Projects funded by the NCN


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42 projects found matching your search criteria :

  1. Activity of the opioid system in the pathogenesis and therapy of inflammatory disorders in mouse lines with high and low...

    Call: OPUS 7 , Panel: NZ4

    Principal investigator: dr hab. Jakub Jerzy Fichna

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  2. Impact of opioid-neurotensin chimera (PK20) on inflammation in murine model of contact sensitivity reaction and non-atho...

    Call: OPUS 7 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Kaczyńska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  3. Fentanyl opioid designer drugs: from molecular modeling to in vitro studies

    Call: OPUS 6 , Panel: ST4

    Principal investigator: prof. Joanna Sadlej

    Narodowy Instytut Leków

  4. The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associ...

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: dr Marta Zielińska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  5. Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  6. Identification of the crucial metabolic pathways in the central nervous system in the patophysiology of opioid dependenc...

    Call: OPUS 4 , Panel: NZ4

    Principal investigator: dr hab. Piotr Suder

    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

  7. Neural mechanisms underlying pathology of motivation.

    Call: SONATA BIS 2 , Panel: NZ3

    Principal investigator: dr Jan Manuel Rodriguez-Parkitna

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  8. Examine the importance of intracellular pathways in the action of opioids in microglial cells in vitro

    Call: PRELUDIUM 4 , Panel: NZ3

    Principal investigator: Katarzyna Popiołek-Barczyk

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  9. Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop...

    Call: MAESTRO 3 , Panel: NZ4

    Principal investigator: prof. Barbara Elżbieta Przewłocka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  10. Investigation of neuroprotective potency and mechanism of action of opioid-neurotensin hybrid peptides in organotypic hi...

    Call: PRELUDIUM 2 , Panel: NZ4

    Principal investigator: dr Patrycja Magdalena Kleczkowska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  11. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Jolanta Dyniewicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  12. Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Anika Marta Lasota

    Politechnika Łódzka, Politechnika Łódzka, Wydział Chemiczny,

  13. "I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr hab. Sabina Marta Podlewska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  14. Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Sławomir Hubert Filipek

    Uniwersytet Warszawski, Wydział Chemii

  15. The developmental changes in the endogenous opioid system associated with altered sensitivity to reward during adolescen...

    Call: PRELUDIUM 21 , Panel: NZ4

    Principal investigator: Klaudia Weronika Misiołek

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  16. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  17. New strategies in the pharmacotherapy of neuropathic pain based on modulation of the chemokine system and its influence ...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Joanna Gabriela Mika

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  18. Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

    Call: SONATA 17 , Panel: NZ5

    Principal investigator: dr Anna Piotrowska-Murzyn

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  19. Neurobiological mechanisms of migraine pain - role of opioid and NOP systems

    Call: SONATA BIS 11 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Małgorzata Targowska-Duda

    Uniwersytet Medyczny w Lublinie

  20. Role of opioid receptors in arterial hypertension. Examination of hypotensive action of biphalin, a synthetic non-addtic...

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: prof. Janusz Bogumił Sadowski

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  21. Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr Jan Manuel Rodriguez Parkitna

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  22. New therapies of opioid use disorder

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr Wojciech Barnaba Solecki

    Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

  23. Expression and function of Regulator of G Protein Signaling (RGS) proteins in physiological and pathophysiological condi...

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr hab. Maciej Stawnisław Sałaga

    Uniwersytet Medyczny w Łodzi

  24. Exploring new drug targets for efficacious therapy of neuropathic pain basing on the assessment and modulation of neuroi...

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr hab. Joanna Gabriela Mika

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  25. Investigation of novel functionally selective opioid receptors agonists

    Call: ETIUDA 8 , Panel: NZ7

    Principal investigator: Łucja Elżbieta Szumiec

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  26. Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Iwona Maria Inkielewicz-Stępniak

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  27. Kappa opioid receptors integrate neuronal signaling involved in social behavior

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  28. The role of kappa opioid receptors during chronic intestinal inflammation and colitis-associated colorectal cancer – foc...

    Call: SONATA 15 , Panel: NZ7

    Principal investigator: dr Marta Zielińska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  29. The effect of Hmmr gene and its interaction with the endogenous opioid system as a novel mechanism and a therapeutic tar...

    Call: SONATA 15 , Panel: NZ5

    Principal investigator: dr Dominik Stanisław Skiba

    Instytut Genetyki i Hodowli Zwierząt Polskiej Akademii Nauk

  30. Effects of a novel nonaddictive opioid on response to stress

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: dr Łucja Elżbieta Szumiec

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  31. Rational design and evaluation of functionally biased opioid agonists

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Ryszard Przewłocki

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  32. Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

    Call: SONATA 14 , Panel: ST5

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  33. New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 ...

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: dr Klaudia Kwiatkowski

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  34. Correlation between experimental and theoretical NMR shielding parameters for order and disorder molecular crystals of s...

    Call: PRELUDIUM 1 , Panel: ST4

    Principal investigator: Tomasz Pawlak

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  35. Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Barbara Elżbieta Przewłocka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  36. MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS S...

    Call: PRELUDIUM 14 , Panel: NZ2

    Principal investigator: Tomasz Maciej Stepniewski

    Uniwersytet Warszawski, Wydział Chemii

  37. Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Anna Piotrowska-Murzyn

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. The role of endogenous opioid peptides in the local regulation of prolactin secretion from the anterior pituitary in cyc...

    Call: PRELUDIUM 1 , Panel: NZ9

    Principal investigator: dr Kinga Tworus

    Uniwersytet Warmińsko-Mazurski w Olsztynie, WYDZIAŁ BIOLOGII

  39. The role of the endogenuous opioid system in prosocial behavior

    Call: OPUS 11 , Panel: NZ4

    Principal investigator: dr hab. Jan Manuel Rodriguez Parkitna

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  40. Search for new targets for an effective therapy of neuropathic pain and enhancement of opioids effects basing on the exa...

    Call: OPUS 11 , Panel: NZ4

    Principal investigator: prof. Joanna Gabriela Mika

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  41. Gene and protein analysis of OPRM1/MOR and OPRK1/KOR opioid receptors expression and neurobiological marker of nerve ter...

    Call: PRELUDIUM 1 , Panel: NZ4

    Principal investigator: Piotr Kazimierz Kupczyk

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  42. Rational design and pharmacological characterization of chimeric cyclic opioid peptide analogs targeting multiple recept...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Anna Ewa Janecka

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski