Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associated colorectal cancer

2013/11/N/NZ7/00724

Keywords:

colitis-associated colorectal cancer endogenous opioid system inflammatory bowel diseases

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Zielińska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 149 071 PLN

Project start date (Y-m-d): 2014-09-22

Project end date (Y-m-d): 2018-09-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Tenapanor hydrochloride for the treatment of constipation-predominant irritable bowel syndrome.
    Authors:
    Zielińska M, Wasilewski A, Fichna J.
    Academic press:
    Expert Opinion Investigational Drugs (rok: 2015, tom: 24(8), strony: 1093-9), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1517/13543784.2015.1054480 - link to the publication
  2. Cyclic derivatives of morphiceptin possess anti‑transit effect in the gastrointestinal tract and alleviate abdominal pain in mice
    Authors:
    Agata Szymaszkiewicz, Jakub Włodarczyk, Marzena Mazur, Jacek Olczak, Jakub Fichna, Marta Zielińska
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 314-321), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00084-4 - link to the publication
  3. Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice
    Authors:
    Zielińska M, Jarmuż A, Sałaga M, Kordek R, Laudon M, Storr M, Fichna J.
    Academic press:
    Naunyn-Schmiedeberg's Arch Pharmacol (rok: 2016, tom: w druku, strony: w druku), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00210-016-1214-x - link to the publication
  4. Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice
    Authors:
    Marta Zielińska, Agata Szymaszkiewicz, Damian Jacenik, Lena Schodel, Maciej Sałaga, Hubert Zatorski, Radzisław Kordek, Christoph Becker , Wanda M Krajewska, Jakub Fichna
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 885, strony: 45302), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    European - link to the publication
  5. Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms
    Authors:
    Zielińska M, Jarmuż A, Sałaga M, Lipkowski AW, Fichna J.
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68(1), strony: 32-36), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.06.001 - link to the publication
  6. Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.
    Authors:
    Zielińska M, Ben Haddou T, Cami-Kobeci G, Sałaga M, Jarmuż A, Padysz M, Kordek R, Spetea M, Husbands SM, Fichna J
    Academic press:
    European Journal of Pharmacology (rok: 2015, tom: 765, strony: 582-590), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2015.09.021 - link to the publication
  7. Orally available extract from Brassica oleracea var. capitata rubra attenuates experimental colitis in mouse models of inflammatory bowel diseases
    Authors:
    Zielińska M, Lewandowska U, Podsędek A, Cygankiewicz AI, Jacenik D, Sałaga M, Kordek R, Krajewska WM, Fichna J
    Academic press:
    Journal of Functional Foods (rok: 2015, tom: 17, strony: 587–599), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1016/j.jff.2015.05.046 - link to the publication
  1. Activation of opioid receptors protects against development of colitis-associated colorectal cancer in mice
    Authors:
    Zielińska, M.; Jarmuż, A.; Jacenik, D.; Kordek, R.; Krajewska, W.; Fichna J.
    Conference:
    Federation of European Biochemical Societies (rok: 2017, ), Wydawca: Federation of European Biochemical Societies
    Data:
    konferencja 10-14.09.2017
    Status:
    Published
  2. PROTECTIVE EFFECT OF OPIOID RECEPTOR ACTIVATION IN THE DEVELOPMENT OF COLITIS-ASSOCIATED COLORECTAL CANCER IN MICE
    Authors:
    1.Jarmuż, A.; Jacenik, D.; Zatorski, H.; Kordek, R.; Krajewska, W.; Fichna, J.; Zielińska, M.
    Conference:
    United European Gastroenterology Week (rok: 2017, ), Wydawca: UEG
    Data:
    konferencja 28.10-1.11.2017
    Status:
    Published
    DOI:
    link to the publication
  1. Patient's Guide in Colorectal Cancer: Prophylaxis, Diet, and Lifestyle
    Authors:
    Marta Zielinska & Jakub Włodarczyk
    Book:
    Introduction to gastrointestinal diseases (rok: 2017, tom: 2, strony: 155-165), Wydawca: Springer
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy