINALSKA, KRYSTYNA SKALICKA-WOŹNIAK
    Conference:
    48th International Symposium on Essential Oils (ISEO2017) (rok: 2017, ), Wydawca: OOK-Press Ltd., Veszprém, Hungary
    Data:
    konferencja 10-13 September
    Status:
    Published

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