Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of tetrabromobisphenol A neurotoxicity

2012/05/B/NZ7/03225

Keywords:

tetrabromobisphenol A neurotoxicity oxidative stress mitochondrial dysfunction calcium excitotoxicity

Descriptors:

  • NZ7_15:
  • NZ7_2:
  • NZ3_6:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Wiesław Łazarewicz 

Number of co-investigators in the project: 4

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 514 960 PLN

Project start date (Y-m-d): 2013-01-25

Project end date (Y-m-d): 2017-01-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (20 000 PLN)
  2. Autoklaw (10 000 PLN)
  3. Mikroskop stereoskopowy z zimnym oświetleniem kierunkowym, kamerą i komputerem z oprogramowaniem do analizy obrazu. (60 000 PLN)
  4. Zestaw do elektroforezy (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (18)
  1. Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A.
    Authors:
    Lenart J, Zieminska E, Diamandakis D, Lazarewicz JW.
    Academic press:
    NeuroToxicology (rok: 2017, tom: 63, strony: 126-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuro.2017.09.014 - link to the publication
  2. Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells.
    Authors:
    Zieminska E, Lenart J, Lazarewicz JW.
    Academic press:
    Toxicology (rok: 2016, tom: 370, strony: 86-93), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2016.09.013. - link to the publication
  3. The Role of Ca2+ Imbalance in the Induction of Acute Oxidative Stress and Cytotoxicity in Cultured Rat Cerebellar Granule Cells Challenged with Tetrabromobisphenol A.
    Authors:
    Zieminska E, Lenart J, Diamandakis D, Lazarewicz JW.
    Academic press:
    Neurochemical Research (rok: 2017, tom: 42, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-016-2075-x - link to the publication
  4. Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Albrecht J, Lazarewicz JW.
    Academic press:
    Neurotox Res. (rok: 2015, tom: 28, strony: 195-208), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-015-9546-8 - link to the publication
  5. Bastadin 12 and ryanodine reveal similarities between thapsigargin- and tetrabromobisphenol A-induced intracellular Ca2+ release in cultured cerebellar granule cells.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Lazarewicz JW.
    Academic press:
    J. Physiol. Pharmacol. (rok: 2014, tom: 65, strony: 679-686), Wydawca: POLISH PHYSIOLOGICAL SOCIETY
    Status:
    Published
  6. Tetrabromobisphenol A disturbs zinc homeostasis in cultured cerebellar granule cells: A dual role in neurotoxicity.
    Authors:
    Zieminska E, Ruszczynska A, Lazarewicz JW.
    Academic press:
    Food Chem Toxicol. (rok: 2017, tom: 109 (Pt 1), strony: 363-375), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fct.2017.09.021 - link to the publication
  7. The Role of Ca2+ Imbalance in the Induction of Acute Oxidative Stress and Cytotoxicity in Cultured Rat Cerebellar Granule Cells Challenged with Tetrabromobisphenol A.
    Authors:
    Zieminska E, Lenart J, Diamandakis D, Lazarewicz JW.
    Academic press:
    Neurochemical Research (rok: 2017, tom: 42, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-016-2075-x - link to the publication
  8. Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A.
    Authors:
    Lenart J, Zieminska E, Diamandakis D, Lazarewicz JW.
    Academic press:
    NeuroToxicology (rok: 2017, tom: 63, strony: 126-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuro.2017.09.014 - link to the publication
  9. Bastadin 12 and ryanodine reveal similarities between thapsigargin- and tetrabromobisphenol A-induced intracellular Ca2+ release in cultured cerebellar granule cells.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Lazarewicz JW.
    Academic press:
    J. Physiol. Pharmacol. (rok: 2014, tom: 65, strony: 679-686), Wydawca: POLISH PHYSIOLOGICAL SOCIETY
    Status:
    Published
    DOI:
    brak - link to the publication
  10. Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells.
    Authors:
    Zieminska E, Lenart J, Lazarewicz JW.
    Academic press:
    Toxicology (rok: 2016, tom: 370, strony: 86-93), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2016.09.013. - link to the publication
  11. Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Albrecht J, Lazarewicz JW.
    Academic press:
    Neurotox Res. (rok: 2015, tom: 28, strony: 195-208), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-015-9546-8 - link to the publication
  12. Tetrabromobisphenol A-induced depolarization of rat cerebellar granule cells: ex vivo and in vitro studies
    Authors:
    Dominik Diamandakis, Elzbieta Zieminska, Marcin Siwiec, Krzysztof Tokarski, Elzbieta Salinska, Jacek Lenart, Grzegorz Hess, Jerzy W. Lazarewicz
    Status:
    Accepted for publication
  1. Triggering role of Ca2+ imbalance in the induction of acute oxidative stress and cytotoxicity in primary cultures of rat cerebellar granule cells challenged with TBBPA.
    Authors:
    Ziemińska E., Lenatr J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (4), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  2. SNAP-25: potential link between genetic and environmental causes of autism
    Authors:
    Ziemińska E., Lenatr J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (3), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  3. Terabromobisphenol-A-evoked oxidative stress and cytotoxicity in cultured neurons: involvement of zinc.
    Authors:
    Ziemińska E, Salińska E, Lazarewicz JW.
    Conference:
    51st Congress of the European Societies of Toxicology (EUROTOX 2015), Porto, Portugal (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16.09.2015
    Status:
    Published
  4. The role of oxidative stress in cytotoxicity evoked by tetrabromobisphenol A in primary cultures of rat cerebellar granule cells.
    Authors:
    Zieminska E, Lenart J., Lazarewicz JW.
    Conference:
    The 12th International Symposium: Molecular Basis of Pathology and Therapy in Neurological Disorders. Warsaw, Poland, November 20-21, 2014. (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja November 20-21, 2014
    Status:
    Published
  5. Is DCF test a suitable tool for the evaluation of tetrabromobisphenol A-induced oxidative stress in cultured neurons?
    Authors:
    Diamandakis D, Ziemińska E., Lenart J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (3), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  6. Terabromobisphenol-A modulates activity of NMDA receptors in isolated fractions of rat brain cortical membranes and depolarizes cultured neurons.
    Authors:
    Diamandakis D, Salińska E, Ziemińska E, Lazarewicz JW.
    Conference:
    51st Congress of the European Societies of Toxicology (EUROTOX 2015), Porto, Portugal (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16.09.2015
    Status:
    Published
  7. Tetrabromobisphenol A directly interferes with activity of NMDA receptors in cultured neurons and isolated cortical membranes.
    Authors:
    Diamandakis D, Ziemińska E, Salińska E, Łazarewicz JW.
    Conference:
    The 12th International Congress of the Polish Neuroscience Society, Gdańsk, Poland (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology and Polish Neuroscience Society, Warsaw, Poland
    Data:
    konferencja 6-8.09.2015
    Status:
    Published
  8. Tetrabromobisphenol A- induced oxidative stress in primary cultures of rat cerebellar granule cells: triggering role of Ca2+ imbalance.
    Authors:
    Ziemińska E, Lenart J, Łazarewicz JW.
    Conference:
    The 12th International Congress of the Polish Neuroscience Society, Gdańsk, Poland (rok: 2015, ), Wydawca: Nencki Institute of Experimental Biology and Polish Neuroscience Society, Warsaw, Poland
    Data:
    konferencja 6-8.09.2015
    Status:
    Published
  9. The role of oxidative stress in cytotoxicity evoked by tetrabromobisphenol A in primary cultures of rat cerebellar granule cells.
    Authors:
    Zieminska E, Lenart J., Lazarewicz JW.
    Conference:
    The 12th International Symposium: Molecular Basis of Pathology and Therapy in Neurological Disorders. Warsaw, Poland, November 20-21, 2014. (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja November 20-21, 2014
    Status:
    Published
  10. Bastadin 12 is a new tool useful in the study of mechanisms of intracellular calcium release evoked by thapsigargin and tetrabromobisphenol A.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Lazarewicz JW.
    Conference:
    The 12th International Symposium: Molecular Basis of Pathology and Therapy in Neurological Disorders. Warsaw, Poland (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja November 20-21, 2014
    Status:
    Published
  11. Is DCF test a suitable tool for the evaluation of tetrabromobisphenol A-induced oxidative stress in cultured neurons?
    Authors:
    Diamandakis D, Ziemińska E., Lenart J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (3), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  12. Putative role of intracellular Ca2+ stores in epileptogenesis.
    Authors:
    Łazarewicz JW, Ziemińska E.
    Conference:
    6 konferencja "Postępy w badaniach nad padaczką i lekami przeciwpadaczkowymi" Lublin (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 15 maja 2014 r.
    Status:
    Published
  13. Mechanisms of calcium imbalance in tetrabromobisphenol A-induced neurotoxicity
    Authors:
    Jerzy W. Łazarewicz, Dominik Diamandakis, Elżbieta Ziemińska, Elżbieta Salińska
    Conference:
    XIX International Congress of the Polish Pharmacological Society, Świnoujście, Poland. (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 17th - 19th September 2015
    Status:
    Published
  14. Bastadin 12 is a new tool useful in the study of mechanisms of intracellular calcium release evoked by thapsigargin and tetrabromobisphenol A.
    Authors:
    Zieminska E, Stafiej A, Toczylowska B, Lazarewicz JW.
    Conference:
    The 12th International Symposium: Molecular Basis of Pathology and Therapy in Neurological Disorders. Warsaw, Poland (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja November 20-21, 2014
    Status:
    Published
  15. Putative role of intracellular Ca2+ stores in epileptogenesis.
    Authors:
    Łazarewicz JW, Ziemińska E.
    Conference:
    6 konferencja "Postępy w badaniach nad padaczką i lekami przeciwpadaczkowymi" Lublin (rok: 2014, ), Wydawca: Elsevier
    Data:
    konferencja 15 maja 2014 r.
    Status:
    Published
  16. SNAP-25: potential link between genetic and environmental causes of autism
    Authors:
    Ziemińska E., Lenatr J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (3), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  17. Triggering role of Ca2+ imbalance in the induction of acute oxidative stress and cytotoxicity in primary cultures of rat cerebellar granule cells challenged with TBBPA.
    Authors:
    Ziemińska E., Lenatr J., Łazarewicz J.W.
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica, vol. 54 (4), editor: TERMEDIA
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  18. Terabromobisphenol-A-evoked oxidative stress and cytotoxicity in cultured neurons: involvement of zinc.
    Authors:
    Ziemińska E, Salińska E, Lazarewicz JW.
    Conference:
    51st Congress of the European Societies of Toxicology (EUROTOX 2015), Porto, Portugal (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 13-16.09.2015
    Status:
    Published

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