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Information on the principal investigator and host institution

Information of the project and the call

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Activity of the opioid system in the pathogenesis and therapy of inflammatory disorders in mouse lines with high and low sensitivity to stress

2014/13/B/NZ4/01179

Keywords:

gastroenteritis opioid system intestinal barrier stress-induced analgesia selected mouse lines

Descriptors:

  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jakub Fichna 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 800 800 PLN

Project start date (Y-m-d): 2015-04-21

Project end date (Y-m-d): 2017-10-20

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. High activity of endogenous opioid system protects against gastric damage development in mouse models of gastric mucosal injury
    Authors:
    Zatorski H, Salaga M, Zielińska M, Wasilewski A, Misicka A, Sacharczuk M, Fichna J
    Academic press:
    Pharmacol Rep (rok: 2019, tom: 71(2), strony: 218-224), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice
    Authors:
    Zielinska M, Szymaszkiewicz A, Salaga M, Zatorski H, Wlodarczyk J, Jacenik D, Kordek R, Krajewska WM, Misicka A, Fichna J, Sacharczuk M
    Academic press:
    J Physiol Pharmacol (rok: 2018, tom: 69(5), strony: 769-778), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.5.11 - link to the publication
  3. Prosecretory effect of loperamide in ileal and colonic mucosae of mice displaying high or low swim stress-induced analgesia associated with high and low endogenous opioid system activity
    Authors:
    Wasilewski A, Misicka A, Sacharczuk M, Fichna J
    Academic press:
    Neurogastroenterol Motil. (rok: 2018, tom: 30(2), strony: e13166), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/nmo.13166. - link to the publication
  4. The effect of opioid agonists and antagonists on gastrointestinal motility in mice selected for high and low swim stress-induced analgesia
    Authors:
    Wasilewski A, Lesniak A, Bujalska-Zadrozny M, Sadowski B, Fichna J, Sacharczuk M
    Academic press:
    Neurogastroenterol Motil. (rok: 2016, tom: 28(2), strony: 175-85), Wydawca: John Wiley & Sons, Inc.
    Status:
    Published
    DOI:
    10.1111/nmo.12704 - link to the publication
  5. Enkephalin degradation in serum of patients with inflammatory bowel diseases
    Authors:
    Wilenska B, Tymecka D, Włodarczyk M, Sobolewska-Włodarczyk A, Wiśniewska-Jarosińska M, Dyniewicz J, Somogyi Á, Fichna J, Misicka A
    Academic press:
    Pharmacol Rep. (rok: 2019, tom: 71(1), strony: 42-47), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.08.001 - link to the publication
  1. Increased expression of opioid receptors has an impact on the development of colonic inflammation in mice
    Authors:
    Agata Jarmuż, Aleksandra Misicka, Mariusz Sacharczuk; Supervisors: Prof. Jakub Fichna, PhD, Marta Zielińska, PhD
    Conference:
    3rd Lublin International Medical Congress for Students and Young Doctors (rok: 2016, ), Wydawca: -
    Data:
    konferencja 2-3.12
    Status:
    Published
    DOI:
    link to the publication
  2. Critical role of opioid receptor activity in central nervous system in determination of differences in gastrointestinal motility between mouse lines with high and low swim-stress-induced analgesia
    Authors:
    Wasilewski A, Lesniak A, Poznanski P, Bujalska-Zadrozny M, Sadowski B, Misicka A, Fichna J, Sacharczuk M
    Conference:
    11th International Conference on Immunopharmacology and Immunotoxicology (rok: 2017, ), Wydawca: Brak
    Data:
    konferencja 20-21.11
    Status:
    Published
  3. Disturbances in the immune system in mouse with high and low sensitivity to stress
    Authors:
    Karolina Bień, Piotr Orłowski, Jakub Fichna, Małgorzata Krzyżowska, Mariusz Sacharczuk
    Conference:
    I ZJAZD NAUKOWY POLSKIEGO TOWARZYSTWA BIOLOGII MEDYCZNEJ (rok: 2015, ), Wydawca: PTBMed
    Data:
    konferencja 26-31.05
    Status:
    Published
  4. Increased activity of endogenous opioid system prevents gastric damage induced by chronic stress
    Authors:
    Hubert Zatorski, Maciej Sałaga, Andrzej Wasilewski, Mariusz Sacharczuk, Jakub Fichna
    Conference:
    11th Warsaw International Medical Congress (rok: 2015, ), Wydawca: Termedia
    Data:
    konferencja 7-10.05
    Status:
    Published

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