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The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associated colorectal cancer

2013/11/N/NZ7/00724

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marta Zielińska

Number of co-investigators in the project: 3

Call

PRELUDIUM 6 – announced on 2013-09-16

Amount awarded
149 071 PLN
Project start date
2014-09-22
Project end date
2018-09-21
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (7)

  1. Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

    Authors:
    Zielińska M, Jarmuż A, Sałaga M, Lipkowski AW, Fichna J.
    Academic press:
    Pharmacological Reports (year: 2016, volume: 68(1), pages: 32-36), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.06.001 – link to the publication

  2. Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.

    Authors:
    Zielińska M, Ben Haddou T, Cami-Kobeci G, Sałaga M, Jarmuż A, Padysz M, Kordek R, Spetea M, Husbands SM, Fichna J
    Academic press:
    European Journal of Pharmacology (year: 2015, volume: 765, pages: 582-590), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2015.09.021 – link to the publication

  3. Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice

    Authors:
    Zielińska M, Jarmuż A, Sałaga M, Kordek R, Laudon M, Storr M, Fichna J.
    Academic press:
    Naunyn-Schmiedeberg's Arch Pharmacol (year: 2016, volume: w druku, pages: w druku), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00210-016-1214-x – link to the publication

  4. Orally available extract from Brassica oleracea var. capitata rubra attenuates experimental colitis in mouse models of inflammatory bowel diseases

    Authors:
    Zielińska M, Lewandowska U, Podsędek A, Cygankiewicz AI, Jacenik D, Sałaga M, Kordek R, Krajewska WM, Fichna J
    Academic press:
    Journal of Functional Foods (year: 2015, volume: 17, pages: 587–599), Publisher: Springer
    Status:
    Published
    DOI:
    10.1016/j.jff.2015.05.046 – link to the publication

  5. Cyclic derivatives of morphiceptin possess anti‑transit effect in the gastrointestinal tract and alleviate abdominal pain in mice

    Authors:
    Agata Szymaszkiewicz, Jakub Włodarczyk, Marzena Mazur, Jacek Olczak, Jakub Fichna, Marta Zielińska
    Academic press:
    Pharmacological Reports (year: 2020, volume: 72, pages: 314-321), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00084-4 – link to the publication

  6. Tenapanor hydrochloride for the treatment of constipation-predominant irritable bowel syndrome.

    Authors:
    Zielińska M, Wasilewski A, Fichna J.
    Academic press:
    Expert Opinion Investigational Drugs (year: 2015, volume: 24(8), pages: 1093-9), Publisher: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1517/13543784.2015.1054480 – link to the publication

  7. Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice

    Authors:
    Marta Zielińska, Agata Szymaszkiewicz, Damian Jacenik, Lena Schodel, Maciej Sałaga, Hubert Zatorski, Radzisław Kordek, Christoph Becker , Wanda M Krajewska, Jakub Fichna
    Status:
    Accepted for publication

Articles in post-conference publications (2)

  1. PROTECTIVE EFFECT OF OPIOID RECEPTOR ACTIVATION IN THE DEVELOPMENT OF COLITIS-ASSOCIATED COLORECTAL CANCER IN MICE

    Authors:
    1.Jarmuż, A.; Jacenik, D.; Zatorski, H.; Kordek, R.; Krajewska, W.; Fichna, J.; Zielińska, M.
    Conference:
    United European Gastroenterology Week (year: 2017, pages: 143-144), Publisher: UEG
    Date:
    conference 28.10-1.11.2017
    Status:
    Published
    DOI:
    link to the publication

  2. Activation of opioid receptors protects against development of colitis-associated colorectal cancer in mice

    Authors:
    Zielińska, M.; Jarmuż, A.; Jacenik, D.; Kordek, R.; Krajewska, W.; Fichna J.
    Conference:
    Federation of European Biochemical Societies (year: 2017, pages: 1), Publisher: Federation of European Biochemical Societies
    Date:
    conference 10-14.09.2017
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Patient's Guide in Colorectal Cancer: Prophylaxis, Diet, and Lifestyle

    Authors:
    Marta Zielinska & Jakub Włodarczyk
    Book:
    Introduction to gastrointestinal diseases (year: 2017, volume: 2, pages: 155-165), Publisher: Springer
    Status:
    Published

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