Evaluation of the contribution of telomerase regulation with TMPyP4 and cisplatin to multidrug resistance in breast cancer cells
2014/13/N/NZ7/00307
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ3_1: Biologia komórki
- NZ1_1: Biologia molekularna
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny, Katedra i Zakład Chemii Klinicznej i Diagnostyki Molekularnej
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
PRELUDIUM 7 – announced on 2014-03-17
- Amount awarded
- 149 910 PLN
- Project start date
- 2015-03-05
- Project end date
- 2019-03-04
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Kołyska/wytrząsarka horyzontalna. Cost: 6 000 PLN
Information in the final report
Publication in academic press/journals (3)
-
Na straży genomu: telomery i telomeraza - od odkrycia po badania kliniczne
- Authors:
- Natalia Lipińska, Błażej Rubiś
- Academic press:
- Acta Medicorum Polonorum (year: 2015, volume: 5, pages: 33-40), Publisher: Acta Medicorum Polonorum
- Status:
- Published
-
Telomerase inhibition with TMPyP4 alters adhesion and migration of breast cancer cells MCF7 and MDA-MB-231
- Authors:
- Natalia Konieczna, Aleksandra Romaniuk-Drapała, Natalia Lisiak, Ewa Totoń, Anna Paszel-Jaworska, Mariusz Kaczmarek, Błażej Rubiś
- Academic press:
- International Journal of Molecular Sciences (year: 2019, volume: 20, pages: 2670), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms20112670 – link to the publication
-
Telomerase and drug resistance in cancer
- Authors:
- Rubiś B, Lipińska N, Romaniuk A, Paszel-Jaworska A, Kopczyński P
- Academic press:
- Cellular and Molecular Life Sciences (year: 2017, volume: 74, pages: 4121-4132), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00018-017-2573-2 – link to the publication
Articles in post-conference publications (5)
-
Contribution of TMPyP4 and cisplatin to modulation of telomerase and survival of drug-resistant breast cancer cells
- Authors:
- Lipińska Natalia, Romaniuk Aleksandra, Kaczmarek Mariusz, Paszel-Jaworska Anna, Rubiś Błażej
- Conference:
- EMBO Young Scientists Forum 2016 (year: 2016, pages: 36), Publisher: EMBO
- Date:
- conference 1 - 2 September 2016
- Status:
- Published
-
Telomerase inhibitor TMPyP4 reduces adhesion and lifespan of human breast cancer cells and alters doxorubicin-mediated toxicity
- Authors:
- Natalia Lipińska, Aleksandra Romaniuk, Mariusz Kaczmarek, Błażej Rubiś
- Conference:
- 2nd Congress BIO2016 Expanding beyond the limits (year: 2016, pages: 180), Publisher: Acta Biochimica Polonica
- Date:
- conference 13 - 16 September 2016
- Status:
- Published
- DOI:
- link to the publication
-
Association of drug resistance induction and telomerase expression in cancer cells
- Authors:
- Lipińska Natalia, Romaniuk Aleksandra, Rubiś Błażej
- Conference:
- EMBO Young Scientists Forum 2015 (year: 2015, pages: 128), Publisher: EMBO
- Date:
- conference 2 - 3 July 2015
- Status:
- Published
-
Telomerase targeting modulates cancer response to therapy
- Authors:
- Natalia Konieczna, Aleksandra Romaniuk, Natalia Lisiak, Ewa Totoń, Anna Paszel-Jaworska, Błażej Rubiś
- Conference:
- BIO 2018 Congress (year: 2018, pages: 87), Publisher: Acta Biochimica Polonica
- Date:
- conference 18-21.09.2018
- Status:
- Published
-
Udział inhibitora telomerazy TMPyP4 w oporności komórek raka piersi na leki przeciwnowotworowe.
- Authors:
- Dominika Czerwik, Natalia Lipińska, Błażej Rubiś
- Conference:
- VIII Wykłady Otwarte z cyklu Spotkania Młodych z Nauką w Poznaniu (year: 2017, pages: 16), Publisher: Uniwersytet Medyczny im. K. Marcinkowskiego w Poznaniu
- Date:
- conference 08.04.2017
- Status:
- Published