Rational design and evaluation of functionally biased opioid agonists
2018/31/B/NZ7/03954
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Farmakologii PAN
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 9
Call
OPUS 16 – announced on 2018-09-14
- Amount awarded
- 2 495 020 PLN
- Project start date
- 2019-07-24
- Project end date
- 2025-07-23
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project completed
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl—Simulated Interaction Patterns Confronted with Experimental Data.
- Authors:
- Podlewska, S., Bugno, R., Kudla, L., Bojarski, A. J. i Przewlocki, R.
- Academic press:
- Molecules (volume: 25(20)), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules25204636 – link to the publication
-
Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors
- Authors:
- Kudla, L. i Przewlocki, R.
- Academic press:
- Pharmacological Reports (pages: 1033-1051), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s43440-021-00251-1 – link to the publication
-
Comparison of an Addictive Potential of µ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies
- Authors:
- Kudla L, Bugno R, Podlewska S, Szumiec L, Wiktorowska L, Bojarski AJ, Przewlocki R.
- Academic press:
- Pharmaceutics (volume: 14(1)), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/pharmaceutics14010055 – link to the publication