Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

2018/29/B/NZ7/00082

Keywords:

pain opioid peptides pronociceptive neuropeptides opioid receptors and their ligands neuropathic pain model (CCI) opioid-induced hyperalgesia model (OIH) synthesis of new bifunctional hybrids

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Przewłocka 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 961 200 PLN

Project start date (Y-m-d): 2019-01-28

Project end date (Y-m-d): 2025-01-27

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (5)
  1. Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse chronic constriction injury model of neuropathic pain
    Authors:
    Starnowska-Sokół J., Piotrowska A., Bogacka J., Makuch W., Mika J., Witkowska E., Godlewska M., Osiejuk J., Gątarz S., Misicka A., Przewłocka B.
    Academic press:
    Neuropharmacology (rok: 2020, tom: 178, strony: 108232), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2020.108232 - link to the publication
  2. Multifunctional Opioid-Derived Hybrids in Neuropathic Pain: Preclinical Evidence, Ideas and Challenges
    Authors:
    Starnowska-Sokół J., Przewłocka B.
    Academic press:
    Molecules (rok: 2020, tom: 25(23), strony: 5520), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25235520 - link to the publication
  3. Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems
    Authors:
    Wawrzczak-Bargieła A., Ziółkowska B., Piotrowska A., Starnowska-Sokół J., Rojewska E., Mika J., Przewłocka B., Przewłocki R.
    Academic press:
    Neurotoxicity Research (rok: 2020, tom: 37(4), strony: 800-814), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-020-00166-4 - link to the publication
  4. Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores
    Authors:
    Witkowska E., Godlewska M., Osiejuk J., Gątarz S., Wileńska B., Kosińska K., Starnowska-Sokół J., Piotrowska A., Lipiński P., F., Matalińska J., Dyniewicz J., Halik P., K., Gniazdowska E., Przewlocka B., Misicka A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23020674. - link to the publication
  5. Functional characterization of a novel opioid, PZM21, and its influence on behavioural responses to morphine.
    Authors:
    Kudla L., Bugno R., Skupio U., Wiktorowska L., Solecki W., Wojtas A. Golembiowska K., Zádor F., Benyhe S., Buda S., Makuch W., Przewlocka B., Bojarski A., Przewlocki R.
    Academic press:
    British Journal of Pharmacology (rok: 2019, tom: 176, strony: 4434-4445), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/bph.14805 - link to the publication
  6. Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain
    Authors:
    Piotrowska A., Starnowska-Sokół J., Makuch W., Mika J., Witkowska E., Tymecka D., Ignaczak A., Wilenska B., Misicka A., Przewłocka B.
    Academic press:
    PAIN (rok: 2021, tom: 162, strony: 432–445), Wydawca: LWW Journals - Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/j.pain.0000000000002045 - link to the publication
  1. The effects of opioids on immune system – the role of glial cells in the development of opioid tolerance and OIH in the model of neuropathic pain.
    Authors:
    Piotrowska A., Bogacka J., Starnowska-Sokół J., Ciapała K., Przewłocka B.
    Conference:
    12th Congress of the European Pain Federation EFIC (rok: 2022, ), Wydawca: EFIC
    Data:
    konferencja 27.04-01.05.2022
    Status:
    Published
  2. Opioid-induced hyperalgesia (OIH) and neuropathic pain (CCI model) are accompanied by abnormal phosphorylation of mu opioid (MOR) receptors in the mouse spinal cord.
    Authors:
    Piotrowska A., Starnowska-Sokół J., Bogacka J., Ciapała K., Przewłocka B.
    Conference:
    12th Congress of the European Pain Federation EFIC (rok: 2022, ), Wydawca: EFIC
    Data:
    konferencja 27.04-01.05.2022
    Status:
    Published
  3. The analgesic effect of new bifunctional compounds in neuropathic pain.
    Authors:
    Starnowska-Sokół J., Przewlocka B.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 2019-06-22-27
    Status:
    Published
  4. Importance of opioid receptors phosphorylation in nociceptive transmission and morphine analgesic potency in animal model of neuropathic pain: cellular and molecular differences in the mechanism of opioid-induced tolerance and hyperalgesia.
    Authors:
    Piotrowska A., Bogacka J., Ciapała K., Przewłocka B.
    Conference:
    The 3rd International Conference, Controversies in Neuropathic Pain (rok: 2023, ), Wydawca: BioEvents
    Data:
    konferencja 20-21.11.2023
    Status:
    Published
  5. The role of POMC products in the modulation of MOR and MC4 signaling after Chronic Constriction Injury (CCI) of the Sciatic Nerve
    Authors:
    Bogacka J., Piotrowska A., Ciapała K., Przewłocka B.
    Conference:
    The 3rd International Conference, Controversies in Neuropathic Pain (rok: 2023, ), Wydawca: BioEvents
    Data:
    konferencja 20-21.11.2023
    Status:
    Published

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