Synthesis and biological examination new functionalized of acridine/acridone derivatived as potential anticancer compounds with a special attention of melanoma and neuroblastoma
2014/13/B/NZ7/02234
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Politechnika Gdańska, Wydział Chemiczny
Voivodeship: pomorskie
Principal investigator (from the host institution)
prof. Krystyna Jolanta Dzierzbicka
Number of co-investigators in the project: 7
Call
OPUS 7 – announced on 2014-03-17
- Amount awarded
- 543 180 PLN
- Project start date
- 2015-01-28
- Project end date
- 2018-01-27
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Kriometr. Cost: 12 000 PLN
Information in the final report
Publication in academic press/journals (5)
-
Recent developments in the synthesis and biological activity of acridine/acridone analogues
- Authors:
- Gensicka-Kowalewska M., Cholewinski G., Dzierzbicka K.
- Academic press:
- RSC ADVANCES (year: 2017, volume: 7, pages: 15776-15804), Publisher: The Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/c7ra01026e – link to the publication
-
Tuftsin - Properties and Analogs
- Authors:
- Siebert A., Gensicka-Kowalewska M. Cholewinski G., Dzierzbicka K.
- Academic press:
- Curr. Med. Chem. (year: 2017, volume: 24, pages: 3711-3727), Publisher: Bentham Science
- Status:
- Published
- DOI:
- 10.2174/0929867324666170725140826 – link to the publication
-
Inhibitors of angiogenesis in cancer therapy - synthesis and biological activity
- Authors:
- Monika Gensicka, Agnieszka Głowacka, Krystyna Dzierzbicka, Grzegorz Cholewiński
- Academic press:
- Curr. Med. Chem. (year: 2015, volume: 22 (33), pages: 3830-3847), Publisher: Bentham Science Publishers
- Status:
- Published
- DOI:
- 10.2174/0929867322666150904111442 – link to the publication
-
Synthesis and biological evaluation of acridine/acridone analogs as potential anticancer agents.
- Authors:
- Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor, Krystyna Dzierzbicka
- Academic press:
- Medicinal Chemistry (year: 2019, volume: 15(7), pages: 729-737), Publisher: Bentham Science Publisher
- Status:
- Published
- DOI:
- 10.2174/1573406414666181015145120 – link to the publication
-
Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma.
- Authors:
- Miroslawa Cichorek, Anna Ronowska, Monika Gensicka-Kowalewska, Milena Deptula, Iwona Pelikant-Malecka, Krystyna Dzierzbicka
- Academic press:
- Journal of Cancer Research and Clinical Oncology (year: 2019, volume: 145, pages: 165–179), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00432-018-2776-4 – link to the publication
Articles in post-conference publications (9)
-
Synthesis and cytotoxic activity of the retro-tuftsin analogues of acridone.
- Authors:
- M. Gensicka-Kowalewska, M. Cichorek, M. Deptuła, A. Ronowska, K. Dzierzbicka
- Conference:
- 18th Tetrahedron Symposium (year: 2017, pages: P3.35), Publisher: Elsevier
- Date:
- conference 27-30 Czerwiec
- Status:
- Published
-
Synteza oligopeptydów jako nośników związków biologicznie czynnych
- Authors:
- Monika Gensicka Agnieszka Głowacka, Grzegorz Cholewiński, Krystyna Dzierzbicka
- Conference:
- 58 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2015, pages: 297), Publisher: Polskie Towarzystwo Chemiczne
- Date:
- conference 21-25 września
- Status:
- Published
-
Synteza fragmentów peptydowych nowych analogów heterocyklicznych
- Authors:
- Monika Gensicka, Agnieszka Głowacka, Krystyna Dzierzbicka, Grzegorz Cholewiński
- Conference:
- 58 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2015, pages: 296), Publisher: Polskie Towarzystwo Chemiczne
- Date:
- conference 21-25 września
- Status:
- Published
-
Porównanie odczynników kondensujących w syntezie oligopeptydów
- Authors:
- Monika Gensicka
- Conference:
- BioOrg I Wielkopolskie Sympozjum Chemii Bioorganicznej, Organicznej i Biomateriałów (year: 2015, pages: 186), Publisher: Politechnika Poznańska
- Date:
- conference 05 grudzień
- Status:
- Published
-
Synthesis and cytotoxic activity of the novel peptide derivatives of 4-methyl-acridine.
- Authors:
- M. Gensicka-Kowalewska, M. Cichorek, M. Deptuła, A. Ronowska, K. Dzierzbicka
- Conference:
- 24th Polish Peptide Symposium (year: 2017, pages: 72), Publisher: Dapartment of Biomedical Chemistry Faculty of Chemistry, University of Gdańsk
- Date:
- conference 3-7 Wrzesień
- Status:
- Published
-
Synteza oligopeptydowych analogów akrydyny/akrydonu.
- Authors:
- M. Gensicka, K. Dzierzbicka
- Conference:
- Postępy syntezy organicznej, Gdańsk, (year: 2016, pages: 59), Publisher: Gdansk University of Technology
- Date:
- conference 23-25 June
- Status:
- Published
-
Synthesis and cytotoxic activity of the peptide analogues of acridine.
- Authors:
- M. Gensicka, K. Dzierzbicka, G. Cholewinski, P. Trzonkowski,
- Conference:
- 17th Tetrahedron Symposium (year: 2016, pages: 34 [P1.031]), Publisher: Elsevier
- Date:
- conference 28 June -1 July
- Status:
- Published
-
Cytotoxic activity of the peptide analogues of acridine/acridone.
- Authors:
- M. Gensicka-Kowalewska, M. Cichorek, M. Deptuła, A. Ronowska, K. Dzierzbicka
- Conference:
- 18th Tetrahedron Symposium (year: 2017, pages: P3.32), Publisher: Elsevier
- Date:
- conference 27-30 Czerwiec
- Status:
- Published
-
The novel analogues of acridone and peptides and its biological activity.
- Authors:
- M. Gensicka, K. Dzierzbicka, G. Cholewinski, P. Trzonkowski
- Conference:
- 17th Tetrahedron Symposium (year: 2016, pages: 45 [P1.043]), Publisher: Elsevier
- Date:
- conference 28 June -1 July
- Status:
- Published