Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of peroxiredoxins 1 and 2 along with the thioredoxin-thioredoxin reductase system as new therapeutic targets in B cell lymphomas

2012/07/B/NZ7/04183

Keywords:

oxidative stress endoplasmic reticulum stress molecularly targeted therapies cancer lymphomas

Descriptors:

  • NZ1_1: Molecular biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_3: Apoptosis

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Radosław Zagożdżon 

Number of co-investigators in the project: 6

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 987 000 PLN

Project start date (Y-m-d): 2013-07-02

Project end date (Y-m-d): 2016-07-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Skaner preparatów histologicznych wraz z pakietem oprogramowania do immunohistochemii i mikromacierzy tkankowych (480 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells
    Authors:
    Marta Siernicka, Madgalena Winiarska, Malgorzata Bajor, Malgorzata Firczuk, Angelika Muchowicz, MAlgorzata Bobrowicz, Cyril Fauriat, Jakub Golab, Daniel Olive, Radoslaw Zagozdzon
    Academic press:
    Immunology (rok: 2015, tom: 146, strony: 173–183), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/imm.12494 - link to the publication
  2. Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma
    Authors:
    Anna Trzeciecka, Szymon Klossowski, Malgorzata Bajor, Radoslaw Zagozdzon, Pawel Gaj, Angelika Muchowicz, Agata Malinowska, Anna Czerwoniec, Joanna Barankiewicz, Antoni Domagala, Justyna Chlebowska, Monika Prochorec-Sobieszek, Magdalena Winiarska, Ryszard Ostaszewski, Iwonna Gwizdalska, Jakub Golab, Dominika Nowis, Malgorzata Firczuk
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 1717-1731), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.6435 - link to the publication
  3. SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress
    Authors:
    Angelika Muchowicz, Małgorzata Firczuk, Małgorzata Wachowska, Marek Kujawa, Ewa Jankowska-Steifer, Magdalena Gabrysiak, Zofia Pilch, Szymon Kłossowski, Ryszard Ostaszewski, Jakub Golab
    Academic press:
    Biochemical Pharmacology (rok: 2015, tom: 93, strony: 418-427), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2014.12.019 - link to the publication
  4. Adenanthin targets proteins involved in the regulation of disulphide bonds
    Authors:
    Angelika Muchowicz, Małgorzata Firczuk, Justyna Chlebowska, Dominika Nowis, Joanna Stachura, Joanna Barankiewicz, Anna Trzeciecka, Szymon Kłossowski, Ryszard Ostaszewski, Radosław Zagożdżon, Jian-Xin Pu, Han-Dong Sun, Jakub Golab
    Academic press:
    Biochemical Pharmacology (rok: 2014, tom: 89, strony: 210-216), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2014.02.022 - link to the publication

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