Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

2011/03/N/ST5/04701

Keywords:

opioid peptides deltorphin I dermorphin alfa-alkyl-beta-azido(amino)alanines

Descriptors:

  • ST5_23:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

POLITECHNIKA ŁÓDZKA, Politechnika Łódzka, Wydział Chemiczny,

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anika Lasota 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 117 780 PLN

Project start date (Y-m-d): 2012-08-27

Project end date (Y-m-d): 2015-02-26

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. pompa próżniowa (6 800 PLN)
  2. komumna semi-preparatywna C18 (4 899 PLN)
  3. łaźnia ultradźwiękowa (3 600 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Synthesis, biological activity and NMR-based structural studies of deltorphin I analogues modified in message domain with a new α,α-disubstituted glycines
    Authors:
    Lasota A., Frączak O., Muchowska A., Nowakowski M., Maciejczyk M., Ejchart A., Olma A.
    Academic press:
    CHEMICAL BIOLOGY & DRUG DESIGN (rok: 2016, tom: brak, strony: brak), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12730 - link to the publication
  2. Analogues of deltorphin I containing conformationally restricted amino acids in position 2: structure and opioid activity
    Authors:
    Anika Lasota, Oliwia Frączak, Anna Leśniak, Adriana Muchowska, Andrzej W. Lipkowski, Michał Nowakowski, Andrzej Ejchart, Aleksandra Olma
    Academic press:
    Journal of Peptide Science (rok: 2015, tom: 21, strony: 120-125), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/psc.2738 - link to the publication
  1. Synthesis and biological activity of dermorphin and deltorphin I analogues modified in message domain with new α,α-disubstituted amino acids
    Authors:
    Anika Lasota, Oliwia Frączak, Aleksandra Olma, Adriana Muchowska, Andrzej Lipkowski
    Conference:
    33rd European Peptide Symposium (rok: 2104, ), Wydawca: Bulgarian Peptide Society
    Data:
    konferencja 31 sierpnia-5 września
    Status:
    Published
    DOI:
    link to the publication
  2. Structure-Activity Relationships of Constrained Dermorphin Analogues Containing an α-Alkyl-β-Substituted Alanines
    Authors:
    Anika Lasota , Oliwia Frączak , Adriana Muchowska , Aleksandra Misicka , Michał Nowakowski , Maciej Maciejczyk , Andrzej Ejchart, Aleksandra Olma
    Conference:
    24th American Peptide Symposium (rok: 2015, ), Wydawca: American Peptide Society
    Data:
    konferencja 20-25 Czerwiec 2015
    Status:
    Published
    DOI:
    link to the publication

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