Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS SIDE EFFECTS

2017/27/N/NZ2/02571

Keywords:

OPIOID RECEPTOR GPCR ANALGESIS MOLECULAR DYNAMICS

Descriptors:

  • NZ2_10: Biological systems analysis, modelling and simulation
  • NZ2_8: Computational biology
  • NZ2_7: Bioinformatics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Tomasz Stepniewski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 156 520 PLN

Project start date (Y-m-d): 2018-06-29

Project end date (Y-m-d): 2025-06-28

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  • Book publications / chapters in book publications (1)
  1. Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody
    Authors:
    Mithu Baidya, Madhu Chaturvedi, Hemlata Dwivedi-Agnihotri, Ashutosh Ranjan, Dominic Devost, Yoon Namkung, Tomasz Maciej Stepniewski, Shubhi Pandey, Minakshi Baruah, Bhanupriya Panigrahi, Parishmita Sarma, Manish K Yadav, Jagannath Maharana, Ramanuj Banerjee, Kouki Kawakami, Asuka Inoue, Jana Selent, Stéphane A Laporte, Terence E Hébert, Arun K Shukla
    Academic press:
    Nature Communications (rok: 2022, tom: 13, strony: 4634), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-022-32386-x - link to the publication
  2. Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms
    Authors:
    Eshan Ghosh, Hemlata Dwivedi, Mithu Baidya, Ashish Srivastava, Punita Kumari, Tomek Stepniewski, Hee Ryung Kim, Mi-Hye Lee, Jaana van Gastel, Madhu Chaturvedi, Debarati Roy, Shubhi Pandey, Jagannath Maharana, Ramon Guixà-Gonzàlez, Louis M Luttrell, Ka Young Chung, Somnath Dutta, Jana Selent, Arun K Shukla
    Academic press:
    Cell reports (rok: 2019, tom: 28, strony: 32873299), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2019.08.053 - link to the publication
  3. Ligand entry pathways control the chemical space recognized by GPR183
    Authors:
    Tomasz Maciej Stępniewski, Viktoria Madeline Skovgaard Kjær, Brian Medel-Lacruz, Lisa Reinmuth, Marija Ciba, Elisabeth Rexen Ulven, Massimiliano Bonomi, Jana Selent, Mette Marie Rosenkilde
    Academic press:
    Chemical Science (rok: 2023, tom: 14, strony: 10671 - 10683,), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D2SC05962B - link to the publication
  4. Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism
    Authors:
    Richard Agren, Hugo Zeberg, Tomasz Maciej Stepniewski, R. Benjamin Free, Sean W. Reilly, Robert R. Luedtka, Peter Arhem, Francisco Ciruela, David R. Sibley, Robert H. Mach, Jana Selent, Johanna Nilsson, Kristogger Sahlholm
    Academic press:
    ACS Chemical Neuroscience (rok: 2020, tom: 11, strony: 3130 - 3143), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.0c00477 - link to the publication
  5. A highly conserved δ‐opioid receptor region determines RGS4 interaction
    Authors:
    Christos Karoussiotis, Maria Marti‐Solano, Tomasz Maciej Stepniewski, Alexandra Symeonof, Jana Selent, Zafiroula Georgoussi
    Academic press:
    The FEBS Journal (rok: 2019, tom: wydanie on-line, strony: wydanie on-line), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.15033 - link to the publication
  6. GPCRmd uncovers the dynamics of the 3D-GPCRome
    Authors:
    Ismael Rodríguez-Espigares, Mariona Torrens-Fontanals, Johanna KS Tiemann, David Aranda-García, Juan Manuel Ramírez-Anguita, Tomasz Maciej Stepniewski, Nathalie Worp, Alejandro Varela-Rial, Adrián Morales-Pastor, Brian Medel-Lacruz, Gáspár Pándy-Szekeres, Eduardo Mayol, Toni Giorgino, Jens Carlsson, Xavier Deupi, Slawomir Filipek, Marta Filizola, José Carlos Gómez-Tamayo, Angel Gonzalez, Hugo Gutierrez-de-Teran, Mireia Jiménez-Rosés, Willem Jespers, Jon Kapla, George Khelashvili, Peter Kolb, Dorota Latek, Maria Marti-Solano, Pierre Matricon, Minos-Timotheos Matsoukas, Przemyslaw Miszta, Mireia Olivella, Laura Perez-Benito, Davide Provasi, Santiago Ríos, Iván R Torrecillas, Jessica Sallander, Agnieszka Sztyler, Silvana Vasile, Harel Weinstein, Ulrich Zachariae, Peter W Hildebrand, Gianni De Fabritiis, Ferran Sanz, David E Gloriam, Arnau Cordomi, Ramon Guixà-González, Jana Selent
    Academic press:
    Nature Methods (rok: 2020, tom: 17, strony: 777-787), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41592-020-0884-y - link to the publication
  7. How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs
    Authors:
    Mariona Torrens-Fontanals, Tomasz Maciej Stepniewski, David Aranda-García, Adrián Morales-Pastor, Brian Medel-Lacruz, Jana Selent
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 5933), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165933 - link to the publication
  8. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
    Authors:
    Jenna Giubilaro, Doris A. Schuetz, Tomasz M. Stepniewski, Yoon Namkung, Etienne Khoury, Mónica Lara-Márquez, Shirley Campbell, Alexandre Beautrait, Sylvain Armando, Olivier Radresa, Jean Duchaine, Nathalie Lamarche-Vane, Audrey Claing, Jana Selent, Michel Bouvier, Anne Marinier, Stéphane A. Laporte
    Academic press:
    Nature Communication (rok: 2021, tom: 12, strony: 45307), Wydawca: Nature Communications
    Status:
    Published
    DOI:
    10.1038/s41467-021-249 - link to the publication
  9. Key phosphorylation sites in GPCRs orchestrate the contribution of β‐Arrestin 1 in ERK1/2 activation
    Authors:
    Mithu Baidya, Punita Kumari, Hemlata Dwivedi‐Agnihotri, Shubhi Pandey, Madhu Chaturvedi, Tomasz Maciej Stepniewski, Kouki Kawakami, Yubo Cao, Stéphane A Laporte, Jana Selent, Asuka Inoue, Arun K Shukla
    Academic press:
    EMBO reports (rok: 2020, tom: 21, strony: e49886), Wydawca: EMBO press
    Status:
    Published
    DOI:
    10.15252/embr.201949886 - link to the publication
  10. A molecular sensor for cholesterol in the human serotonin1A receptor
    Authors:
    Tomasz Maciej Stepniewski, G. Aditya Kumar, Parijat Sarkar, Md. Jafurulla, Shishu Pal Singh, Jana Selent, Amitabha Chattopadhyay
    Academic press:
    Science Advances (rok: 2021, tom: 7, strony: eabh2922), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abh2922 - link to the publication
  11. Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
    Authors:
    Hemlata Dwivedi Agnihori, Madhu Chaturvedi, Mithu Baidya, Tomasz Maciej Stepniewski Shubhi Pandy, Jagannath Maharana, Ashish Srivastava, NAtarin Caengprasath, Aylin C Hanyaloglu, Jana Selent, Arun Shukla
    Academic press:
    Science Advances (rok: 2020, tom: 6, strony: eabb8368), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abb8368 - link to the publication
  12. Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors
    Authors:
    Jagannath Maharana, Fumiya K Sano, Parishmita Sarma, Manish K Yadav, Longhan Duan, Tomasz M Stepniewski, Madhu Chaturvedi, Ashutosh Ranjan, Vinay Singh, Sayantan Saha, Gargi Mahajan, Mohamed Chami, Wataru Shihoya, Jana Selent, Ka Young Chung, Ramanuj Banerjee, Osamu Nureki, Arun K Shukla
    Academic press:
    Science (rok: 2024, tom: 383, strony: 101-108), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/science.adj3347 - link to the publication
  13. Structural dynamics bridge the gap between the genetic and functional levels of GPCRs
    Authors:
    Mariona Torrens-Fontanals, Tomasz M. Stepniewski, David E. Gloriam, Jana Selent
    Academic press:
    Current Opinion in Structural Biology (rok: 2021, tom: 69, strony: 150-159), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.sbi.2021.04.005 - link to the publication
  14. Mechanistic insights into dopaminergic and serotonergic neurotransmission–concerted interactions with helices 5 and 6 drive the functional outcome
    Authors:
    Tomasz Maciej Stepniewski, Arturo Mancini, Richard Ågren, Mariona Torrens-Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selent
    Academic press:
    Chemical science (rok: 2021, tom: 12, strony: 10990-11003), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1SC00749A - link to the publication
  15. Phosphorylation barcodes direct biased chemokine signaling at CXCR3
    Authors:
    Dylan S Eiger, Jeffrey S Smith, Tujin Shi, Tomasz Maciej Stepniewski, Chia-Feng Tsai, Christopher Honeycutt, Noelia Boldizsar, Julia Gardner, Carrie D Nicora, Ahmed M Moghieb, Kouki Kawakami, Issac Choi, Chloe Hicks, Kevin Zheng, Anmol Warman, Priya Alagesan, Nicole M Knape, Ouwen Huang, Justin D Silverman, Richard D Smith, Asuka Inoue, Jana Selent, Jon M Jacobs, Sudarshan Rajagopal
    Academic press:
    Cell Chemical Biology (rok: 2023, tom: 30, strony: 362-382), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chembiol.2023.03.006 - link to the publication
  1. Application of Biomolecular Simulations to G Protein–Coupled Receptors (GPCRs)
    Authors:
    M Torrens-Fontanals, TM Stepniewski, I Rodríguez-Espigares, J Selent
    Book:
    Biomolecular Simulations in Structure‐Based Drug Discovery (rok: 2018, tom: 1, strony: 205-223), Wydawca: Wiley‐VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy