Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

2013/09/N/NZ7/00646

Keywords:

endomorphin-2 analogs analgesic activity antidepressant activity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Justyna Piekielna-Ciesielska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 134 070 PLN

Project start date (Y-m-d): 2014-03-12

Project end date (Y-m-d): 2017-09-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Kolumna preparatywna do HPLC: Jupiter 10u Proteo 90A 250*10,0 mm (4 200 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
    Authors:
    Piekielna J, Perlikowska R, do-Rego JC, do-Rego JL, Cerlesi MC, Calo G, Kluczyk A, Łapiński K, Tömböly C, Janecka A.
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2015, tom: 6, strony: 579-583), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.5b00056 - link to the publication
  2. Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]-NH2
    Authors:
    Piekielna-Ciesielska J, Mollica A, Pieretti S, Fichna J, Szymaszkiewicz A, Zielińska M, Kordek R, Janecka A.
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2018, tom: 33, strony: 560-566), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2018.1441839 - link to the publication
  3. Cyclopeptide Dmt-[D-Lys-p-CF3-Phe-Phe-Asp]NH2, a novel G protein-biased agonist of the mu opioid receptor
    Authors:
    Piekielna-Ciesielska J, Ferrari F, Calo' G, Janecka A.
    Academic press:
    Peptides (rok: 2018, tom: 101, strony: 227-233), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.peptides.2017.11.020 - link to the publication
  4. Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues.
    Authors:
    Adamska-Bartłomiejczyk A, Borics A, Tömböly C, Dvorácskó S, Lisowski M, Kluczyk A, Wołczański G, Piekielna-Ciesielska J, Janecka A.
    Academic press:
    Journal of Peptide Science (rok: 2017, tom: 23, strony: 864-870), Wydawca: European Peptide Society and John Wiley & Sons, Ltd.
    Status:
    Published
    DOI:
    10.1002/psc.3050 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy